28. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber

Abstracts (HTML) List of Authors

Baba, HA

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen
Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Bahr, MJ

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen
Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH

Bahra, M

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Baier, L

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Balachandran, M

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Balagopal, A

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)

Bantel, H

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen
Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates
Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH

Bara, C

Chronic hepatitis E in heart transplant recipients

Bara, CL

HEV-specific T-cell responses are associated with control of HEV infection

Barbacid, M

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Barikbin, R

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

Baron, U

Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf

Barreiros, AP

Efficacy, safety and diagnostic accuracy of ultrasound guided biopsies of focal liver lesions: a single center experience in 214 patients

Barsotti, A

A nuclear pore component regulates select p53 target genes

Bartens, A

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Bartenschlager, R

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Batke, E

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Batra, A

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

Batusic, DS

Lactoferrin gene expression upregulation in liver during turpentine oil- or bacterial LPS-induced acute phase reaction

Bauer, S

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis
Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Bauer, T

Add-on of pegylated interferon alpha–2a (PEG-IFN) triggers antigen-independent TNF-alpha production by CD4+ T cells in patients with pretreated chronic hepatitis B

Baumgarten, A

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)
Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting
Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert
Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Baus, C

Vitamin D and depression in chronic liver disease

Bechmann, LP

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure
Low sodium urine concentration is associated with poor survival in patients with HRS
Bariatric surgery ameliorates NAFLD in morbidly obese patients

Bechstein, WO

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen
Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie
Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Becker, H

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität
A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Becker, K

The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

Becker, M

Src kinase Fyn mediates hyperosmolarity-induced Mrp2- and Bsep-retrieval from the canalicular membrane in a cortactin dependent way

Becker, T

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Beckmann, J

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Begus-Nahrmann, Y

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Beisel, C

Hepatitis C Therapie in HCV/HIV koinfizierten Patienten – eine monozentrische Kohortenstudie
Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)
Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Bender, M

Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Beneken, C

EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

Bengsch, B

Hierarchy of inhibitory receptor expression by Hepatitis B Virus (HBV)-specific CD8+ T cells in chronic HBV infection

Benten, D

Immortalisierte humane hepatische Sternzellen migrieren schädigungsspezifisch in der Mausleber und führen zu exzessiver Leberfibrose
Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)
Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Benz, K

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Berchtold, S

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics
Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena
Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Berg, T

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection
Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A
Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study
All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study
Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Berger, A

Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Berger, C

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Bergheim, I

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen
Einfluss von akutem Bierkonsum auf die Leber: Untersuchungen im Mausmodell

Bergmann, C

Genetic characteristics of the human hepatic stellate cell line LX–2

Bernhagen, J

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Berr, F

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Berres, ML

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages
Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

Bettinger, D

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis
Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

Beuers, U

Antimitochondriale Antikörper sind ungeeignet zur Diagnose der Primär Biliären Zirrhose in Mäusen

Bexten, T

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen
Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie
Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Bierhaus, A

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Birth, M

Klarzellige Herde veränderter Hepatozyten der menschlichen Leber zeigen eine Überexpression der protoonkogenen Signalwege AKT/mTOR und Ras/Raf1 sowie einen lipogenen Phänotyp (analog dem Hyperinsulinämie-induzierten Hepatokarzinogenese-Modell der Ratte und hepatozellulären Karzinomen beim Menschen)

Bischoff, SC

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen
Einfluss von akutem Bierkonsum auf die Leber: Untersuchungen im Mausmodell

Bissinger, M

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

Bitzer, M

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells
Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus
Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics
Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena
Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase
Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates
Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC
Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Blankenstein, A

Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

Blaschke, M

Persistent HCV-infection and liver damage change vitamin-D-metabolism
IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection
IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

Blüher, M

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Blum, HE

Hierarchy of inhibitory receptor expression by Hepatitis B Virus (HBV)-specific CD8+ T cells in chronic HBV infection
Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis
Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?
Role of the transcription factor c-Jun/AP–1 in response to β-Catenin signaling in the liver

Bock, M

Optimization of maturity levels of human hepatic cell lines in tissue culture

Bode, JG

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes
Distinct functions of the MAPKAP kinases MK2 and MK3 in the regulation of the inflammatory response in macrophages

Boecher, WO

All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Boekschoten, M

Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen
c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell

Boesecke, C

Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert

Boger, R

The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

Bohner, A

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice
Komplexe genetische Determinanten der HCC-Initiation

Bonavita, C

Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie
Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Boogaerts, G

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

Borkham-Kamphorst, E

Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro but fails to attenuate ongoing liver fibrogenesis in vivo

Bösmüller, HC

Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

Bosserhoff, A

Expression of the atypical cadherin Fat1 in hepatic fibrosis
GLUT 1 expression favors formation and growth of hepatic metastasis
BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models
Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis
Increased expression of the glucose transporter GLUT1 in liver fibrosis
Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

Bossow, S

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells
Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus
Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Böttcher, G

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Böttcher, JP

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Böttger, J

A Microfluidic 3D Hepatocyte Culture System -HepaChip®- For Drug And Toxicity Investigations

Braspenning, J

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells
Application of upcyte® technology to primary cells for developing alternatives to current in vitro metabolism models

Braun, F

Patienten mit HCC profitieren von Extended Criteria Donor Organs

Brauner, C

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Braunschweiger, I

Ribavirin beeinflusst unterschiedlich die Funktionen von CD4+ TH1-, TH2- und regulatoischen T-Zell-Klonen bei chronischer Hepatitis C

Breitfeld, P

Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

Breitkopf-Heinlein, K

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Bremer, B

Chronic hepatitis E in heart transplant recipients
HEV-specific T-cell responses are associated with control of HEV infection

Brennan, TV

Functional analysis of immunological mechanisms following mouse liver transplantation

Breuhahn, K

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration
Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma
Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation
Influence of IL–1β and IL–1 receptor antagonist on T-cell adhesion to hepatic endothelial cells: a potential implication for leukocyte recruitment in HCC
A nuclear pore component regulates select p53 target genes
The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Brevick, L

Schlüsselrolle von PGE2 im Circulus vitiosus der Prostaglandin- und Cytokin-vermittelten hepatischen Insulinresistenz

Bröcker-Preuß, M

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Brodzinski, A

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection

Bröring, R

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells
Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro
Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro
In vivo treatment with nanolipid-formulated siRNAs targeting ISG15 leads to enhanced responsiveness to interferon in primary hepatocytes
Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

Brost, S

Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

Brückner, S

Charakterisierung und hepatozytäre Differenzierung von mesenchymalen Stammzellen aus dem Fettgewebe der immundefizienten Maus
MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Brummelkamp, T

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Brunner, C

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Bruns, T

Pyuria in patients with cirrhosis and its impact on survival

Bucala, R

A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase

Bücker, A

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

Buechler, C

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis
Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver

Buggisch, P

Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)
The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)
Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study
Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting
Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Burghardt, S

The role of non-professional liver-resident APCs for inhibition of immune-mediated hepatitis in the mouse liver

Bürk, J

Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

Busch, D

Klonierung AFP-spezifischer HLA.A2 allo-restringierter cytotoxischer T-Zellen aus dem naiven T Zell Repertoire

Busch, DH

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Bussemaker, H

A nuclear pore component regulates select p53 target genes