Synthesis

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Issue EFirst/null

Issue 24/2019

Valachová, Dominika; Ferko, Branislav; Puchľová, Eva; Caletková, Oľga; Berkeš, Dušan; Kolarovič, Andrej; Jakubec, Pavol: Stereoselective Synthesis of syn-γ-Hydroxynorvaline and Related α-Amino Acids
https://www.thieme-connect.de/media/synthesis/201924/i_f0447_ga_10-1055_s-0039-1690705.gif

Issue 23/2019

Issue 22/2019

Issue 13/2019

Issue 12/2019

Issue 11/2019

Issue 10/2019

Attard, Jonathan W.; Osawa, Kohei; Guan, Yong; Hatt, Jessica; Kondo, Shin-ichi; Mattson, Anita: Silanediol Anion Binding and Enantioselective Catalysis
https://www.thieme-connect.de/media/synthesis/201910/i_z0774_ga_10-1055_s-0037-1612217.gif

Issue 09/2019

Iskryk, Marharyta; Barysevich, Maryia; Ošeka, Maksim; Adamson, Jasper; Kananovich, Dzmitry: Asymmetric Kulinkovich Hydroxycyclopropanation of Alkenes Mediated by Titanium(IV) TADDOLate Complexes
https://www.thieme-connect.de/media/synthesis/201909/i_z0768_ga_10-1055_s-0037-1611709.gif

Issue 08/2019

Issue 07/2019

Issue 06/2019

Caillé, Julien; Pantin, Mathilde; Boeda, Fabien; Pearson-Long, Morwenna S. M.; Bertus, Philippe: Zinc-Mediated Double Addition on Functionalized Nitriles
https://www.thieme-connect.de/media/synthesis/201906/i_z0726_ga_10-1055_s-0037-1611704.gif

Issue 05/2019

Stöckl, Yannick; Frey, Wolfgang; Lang, Johannes; Claasen, Birgit; Baro, Angelika; Laschat, Sabine: Asymmetric Organocatalysis Revisited: Taming Hydrindanes with Jørgensen–Hayashi Catalyst
https://www.thieme-connect.de/media/synthesis/201905/i_z0760_ga_10-1055_s-0037-1610409.gif
Radtke, M. Alex; Dudley, Caroline C.; O’Leary, Jacob M.; Lambert, Tristan H.: A Scalable, One-Pot Synthesis of 1,2,3,4,5-Pentacarbomethoxycyclopentadiene
https://www.thieme-connect.de/media/synthesis/201905/i_z0826_ga_10-1055_s-0037-1611650.gif
Ueda, Mitsuhiro; Maeda, Ayami; Hamaoka, Kanako; Sasano, Mika; Fukuyama, Takahide; Ryu, Ilhyong: Bromine-Radical-Mediated Site-Selective Allylation of C(sp3)–H Bonds
https://www.thieme-connect.de/media/synthesis/201905/i_z0686_ga_10-1055_s-0037-1610413.gif
Schober, Lukas; Ratnam, Shahilan; Yamashita, Yasunobu; Adebar, Niklas; Pieper, Matthias; Berkessel, Albrecht; Hessel, Volker; Gröger, Harald: An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode
https://www.thieme-connect.de/media/synthesis/201905/i_z0741_ga_10-1055_s-0037-1610404.gif
Wiegand, Anja; Wiese, Vera; Glowacki, Britta; Iovkova, Ljuba; Schirrmacher, Ralf; Jurkschat, Klaus; Krause, Norbert: GlucoSiFA and LactoSiFA: New Types of Carbohydrate-Tagged Silicon-Based Fluoride Acceptors for 18F-Positron Emission Tomography (PET)
https://www.thieme-connect.de/media/synthesis/201905/i_z0819_ga_10-1055_s-0037-1611656.gif
McLellan, Ross; Uzelac, Marina; Bole, Leonie J.; Gil-Negrete, Jose María; Armstrong, David R.; Kennedy, Alan R.; Mulvey, Robert E.; Hevia, Eva: Alkali Metal Effects in Trans-Metal-Trapping (TMT): Comparing LiTMP with NaTMP in Cooperative MTMP/Ga(CH2SiMe3)3 Meta­lation Reactions
https://www.thieme-connect.de/media/synthesis/201905/i_z0802_ga_10-1055_s-0037-1611646.gif

