CC BY-NC 4.0 · Arch Plast Surg 2019; 46(02): 181-184
DOI: 10.5999/aps.2018.01284
Communication

The use of botulinum toxin type A to minimize scarring in cleft lip repair: A literature review

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
,
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
› Author Affiliations

Introduction

Postsurgical scars can be a major concern for many patients. Young and Hutchison [1] found that patients were usually not satisfied with their surgical scars, with 91% stating that they would value any further improvement in their scars. Cleft lip with or without cleft palate is one of the most common congenital anomalies worldwide [2] [3]. Nonsyndromic cleft lip/palate affects approximately 1.5 to 2.5 cases per 1,000 live births, and its epidemiological distribution varies by ethnicity and geographic area [4] [5]. In today’s culture, there is a major emphasis on facial appearances, largely driven by advances in social media. Individuals with deviations from what is considered “a normal look” may be socially stigmatized in their communities. Therefore, the final facial scar appearance remains a significant concern for affected individuals and their families. Herein, we review the process of wound healing and summarize the literature evaluating the effects of botulinum toxin type A (BTA) on scar formation in cleft lip repair.



Publication History

Received: 18 October 2018

Accepted: 12 January 2019

Article published online:
03 April 2022

© 2019. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Young VL, Hutchison J. Insights into patient and clinician concerns about scar appearance: semiquantitative structured surveys. Plast Reconstr Surg 2009; 124: 256-65
  • 2 Allam E, Windsor L, Stone C. Cleft lip and palate: etiology, epidemiology, preventive and intervention strategies. Anat Physiol 2014; 4: 150
  • 3 Janis JE, Good AL, Taylor SJ. Essentials of plastic surgery. Boca Raton: CRC Press; 2014
  • 4 Tolarova M, Al-Kharafi L, Tolar M. et al. Pediatric cleft lip and palate: background, pathophysiology, etiology [Internet]. Emedicine.medscape.com; c2018 [cited 10 Oct 2018]. Available from: https://emedicine.medscape.com/article/995535-overview
  • 5 Panamonta V, Pradubwong S, Panamonta M. et al. Global birth prevalence of orofacial clefts: a systematic review. J Med Assoc Thai 2015; 98 Suppl 7: S11-21
  • 6 Farhadieh RD, Bulstrode NW, Cugno S. Plastic and reconstructive surgery. Hoboken: Wiley-Blackwell; 2015
  • 7 Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res 2010; 89: 219-29
  • 8 Chang CS, Wallace CG, Hsiao YC. et al. Botulinum toxin to improve results in cleft lip repair: a double-blinded, randomized, vehiclecontrolled clinical trial. PLoS One 2014; 9: e115690
  • 9 Neligan P, Gurtner G. Plastic surgery. London: Elsevier Saunders; 2013
  • 10 Fu KJ, Teichgraeber JF, Greives MR. Botulinum toxin use in pediatric plastic surgery. Ann Plast Surg 2016; 77: 577-82
  • 11 Kedlaya D. Botulinum toxin: overview, history, mechanism of action [Internet]. Emedicine.medscape.com; c2018 [cited 10 Oct 2018]. Available from: https://emedicine.medscape.com/article/325451-overview#a3
  • 12 Kwon TG. Botulinum toxin related research in maxillofacial plastic and reconstructive surgery. Maxillofac Plast Reconstr Surg 2016; 38: 34
  • 13 Jablonka EM, Sherris DA, Gassner HG. Botulinum toxin to minimize facial scarring. Facial Plast Surg 2012; 28: 525-35
  • 14 Gassner HG, Sherris DA, Otley CC. Treatment of facial wounds with botulinum toxin A improves cosmetic outcome in primates. Plast Reconstr Surg 2000; 105: 1948-53
  • 15 Gassner HG, Brissett AE, Otley CC. et al. Botulinum toxin to improve facial wound healing: a prospective, blinded, placebo-controlled study. Mayo Clin Proc 2006; 81: 1023-8
  • 16 Ziade M, Domergue S, Batifol D. et al. Use of botulinum toxin type A to improve treatment of facial wounds: a prospective randomised study. J Plast Reconstr Aesthet Surg 2013; 66: 209-14
  • 17 Zelken J, Yang SY, Chang CS. et al. Donor site aesthetic enhancement with preoperative botulinum toxin in forehead flap nasal reconstruction. Ann Plast Surg 2016; 77: 535-8
  • 18 Lee SH, Min HJ, Kim YW. et al. The efficacy and safety of early postoperative botulinum toxin A injection for facial scars. Aesthetic Plast Surg 2018; 42: 530-7
  • 19 Hu L, Zou Y, Chang SJ. et al. Effects of botulinum toxin on improving facial surgical scars: a prospective, split-scar, double-blind, randomized controlled trial. Plast Reconstr Surg 2018; 141: 646-50
  • 20 Tollefson TT, Senders CM, Sykes JM. et al. Botulinum toxin to improve results in cleft lip repair. Arch Facial Plast Surg 2006; 8: 221-2
  • 21 Galarraga IM. Use of botulinum toxin in cheiloplasty: a new method to decrease tension. Can J Plast Surg 2009; 17: e1-2
  • 22 Chang CS, Wallace CG, Hsiao YC. et al. Botulinum toxin to improve results in cleft lip repair. Plast Reconstr Surg 2014; 134: 511-6