28. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber

Abstracts (HTML) List of Authors

M´Barek, M

THE ENTRY INHIBITOR MYRCLUDEX-B EFFICIENTLY BLOCKS VIRAL SPREADING IN VIVO IN HUMAN LIVER CHIMERIC uPA/ SCID MICE PREVIOUSLY INFECTED WITH HEPATITIS B VIRUS

Ma, H

TREATMENT WITH PEGYLATED INTERFERON-ALPHA INDUCES SUSTAINED SUPPRESSION OF BOTH VIRUS REPLICATION AND ANTIGENEMIA IN HUMANIZED uPA/SCID MICE STABLY INFECTED WITH HBV

Maass, T

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis
Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion

Machann, J

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Mahler, MG

Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases

Mahli, A

Novel in vitro models of alcohol-mediated hepatic injury
In vitro and in vivo models for chemotherapy-associated steatohepatitis reveal an effect of irinotecan on fatty acid binding protein expression

Maier, IB

Fructosereduktion als therapeutischer Ansatz der nicht-alkoholbedingten Fettlebererkrankung (NAFLD) beim Menschen

Mailk, IA

Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

Mainhard, M

p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)

Mais, A

Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

Maldonado, EJ

Die Mini-Laparoskopie ist sicher und zeigt eine hohe Inzidenz akuter Fibrosebildung bei Patienten mit akutem Leberversagen

Malek, N

Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany
Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study

Malek, NP

Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells
Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus
Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics
Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena
Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates
Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC
Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

Malik, I

PECAM–1 (CD31)-gene expression is downregulated by TNF-α or Interferon (IFN-) but upregulated by TGF–1 in peripheral blood leukocytes

Malik, IA

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

Malinowski, M

Valide nicht-invasive Diagnostik einer Leberzirrhose durch Messung der maximalen Leberfunktionskapazität mittels LiMAx-Test

Maltman, D

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Malz, M

The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Manka, P

Serum sodium based modification of the MELD score does not improve the predictive value in acute liver failure

Manns, M

Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load
In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1
Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany
Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Manns, MP

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen
Regulation der Glukuronidierung bei Cholestase (Gallengangsligatur) und durch FXR-Agonisten im humanisierten transgenen UGT1A-Mausmodell
Chronic hepatitis E in heart transplant recipients
Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases
COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS
HEV-specific T-cell responses are associated with control of HEV infection
Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A
Optimization of maturity levels of human hepatic cell lines in tissue culture
Unexpected increase of Hepatitis B Surface Antigen (HBsAg) levels during treatment with nucleos(t)ide analogous 12–24 months before virological breakthrough and resistance
Prospektive Evaluation serologischer Biomarker des Zelltodes zur Differenzierung von einfacher Steatose und NASH
Early versus delayed treatment of acute hepatitis C: Final results of the randomized controlled German HEP-NET acute HCV-III study
Chronic hepatitis E in patients with CVID in Germany?
Geschlechtsspezifische Regulierung des Detoxifikations-Stoffwechsels: der Estrogen Receptor alpha reguliert die transkriptionelle Regulation von UDP-Glukuronosyltransferasen

Mansuroglu, T

Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

Marbach, E

Hedgehog around the clock

Marhenke, S

RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

Marin, JJG

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Markova, A

HEV-specific T-cell responses are associated with control of HEV infection

Marquardt, J

The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

Marquardt, JU

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis
Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion
Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications
Identification of liver specific genes using next generation sequencing technology

Marquitan, G

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Marschall, HU

Impaired FGF–19 release and hepatic FGF–19 resistance in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD)

Martínez Sánchez, JJ

Entrapment of primary human hepatocytes in extracellular matrix gels for long term toxicity studies

Mathé, Z

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Mattu, S

Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc
HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei
Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Matzat, V

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)
Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection
Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Matz-Soja, M

The role of Suppressor of Fused in the regulation of Hedgehog and Wnt/ß-Catenin signaling pathway in adult liver
Veränderte Fettverteilung und Infertilität bei weiblichen, hepatozyten-spezifischen Smo-KO Mäusen: Folge einer inversen Regulation von Cyp17a1 und 3ßHSD mit Bildung von Dihydroepiandrosteron
Hedgehog around the clock
Charakterisierung der Smo-KO-induzierten Steatose in der Leber mittels Shotgun-Lipidomanalyse

Mauss, S

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)
Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting
Der CYP27B1–1260 Promoter Polymorphismus rs120877012 ist bei HCV/HIV koinfizierten Patienten signifikant mit einem Ansprechen auf die Therapie der Hepatitis C Erkrankung (SVR) assoziiert
Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Mayer, N

Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

Mehrabi, A

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Meindl-Beinker, NM

Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation
Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines
Impact of HBV infection on TGF-β signaling in primary human hepatocytes
HCV core protein interferes with Smad1 and Smad3 dependent TGF-β signaling in HCC cells

Meiners, J

Differenzierte Untersuchung direkt karzinogener Effekte von HCV-Proteinen in immortalisierten humanen Hepatozyten

Meinhard, M

Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

Melter, M

Gallensäuren induzieren die Expression von ALR, einem Leberregeneration assoziierten Faktor

Menendez Menendez, K

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten

Mertens, PR

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

Metzger, C

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance to systemic circulating carcinoembryonic antigen: A new mechanism of Tumour-immune-Suppression

Metzger, J

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Meurer, SK

More than a serum parameter: Functional relevance of soluble endoglin (solEng)

Meyer, BG

Chronic hepatitis E in patients with CVID in Germany?

Meyer, C

Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes
TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways
Dll4 plays a critical role in HBV-associated liver fibrogenesis

Meyer, T

Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Meyer-Heithuis, C

COMPREHENSIVE IMMUNOPHENOTYPING OF TREGS AND SERUM CYTOKINES MAY HELP TO DISTINGUISH HCV HEPATITIS FROM REJECTION IN LIVER TRANSPLANT PATIENTS

Mihm, S

Persistent HCV-infection and liver damage change vitamin-D-metabolism
IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection
IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients

Millonig, G

Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo
Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)
Liver stiffness in cardiac insufficiency: Is elevated GGT due to cardiac cirrhosis?
Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Mischak, H

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

Mollenkopf, HJ

Hepatitis B virus surface proteins induce interferon response in the liver of HBV-transgenic mouse

Möller, B

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)
Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Mönch, C

Leberteilresektionen bei kolorektalen Lebermetastasen–Kein Unterschied im Überleben zwischen R0- und R1-Resektionen
Der Possum Score als prädiktiver Marker für Morbidität und Mortalität in der hepatobiliären Chirurgie
Morbidität und die stationäre Behandlungsdauer bei der elektiven Leberteilresektion: Verbesserungspotentiale durch Fast Track Komponenten?

Monin, MB

Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

Montalbano, R

Induction of endoplasmic reticulum-mediated stress pathways in liver cancer cell lines after overexpression of Hepatitis B virus envelope proteins
Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

Monte, MJ

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice

Moog, G

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)
Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting
Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Moradpour, D

Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Moreno Zaldivar, M

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

Morgül, H

The significance of appropriate controls in surgical microRNA studies of the liver

Moriconi, F

Persistent HCV-infection and liver damage change vitamin-D-metabolism
IL28B allelic variation but not polymorphism of CYP27B1 or genotype of HCV is associated with spontaneous elimination of HCV-infection
IL28B genetic variation and ratio of y-GT/ALT as predictors for virological response in chronic hepatitis C virus genotype 1 infected patients
PECAM–1 (CD31)-gene expression is downregulated by TNF-α or Interferon (IFN-) but upregulated by TGF–1 in peripheral blood leukocytes

Mössner, J

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)
Evaluation of a rapid on-site anti-HCV test as screening tool for hepatitis C infection

Mueller, S

Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo
Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)
Liver stiffness in cardiac insufficiency: Is elevated GGT due to cardiac cirrhosis?
Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Müllenbach, R

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice
Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines
Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

Müller, A

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results
Dll4 plays a critical role in HBV-associated liver fibrogenesis

Müller, K

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

Müller, M

p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)
Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury
Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen
c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell
Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma
ROLE OF TUMOR SUPPRESSORS P53 AND P73 IN THE CELLULAR DEFENCE AGAINST HEPATITIS C VIRUS
Hepatitis B Virus Infection triggers AP–1 dependent CD95Ligand expression in HepG2 cells

Müller, T

Variants in the human PPIA gene render host cells refractory to hepatitis C virus infection by destabilization of the essential host factor cyclophilin A

Müller-Vieira, U

Comparison of two size variants of a miniaturized multi-compartment three-dimensional (3D)-bioreactor system for primary human hepatocyte cultivation

Müllhaupt, B

Intestinal inflammation induces alterations in enterohepatic Fgf15 signalling, changes in hepatic bile acid metabolism and a “toxic bile” composition in DSS-treated mice
Impact of genetic concentrative nucleoside transporter variants on interferon/ribavirin therapy response in hepatitis C patients
Age above 60 years is not a negative predictive factor for combined antiviral therapy with pegylated interferon alpha and ribavirin in hepatitis C patients

Mummelthei, A

Concomitant immunological diseases in primary sclerosing cholangitis are a risk factor for reduced survival

Munker, S

TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

Muralev, E

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Mysickova, A

HBV messenger RNA (mRNA) is a strong predictive marker for HBeAg and HBsAg loss during antiviral treatment with nucleoside/nucleotide analogues (NUCs) in patients with chronic hepatitis B virus (HBV) infection