Issue 03/2019

Modemann, Daniel J.; Zlatopolskiy, Boris D.; Urusova, Elizaveta A.; Zischler, Johannes; Craig, Austin; Ermert, Johannes; Guliyev, Mehrab; Endepols, Heike; Neumaier, Bernd: 2-[18F]Fluorophenylalanine: Synthesis by Nucleophilic 18F-Fluorination and Preliminary Biological Evaluation
https://www.thieme-connect.de/media/synthesis/201903/i_z0667_ga_10-1055_s-0037-1611370.jpg

Issue 02/2019

Issue 01/2019

Issue 24/2018

Gao, Qiwen; Xu, Lianyan L.; Parise, Vincent P.; Mehta, Yash R.; Aldrich, Leslie N.: Enantioselective Synthesis of 4-Amino-3-hydroxybenzopyran Flavanol Derivatives from Chalcones
https://www.thieme-connect.de/media/synthesis/201824/i_z0677_ga_10-1055_s-0037-161114.gif
Funt, Liya D.; Tomashenko, Olesya A.; Novikov, Mikhail S.; Khlebnikov, Alexander F.: An Azirine Strategy for the Synthesis of Alkyl 4-Amino-5-(trifluoromethyl)-1H-pyrrole-2-carboxylates
https://www.thieme-connect.de/media/synthesis/201824/i_z0644_ga_10-1055_s-0037-1610840.gif

Issue 23/2018

Okamoto, Haruka; Toh, Kohei; Mochizuki, Takuya; Nakatsuji, Hidefumi; Sakakura, Akira; Hatano, Manabu; Ishihara, Kazuaki: Chiral Pyrophosphoric Acid Catalysts for the para-Selective and Enantioselective Aza-Friedel–Crafts Reaction of Phenols
https://www.thieme-connect.de/media/synthesis/201823/i_e0435_ga_10-1055_s-0037-1610250.gif
Sun, Weitao; Trinchera, Piera; Kurdi, Nada; Palomas, David; Crespo-Otero, Rachel; Afshinjavid, Saeed; Javid, Farideh; Jones, Christopher R.: Aryne-Mediated Arylation of Hantzsch Esters: Access to Highly Substituted Aryl-dihydropyridines, Aryl-tetrahydropyridines and Spiro[benzocyclobutene-1,1′-(3′,4′-dihydropyridines)]
https://www.thieme-connect.de/media/synthesis/201823/i_z0578_ga_10-1055_s-0037-1611065.gif

Issue 21/2018

Belkheira, Mokhtaria; El Abed, Douniazad; Pons, Jean-Marc; Bressy, Cyril: Chemoselective Organoclick–Click Sequence
https://www.thieme-connect.de/media/synthesis/201821/i_z0345_ga_10-1055_s-0037-1610192.gif

Issue 20/2018

Issue 19/2018

Camp, Jason E.; Bousfield, Thomas W.; Dunsford, Jay J.; Adams, James; Britton, Joshua; Fay, Michael W.; Angelis-Dimakis, Athanasios: Dehydrative Cross-Coupling of 1-Phenylethanol Catalysed by Palladium Nanoparticles Formed in situ Under Acidic Conditions
https://www.thieme-connect.de/media/synthesis/201819/i_z0442_ga_10-1055_s-0037-1610246.gif
Rode, Katharina; Palomba, Martina; Ortgies, Stefan; Rieger, Rene; Breder, Alexander: Aerobic Allylation of Alcohols with Non-Activated Alkenes Enabled by Light-Driven Selenium-π-Acid Catalysis
https://www.thieme-connect.de/media/synthesis/201819/i_z0389_ga_10-1055_s-0037-1609938.gif

Issue 18/2018

Issue 17/2018

Issue 16/2018

Issue 15/2018

Issue 13/2018

Yamashita, Yu; Hirano, Yoichi; Takada, Akiomi; Takikawa, Hiroshi; Suzuki, Keisuke: Total Synthesis of Bis-anthraquinone Antibiotic BE-43472B
https://www.thieme-connect.de/media/synthesis/201813/i_z0170_ga_10-1055_s-0037-1610136.jpg

