28. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber

Abstracts (HTML) List of Authors

Tacke, F

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages
Der lösliche Urokinase-Plasminogen-Aktivator Rezeptor (suPAR) als neuer diagnostischer und prognostischer Biomarker in der chronischen Lebererkrankung
Evidence for a heterodimeric structure of megalin in liver macrophages
The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis
Prospektive diagnostische und prognostische Evaluation der transienten Leberelastographie bei kritisch kranken Patienten auf einer internistischen Intensivstation

Talas, G

Characterization of liver specific functions of upcyte® hepatocytes grown in 3D and co-cultured with upcyte® endothelial cells

Tautenhahn, M

MSCs augment liver regeneration after paracetamol-induced acute liver injury by their anti-apoptotic and pro-proliferative mode of action

Taylor, J

HDV LACKING HBV CAN INFECT HUMAN HEPATOCYTES IN THE LIVER OF CHIMERIC uPA/SCID MICE AND PERSIST FOR AT LEAST SIX WEEKS BEFORE BEING RESCUED BY SUPERINFECTION WITH HBV

ten Dijke, P

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

Tennert, C

Assoziation genetischer Varianten des CYP2C9 Gens mit einer Hepatotoxizität durch den Endothelinantagonisten Bosentan bei Patienten mit pulmonalarterieller Hypertonie (PAH)

Teuber, G

The Role of Weight Loss (WL) as On-Tretament Predictive Factor for SVR in the Treatment of Chronic Hepatitis C (CHC) Patients with Peginterferon alfa–2A (PEG) and Ribavirin (RBV)
Comparison of therapy outcome of patients with drug addiction (DA) versus patients with former iv drug use (IVDU) treated with Peginterferon alfa–2a/Ribavirin in real life setting
Confirmation of high SVR rates after shortening duration of treatment with Peginterferon alfa–2a (PEG) and Ribavirin (RBV) in Chronic Hepatitis C (CHC) Patients with RVR in Real Life

Teufel, A

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis
Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion
Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications
Identification of liver specific genes using next generation sequencing technology

Teufel, U

Detection of highly carcinogenic, exocyclic etheno-DNA-adducts in the liver of children with non-alcoholic fatty liver disease

Thasler, WE

Novel in vitro models of alcohol-mediated hepatic injury
Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model
Hop bitter acids inhibit PD-L1 expression and tumorigenicity of hepatocellular carcinoma cells
In vitro and in vivo models for chemotherapy-associated steatohepatitis reveal an effect of irinotecan on fatty acid binding protein expression

Thelen, A

Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

Thiel, S

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Thiele, A

Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

Thimme, R

Hierarchy of inhibitory receptor expression by Hepatitis B Virus (HBV)-specific CD8+ T cells in chronic HBV infection
Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis
Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?
Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance
HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection

Thomaschewski, M

Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

Thomssen, A

Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection

Thonig, A

Untersuchungen zur dreidimensionalen Kultivierung primärer Rattenhepatozyten auf kollagenierten Silikonscaffolds

Thorgeirsson, SS

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis
Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

Tiegs, G

Nitric oxide supports carbon monoxide-induced protection from apoptosis in isolated primary mouse hepatocytes
Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes
Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis
Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression
Partial loss of immunological tolerance in CCR5-deficient mice in the murine model of concanavalin A-induced liver injury
Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication
Re-programming of Kupffer Cells for immune regulation in response to ConA-induced liver injury
The role of non-professional liver-resident APCs for inhibition of immune-mediated hepatitis in the mouse liver
The role of the IL–17 axis in a mouse model of drug-induced liver injury

Timm, J

Presence of primary human hepatocytes inhibits expansion of virus-specific CD8+ T cells in vitro
The proapoptotic protein Bim is not differentially regulated in CD8+ T cells from resolved or chronic HCV infection

Timmer, J

Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes

Timo, W

Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus
Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

Tóth, I

Charakterisierung von B – Zell – Aktivierungs- und Koinhibitionsmarkern in Patienten mit chronischen Virusinfektionen (HBV; HCV)
Downregulation of CD73 surface expression in regulatory as well as effector T cells in chronic HCV infection
Fine Characterization and Determination of Cross-Reactivity of HCV-specific CD4+ T Cell Epitopes

Trautwein, C

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages
Der lösliche Urokinase-Plasminogen-Aktivator Rezeptor (suPAR) als neuer diagnostischer und prognostischer Biomarker in der chronischen Lebererkrankung
Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo
The CXCR3 ligand CXCL9 attenuates neoangiogenesis and liver fibrosis in vivo
G-Protein-Rezeptor abhängige Immunmodulation durch Induktion der KC Expression (murines CXCL8/IL–8 Homolog) in murinen hepatischen Sternzellen nach Stimulation mit CXCL9
The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis
Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell
Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen
Prospektive diagnostische und prognostische Evaluation der transienten Leberelastographie bei kritisch kranken Patienten auf einer internistischen Intensivstation
JNK1 is protective for the progression of NEMO-dependent hepatitis
c-met vermeidet die Entwicklung Nicht- Alkoholischer- Fettleberhepatitis (NASH) im Mausmodell
Die anti-oxidative Stressantwort schützt via Keap1/NRF2 in Hepatozyten vor chronischer Leberschädigung
Modulation of hepatic lipid content by Caspase 8 in non-alcoholic steatohepatitis
A functional role of Macrophage Migration Inhibitory Factor (MIF) for liver steatosis in mice by activation of AMP kinase
Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice
All-trans retinoic acid co-administered with pegylated interferon and ribavirin does not influence viral kinetics in hepatitis C infected patients with previous non-response: Results of the ATRACTION study

Trebicka, J

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose
Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension
Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose
HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen
Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose
Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

Treckmann, J

Characteristics of human non-cirrhotic and cirrhotic liver sections in a novel ex vivo perfusion system

Tribica, J

Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence

Triebel, J

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response

Trierweiler, C

Role of the transcription factor c-Jun/AP–1 in response to β-Catenin signaling in the liver

Trippler, M

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

Trylesinski, A

Direkter Vergleich der Hepatitis B Viruskinetik während 12 Wochen mit Telbivudine (LDT) vs. Tenofovir (TDF) vs. Kombination LDT und TDF bei Patienten mit chronischer Hepatitis B
Telbivudine treatment improves renal function of Chronic Hepatitis B (CHB) patients

Tschaharganeh, DF

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell
The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

Tschuschner, A

TIMP–2, Serum-Marker einer portalen Hypertension bei Mukoviszidosepatienten
Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

Tuncay, S

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration