28. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber

Abstracts (HTML) List of Authors

Lackner, K

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

Lalemann, W

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

Lammert, F

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice
IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice
Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines
Evidence for a heterodimeric structure of megalin in liver macrophages
Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results
Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease
Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases
Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion
Vitamin D and depression in chronic liver disease
Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines
Häufigkeit und Risikofaktoren medikamentös-toxischer Leberschäden: eine umfragebasierte Studie in Apotheken
Impaired FGF–19 release and hepatic FGF–19 resistance in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD)
Einfluss der HFE-Varianten C282Y und H63D auf das genetische Risiko bösartiger Gallenwegserkrankungen: potentielle Modulation durch H63D-Homozygotie
Komplexe genetische Determinanten der HCC-Initiation
ABCB4 deficiency is causative for hepatic copper accumulation in a patient with features of Wilson Disease

Lampe, J

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells
Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus
Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena
Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC
Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Lang, H

IgG4-related sclerosing cholangitis mimicking cholangiocellular carcinoma in a patient with obstructive jaundice

Lang, SA

Resection vs. Transplantation as Curative Treatment Options for Hepatocellular Carcinoma in Cirrhosis – Systematic Review

Lange, N

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

Lange, S

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells
Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

Langhans, B

Ribavirin beeinflusst unterschiedlich die Funktionen von CD4+ TH1-, TH2- und regulatoischen T-Zell-Klonen bei chronischer Hepatitis C
Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Langheinrich, A

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Lankisch, TO

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Latzko, P

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Lau, GK

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Lauer, UM

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells
Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus
Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics
Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena
Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase
Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates
Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC
Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Le, AQ

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Lechel, A

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Leder, A

The significance of appropriate controls in surgical microRNA studies of the liver

Lee, HW

Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

Lee, K

Functional analysis of immunological mechanisms following mouse liver transplantation
Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Lee, S

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

Lehmann, E

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Lehner, F

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Leisner, U

HBsAg-specific humoral and cellular immune responses in children and adolescents 8–14 years after vaccination against hepatitis B

Leithäuser, F

IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

Lembcke, C

Regulation des Schilddrüsenhormonabbaus durch Mausstamm-spezifische Fasten-abhängige UDP-Glucuronosyltransferase-Induktion

Leucht, AK

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Leucht, K

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Leung, NWY

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B

Li, J

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Li, Q

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice
TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells
Dll4 plays a critical role in HBV-associated liver fibrogenesis
Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Liebisch, G

FATP 4 beeinflusst die Palmitat induzierte Apoptose durch Veränderung des Lipidstoffwechsels
Ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) Generates Hepatoprotective conjugated UDCA, Phosphatidylcholine, Medium-chain Fatty acids and Plasmalogen 16: 1

Liebl, J

Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

Liedtke, C

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell
Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen
JNK1 is protective for the progression of NEMO-dependent hepatitis
Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis
Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

Limmer, A

Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation

Lindhorst, A

Persistent HCV-infection and liver damage change vitamin-D-metabolism
IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection

Linhart, M

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose
Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

Lippert, S

The significance of appropriate controls in surgical microRNA studies of the liver

Liu, Y

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice
Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes
TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways
Dll4 plays a critical role in HBV-associated liver fibrogenesis

Lobsien, D

Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron

Lock, JF

Valide nicht-invasive Diagnostik einer Leberzirrhose durch Messung der maximalen Leberfunktionskapazität mittels LiMAx-Test

Lohmann, V

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Lohse, A

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)

Lohse, AW

Atypische Präsentation der Primär biliären Zirrhose bei Männern
TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV
Zweitlinientherapie der Primär Biliären Zirrhose: Klinische Charakteristika und Therapieindikation–eine retrospektive Analyse
Bestimmung des transhepatischen Endotoxin-Gradienten vor und nach Anlage eines transjugulären portosystemischen Shunts (TIPS)
EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC
Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling
Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum
Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection
PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION
Differenzierte Untersuchung direkt karzinogener Effekte von HCV-Proteinen in immortalisierten humanen Hepatozyten
THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS
Patienten mit Primär Sklerosierender Cholangitis weisen ein gestörtes Gleichgewicht zwischen Foxp3+ regulatorischen T-Zellen und proinflammatorischen Th17 Zellen auf
Chronische Hepatitis C Infektion: Herausforderung Alter
IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease
Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes
IFN-gamma und IL–17 Produktion durch SepSecS-reaktive T Zellen aus Patienten mit Autoimmuner Hepatitis
HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Longerich, T

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis
Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma
Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation
In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1
AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma
RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Lorenzo Bermejo, J

Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

Loscher, C

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication

Loss, M

Weniger als 10% der Patienten mit einem Hepatozellulären Karzinom kommen für eine Lebertransplantation in Frage und zeigen die besten (Langzeit-) Überlebensraten

Louis, M

Adaptive CD4+ regulatorische T-Zellen regulieren die Fibrogenese durch Produktion von IL–8 bei chronischer Hepatitis C

Lovas, A

Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury
Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

Lu, M

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Lü, S

Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

Lübberstedt, M

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Luda, C

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

Ludwig, JM

Das Gallensäure-Phospholipid-Konjugat Ursodeoxycholyl-Lysophosphatidylethanolamid (UDCA-LPE) vermindert die LPS-vermittelte Inflammation in der Leber

Luedde, T

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

Lui, FC

Functional analysis of immunological mechanisms following mouse liver transplantation

Lukowski, S

TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

Lunova, M

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

Lünse, S

Genistein shows beneficial effects on hepatic lipid metabolism in an in vitro hepatic steatosis model
Soy isoflavone Genistein affects energy metabolism in a steatotic liver model

Lupke, M

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

Lütgehetmann, M

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV
PRETREATMENT OF HUMANIZED uPA/SCID MICE WITH INTERFERON ALPHA STRONGLY INHIBITS THE ESTABLISHMENT OF HBV INFECTION
THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS
HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

Lüth, A

Regulation des Schilddrüsenhormonabbaus durch Mausstamm-spezifische Fasten-abhängige UDP-Glucuronosyltransferase-Induktion

Lüth, S

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)
Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection
Chronische Hepatitis C Infektion: Herausforderung Alter
IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

Lutterbeck, M

Toll-like receptor-activated primary human hepatocytes produce inflammatory cytokines and different types of interferon, resulting in HCV suppression in vitro

Lutz, T

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)
Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting
Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life