Issue 12/2018

Issue 09/2018

Issue 08/2018

Issue 07/2018

Issue 06/2018

Issue 05/2018

Seifried, Marco; Knoll, Christian; Welch, Jan M.; Müller, Danny; Weinberger, Peter: Unsaturated Aryl and Heteroaryl N1-Tetrazoles from 1-Allyl-1H-tetrazole
https://www.thieme-connect.de/media/synthesis/201805/i_z0703_ga_10-1055_s-0036-1591879.gif

Issue 04/2018

Issue 03/2018

Fuchibe, Kohei; Takayama, Ryo; Aono, Tatsuya; Hu, Ji; Hidano, Tomohiro; Sasagawa, Hisashi; Fujiwara, Masaki; Miyazaki, Shinji; Nadano, Ryo; Ichikawa, Junji: Regioselective Syntheses of Fluorinated Cyclopentanone Derivatives: Ring Construction Strategy Using Transition-Metal–Difluorocarbene Complexes and Free Difluorocarbene
https://www.thieme-connect.de/media/synthesis/201803/i_z0663_ga_10-1055_s-0036-1591728.gif
Li, Jun; Xing, Jun; Lücke, Daniel; Lübken, Dennis; Millbrodt, Lucas; Plentz, Ruben R.; Kalesse, Markus: The Structure Elucidation of Haprolid
https://www.thieme-connect.de/media/synthesis/201803/i_z0684_ga_10-1055_s-0036-1591836.gif

Issue 02/2018

Mancuso, Raffaella; Veltri, Lucia; Russo, Patrizio; Grasso, Giuseppe; Cuocci, Corrado; Romeo, Roberto; Gabriele, Bartolo: Palladium-Catalyzed Carbonylative Synthesis of Functionalized Benzimidazopyrimidinones
https://www.thieme-connect.de/media/synthesis/201802/i_z0629_ga_10-1055_s-0036-1591835.gif

Issue 01/2018

Parsons, Philip J.; Allen, Lewis A. T.; Jones, Daniel R.; Padgham, Alex C.; Pryke, James A.; McKenna, Joseph; O’Reilly, Daniel: Approaches to the Synthesis of Highly Substituted Aromatic and Fused Rings: Metal-Catalysed versus Thermal Cyclisation
https://www.thieme-connect.de/media/synthesis/201801/i_z0606_ga_10-1055_s-0036-1590952.gif

Issue 24/2017

Issue 22/2017

Issue 21/2017

Issue 20/2017

Arii, Hidekazu; Nakabayashi, Kenichi; Mochida, Kunio; Kawashima, Takayuki: Synthesis of π-Extended Siloles Using Intramolecular Chain Hydrosilylation
https://www.thieme-connect.de/media/synthesis/201720/i_z0379_ga_10-1055_s-0036-1590911.gif
López-Rodríguez, Alberto; Domínguez, Gema; Pérez-Castells, Javier: Synthesis of Novel Iminosugar Derivatives Based on a 2-Azabi­cyclo[4.1.0]heptane Skeleton
https://www.thieme-connect.de/media/synthesis/201720/i_z0404_ga_10-1055_s-0036-1589109.gif

Issue 19/2017

Issue 18/2017

Issue 17/2017

Issue 16/2017

Issue 14/2017

Issue 13/2017

Issue 12/2017

Heindl, Andreas H.; Schweighauser, Luca; Logemann, Christian; Wegner, Hermann A.: Azobenzene Macrocycles: Synthesis of a Z-Stable Azobenzenophane
https://www.thieme-connect.de/media/synthesis/201712/i_t0143_ga_10-1055_s-0036-1589006.gif
Afanasyev, Oleg I.; Tsygankov, Alexey A.; Usanov, Dmitry L.; Perekalin, Dmitry S.; Samoylova, Alexandra D.; Chusov, Denis: Some Aspects of Reductive Amination in the Presence of Carbon Monoxide: Cyclopropyl Ketones as Bifunctional Electrophiles
https://www.thieme-connect.de/media/synthesis/201712/i_z0108_ga_10-1055_s-0036-1588817.gif

