Colorectal cancer biomarkers and their impact on the clinical practice

James Crespo; Ana Paula Victorino; Kelly Araujo; Luiz Henrique Araujo; Fernando Meton de Alencar Camara Vieira

doi:10.5935/2526-8732.20210025

Brazilian Journal of Oncology, Inhaltsverzeichnis

CC BY 4.0 · Brazilian Journal of Oncology 2021; 17: e-20210025
DOI: 10.5935/2526-8732.20210025

Review Article

Clinical Oncology

Colorectal cancer biomarkers and their impact on the clinical practice

Biomarcadores de câncer colorretal e seu impacto na prática clínica

Autor*innen

James Crespo

¹Americas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - Brazil

²Instituto COI, Medical Oncology - Rio de Janeiro - RJ - Brazil
Ana Paula Victorino

¹Americas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - Brazil

²Instituto COI, Medical Oncology - Rio de Janeiro - RJ - Brazil
Kelly Araujo

¹Americas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - Brazil

²Instituto COI, Medical Oncology - Rio de Janeiro - RJ - Brazil
Luiz Henrique Araujo

¹Americas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - Brazil

²Instituto COI, Medical Oncology - Rio de Janeiro - RJ - Brazil
Fernando Meton de Alencar Camara Vieira

¹Americas Centro de Oncologia Integrado, Medical Oncology - Rio de Janeiro - RJ - Brazil

²Instituto COI, Medical Oncology - Rio de Janeiro - RJ - Brazil

Abstract

Alle Artikel dieser Rubrik

ABSTRACT

Colorectal cancer (CRC) holds third place in the global ranking of malignancies worldwide. Patients with CRC commonly show distinct outcomes and treatment responses due to their biological features and tumoral biomarkers. This review explores the repertoire of molecular biomarkers in CRC, comprised of chromosomal aberrations and genomic instability and genetic mutations. We also underline the stratification of CRC patients into four clinically defined subsets: CMS1 (MSI, immune); CMS2 (canonical); CMS3 (metabolic); and CMS4 (mesenchymal), as well as novel techniques to be applied very soon in the field, such as cell-free DNA, tumor mutational burden, and microbiome profiling.

RESUMO

O câncer colorretal (CCR) ocupa o terceiro lugar no ranking mundial de doenças malignas. Pacientes com CCR geralmente apresentam resultados e respostas ao tratamento distintos devido às suas características biológicas e biomarcadores tumorais. Esta revisão explora o repertório de biomarcadores moleculares no CCR, composto por aberrações cromossômicas e instabilidade genômica e mutações genéticas. Também destacamos a estratificação dos pacientes com CCR em quatro subconjuntos clinicamente definidos: CMS1 (MSI, imune); CMS2 (canônico); CMS3 (metabólico); e CMS4 (mesenquimal), bem como novas técnicas a serem aplicadas muito em breve na área, como DNA livre de células, carga mutacional tumoral e perfil do microbioma.

Keywords:

Biomarcadores - Genômica - Prognóstico - Agentes antineoplásicos - Neoplasias colorretais.

Descritores:

Biomarcadores - Genômica - Prognóstico - Agentes antineoplásicos - Neoplasias colorretais.

Bibliographical Record
James Crespo, Ana Paula Victorino, Kelly Araujo, Luiz Henrique Araujo, Fernando Meton de Alencar Camara Vieira. Colorectal cancer biomarkers and their impact on the clinical practice. Brazilian Journal of Oncology 2021; 17: e-20210025.
DOI: 10.5935/2526-8732.20210025

Volltext

Referenzen

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