Protein carbonyl products, malondialdehyde, glutathione and vitamins C/E of breast cancer patients subjected to chemotherapy

ABSTRACT

Introduction: Various endogenous and exogenous processes contribute to the production of oxidative stress, of which anticancer drugs may be one. This study aimed at evaluating the effect of breast cancer chemotherapy on oxidative stress.

Material and Methods: Oxidative markers and antioxidant defense molecules were monitored in 59 women undergoing a year of treatment for breast cancer.

Results: During the treatment, the levels of vitamin C and glutathione decreased, while both malondialdehyde and protein carbonyl products increased. Vitamin E levels were affected to a smaller extent. The patients were grouped by principal component analysis using their oxidative stress profiles according to the time of the chemotherapy and 95.9% of the total variance was explained by the first three principal components.

Conclusion: The oxidative stress profile of the study population was modified extensively during one year of exposure to antineoplastic drugs.

RESUMO

Introdução: Vários processos endógenos e exógenos contribuem para a produção de estresse oxidativo, dos quais os fármacos antineoplásicos podem ser um deles. Este estudo teve como objetivo avaliar o efeito da quimioterapia do câncer de mama sobre o estresse oxidativo.

Material e Métodos: Marcadores oxidativos e moléculas de defesa antioxidante foram monitorados em 59 mulheres submetidas a um ano de tratamento para câncer de mama.

Resultados: Durante o tratamento, os níveis de vitamina C e glutationa diminuíram, enquanto o malondialdeído e os produtos proteicos carbonílicos aumentaram. Os níveis de vitamina E foram afetados em menor grau. As pacientes foram agrupadas por análise de componentes principais usando seus perfis de estresse oxidativo de acordo com o tempo da quimioterapia e 95,9% da variância total foi explicada pelos três primeiros componentes principais.

Conclusão: O perfil de estresse oxidativo da população estudada foi amplamente modificado, durante um ano de exposição aos antineoplásicos.

Keywords:

Oxidative stress - Biomarkers - Breast diseases

Descritores:

Estresse oxidativo - Biomarcadores - Doenças da mama

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