Issue 11/2017

Pelzer, Stefanie; Neumann, Beate; Stammler, Hans-Georg; Ignat’ev, Nikolai; Eujen, Reint; Hoge, Berthold: Synthesis and Characterization of Tetrakis(pentafluoroethyl)germane
https://www.thieme-connect.de/media/synthesis/201711/i_z0087_ga_10-1055_s-0036-1589005.jpg

Issue 10/2017

Issue 09/2017

Issue 07/2017

Issue 06/2017

Issue 05/2017

D’Alonzo, Daniele; De Fenza, Maria; Palumbo, Giovanni; Romanucci, Valeria; Zarrelli, Armando; Di Fabio, Giovanni; Guaragna, Annalisa: Synthesis of β-l-2′-Fluoro-3′-thiacytidine (F-3TC) Stereoisomers: Toward a New Class of Oxathiolanyl Nucleosides?
https://www.thieme-connect.de/media/synthesis/201705/i_z0722_ga_10-1055_s-0036-1588680.gif
Lavendomme, Roy; Malytskyi, Volodymyr; Vandermeersch, Jeremy; Luhmer, Michel; Jabin, Ivan: One-Step Synthesis of a Unique Molecular Platform for the Selective Functionalization of Calix[6]arenes
https://www.thieme-connect.de/media/synthesis/201705/i_z0746_ga_10-1055_s-0036-1588681.gif

Issue 04/2017

Fopp, Carolin; Isaac, Kevin; Romain, Elise; Chemla, Fabrice; Ferreira, Franck; Jackowski, Olivier; Oestreich, Martin; Perez-Luna, Alejandro: Stereodivergent Synthesis of β-Heteroatom-Substituted Vinyl­silanes by Sequential Silylzincation–Copper(I)-Mediated Electrophilic­ Substitution
https://www.thieme-connect.de/media/synthesis/201704/i_z0762_ga_10-1055_s-0036-1588106.gif
Richard, Jimmy; Birepinte, Mélodie; Charbonnier, Jean Baptiste; Liautard, Virginie; Pinet, Sandra; Pucheault, Mathieu: Borinic Acids via Direct Arylation of Amine–Borane Complexes: An Air- and Water-Stable Boron Source
https://www.thieme-connect.de/media/synthesis/201704/i_z0712_ga_10-1055_s-0036-1588345.gif

Issue 03/2017

Pantaine, Loïc; Laverny, Aragorn; Moreau, Xavier; Coeffard, Vincent; Greck, Christine: Stereoselective Multibond-Forming Process towards Functionalized Sulfamide-Containing Polycycles
https://www.thieme-connect.de/media/synthesis/201703/i_z0638_ga_10-1055_s-0036-1588629.gif

Issue 02/2017

Issue 01/2017

Bier, Claus; Binder, Dennis; Drobietz, Dagmar; Loeschcke, Anita; Drepper, Thomas; Jaeger, Karl-Erich; Pietruszka, Jörg: Photocaged Carbohydrates: Versatile Tools for Controlling Gene Expression by Light
https://www.thieme-connect.de/media/synthesis/201701/i_z0515_ga_10-1055_s-0035-1562617.gif

Issue 20/2016

Du, Haiying; Dudognon, Yohan; Sanchez Duque, Maria del Mar; Goudedranche, Sébastien; Bonne, Damien; Rodriguez, Jean; Bugaut, Xavier; Constantieux, Thierry: Organocatalytic Multicomponent Reactions of 1,3-Dicarbonyls for the Synthesis of Enantioenriched Heterocycles
https://www.thieme-connect.de/media/synthesis/201620/i_z0349_ga_10-1055_s-0035-1561490.gif

Issue 18/2016

Chiarini, Marco; Del Vecchio, Luana; Marinelli, Fabio; Rossi, Leucio; Arcadi, Antonio: Synthesis of 3-Substituted 2,1-Benzisoxazoles by the Oxidative Cyclization of 2-Aminoacylbenzenes with Oxone
https://www.thieme-connect.de/media/synthesis/201618/i_e0249_ga_10-1055_s-0035-1561471.gif

Issue 17/2016

Issue 16/2016

Capel, E.; Vidal-Albalat, A.; Rodríguez, S.; González, F. V.: Preparation of Morpholines and Benzoxazines Starting from Nitroepoxides
https://www.thieme-connect.de/media/synthesis/201616/i_z0288_ga_10-1055_s-0035-1561466.gif

Issue 15/2016

Issue 14/2016

Bontemps, Alexis; Mariaule, Gaëlle; Desbène-Finck, Stéphanie; Helissey, Philippe; Giorgi-Renault, Sylviane; Michelet, Véronique; Belmont, Philippe: Silver-Catalyzed Domino Hydroarylation/Cycloisomerization Reactions of 2-Alkynylquinoline-3-carbaldehydes: Access to (Hetero)arylpyranoquinolines
https://www.thieme-connect.de/media/synthesis/201614/i_z0264_ga_10-1055_s-0035-1562234.gif

Issue 13/2016

Issue 12/2016

Machara, Aleš; Endoma-Arias, Mary Ann A.; Císařova, Ivana; Cox, D. Phillip; Hudlický, Tomáš: Synthesis of Nororipavine and Noroxymorphone via N- and O-Demethylation of Iron Tricarbonyl Complex of Thebaine
https://www.thieme-connect.de/media/synthesis/201612/i_z0164_ga_10-1055_s-0035-1561435.gif

Issue 11/2016

Issue 09/2016

Issue 08/2016

Issue 07/2016

Issue 06/2016

Issue 05/2016

Bernardim, Barbara; Couch, Erica D.; Hardman-Baldwin, Andrea M.; Burtoloso, Antonio C. B.; Mattson, Anita E.: Divergent Roles of Urea and Phosphoric Acid Derived Catalysts in Reactions of Diazo Compounds
https://www.thieme-connect.de/media/synthesis/201605/i_e0559_ga_10-1055_s-0035-1561061.gif

Issue 04/2016

Issue 03/2016

Issue 02/2016

Issue 01/2016

Issue 21/2015

Issue 20/2015

Jarzebski, Andreas; Bannwarth, Christoph; Tenten, Christina; Benkhäuser, Christian; Schnakenburg, Gregor; Grimme, Stefan; Lützen, Arne: Synthesis, Chiral Resolution, and Absolute Configuration of Functionalized Tröger’s Base Derivatives: Part III
https://www.thieme-connect.de/media/synthesis/201520/i_t0421_ga_10-1055_s-0035-1560181.gif

Issue 19/2015

Issue 17/2015

Issue 16/2015

Skiredj, Adam; Beniddir, Mehdi A.; Joseph, Delphine; Bernadat, Guillaume; Evanno, Laurent; Poupon, Erwan: Harnessing the Intrinsic Reactivity within the Aplysinopsin Series for the Synthesis of Intricate Dimers: Natural from Start to Finish
https://www.thieme-connect.de/media/synthesis/201516/i_z0242_ga_10-1055_s-0034-1381032.gif

Issue 14/2015

Astruc, Didier; Wang, Dong; Deraedt, Christophe; Liang, Liyuang; Ciganda, Roberto; Ruiz, Jaime: Catalysis Inside Dendrimers
https://www.thieme-connect.de/media/synthesis/201514/i_z0175_ga_10-1055_s-0034-1380868.gif

Issue 11/2015

Teijaro, Christiana N.; Zhao, Senzhi; Kokkonda, Praveen; Andrade, Rodrigo B.: Total Syntheses of (–)-Alstolucines A, B, and F, (–)-Echitamidine, and (–)-N-Demethylalstogucine
https://www.thieme-connect.de/media/synthesis/201511/i_z0086_ga_10-1055_s-0034-1378698.gif

Issue 09/2015

De Coen, Laurens M.; Jatczak, Martyna; Muylaert, Koen; Mangelinckx, Sven; Stevens, Christian V.: Straightforward Synthesis of Functionalized Furo[3,4-d]pyrimidine-2,4-diones
https://www.thieme-connect.de/media/synthesis/201509/i_z0031_ga_10-1055_s-0034-1380321.gif

Issue 08/2015

Issue 07/2015

Issue 02/2015

Barrios, Francis J.; Springer, Brannon C.; Hazlitt, Robert A.; Colby, David A.: Effect of Substituents and Stability of Transient Aluminum–Aminals­ in the Presence of Nucleophiles
https://www.thieme-connect.de/media/synthesis/201502/i_m0630_ga_10-1055_s-0034-1379635.gif