31. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber

Abbas, AS

NAFLD linked hepatic iron stores and impact of fat reducing agents on males and females Rattus norveicus

Gender linked counter effect of N. sativa seeds and P. ovata husks on fibrosis in NAFLD

Abbasi, MH

Damage and recovery of hepatic tissue of Mus musculus inhabited at metallurgical workshop

Abdullah, Z

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Acalovschi, M

Progranulin autoantibodies and genetic variation in patients with cholangiocarcinoma

Ahmad, S

HMGB1 inflammosome activity modulates HIF-1α in a rat model of thioacetamide (TAA)-induced chronic liver damage and cholangiocarcinoma development

Akhar, T

Hepatoprotective Role of Nerium Oleander in Thioacetamide-Induced Chronic Inflammation

Albrecht, U

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Aleithe, S

Cooperation of Hedgehog and Wnt/β-Catenin signalling in regulation of steroidogenesis in the liver

Al-Herwi, E

A common polymorphism of tumor necrosis factor receptor-associated factor 6 (TRAF6) is associated with an increased risk for spontaneous bacterial peritonitis

Alidousty, C

Y-box-binding protein (YB-1) in murine models of hepatic and renal fibrosis

Allweiss, L

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Al Masaoudi, M

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Alsamman, M

Specific Endoglin deletion in primary mouse hepatic stellate cells shows a modulation of TGF-b signaling pathways, aggravating liver fibrosis

Al-Samman, M

Endoglin Knockdown inhibits Proliferation and NO Production in murine Sinusoidal Endothelial Cells in vitro

Alt, Y

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Altevogt, P

Identification and proteomic profiling of biliary exosomes

Altomonte, J

Development of delivery, targeting, and imaging strategies to improve oncolytic vesicular stomatitis virus therapy for hepatocellular carcinoma

Altrock, E

Loss of Integrin-β1 in Hepatocytes Induces Liver Fibrosis

Inflammatory cell infiltration in experimental liver fibrosis is affected by inhibition of fibronectin matrix assembly

Amann, T

Fibroblast growth factor 7 inhibits hepatic steatosis, inflammation and fibrosis in murine models of on non-alcoholic steatohepatitis

Amer, W

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Promoter regulation of the miR-29a/b1 gene by transforming growth factor-β in hepatic stellate cells and in hepatoma cells

Anadol, E

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Anastasiou, O

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Andersen, JB

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Andrassy, J

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Andruszkow, JHK

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Angel, P

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Angele, M

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Arnold, K

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Arslanow, A

Prevalence of hepatic steatosis in healthy health care workers as quantified by controlled attenuation parameter (CAP)

Asimakopoulou, A

Lipocalin 2 (LCN2) in hepatic inflammation

Augustin, HG

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Baba, HA

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

Bachmann, A

Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma

Baer, C

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Bangen, JM

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Bantel, H

Increased serum levels of regenerative miRNAs in patients with spontaneous recovery from acute liver failure

Barbacid, M

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Barikbin, R

An additional heme oxygenase-1 knockout increases maturation of dendritic cells and liver inflammation in mdr2 knockout mice

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Bärmann, J

Identification of CD8+ T-cell epitopes specific for hepatitis C virus genotype 4

Bartenschlager, R

Influence of HCV on CREB gene expression and functional relevance

Hepatitis C Virus activates auto- and paracrine circuits to modify surface expression of growth factor receptors of the Erb family

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

The interaction of the Hepatitis C Virus with intra-cellular signaling converts EGF into a potent inducer of the production of CXCR2-ligands by the infected host cell

Barthenschlager, R

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Batool, S

NAFLD linked hepatic iron stores and impact of fat reducing agents on males and females Rattus norveicus

Bauer, T

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Bäuerlein, FJB

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Baus, C

Improvement of Depressive Symptoms upon Correction of Vitamin D Deficiency in Women with Chronic Liver Disease

Bechmann, LP

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Metformin Treatment Ameliorates Liver Injury Indicating Fatty Liver Polycystic Ovary Syndrome

Visceral Adipose Tissue in NAFLD and NASH Patients is Closely Associated with Liver Injury

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Beck, J

Rolle des Mas Rezeptors in der Leberfibrose

Beck, M

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Becker, T

Representation of human non-alcoholic fatty liver disease in murine models

Beer, A

Histopathology of chronic Hepatitis E

Begher-Tibbe, B

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

Behrendt, P

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Histopathology of chronic Hepatitis E

Beisel, C

Bacterial infection is a common complication in patients with severe alcoholic hepatitis

Beissbarth, T

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

Benson, S

Metformin Treatment Ameliorates Liver Injury Indicating Fatty Liver Polycystic Ovary Syndrome

Benten, D

Bacterial infection is a common complication in patients with severe alcoholic hepatitis

Berg, T

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Bergheim, I

Einfluss von Arginin auf die Entstehung einer Western Style Diät-induzierten nicht alkoholbedingten Fettlebererkrankung (NAFLD): Untersuchungen im Mausmodell

Berkowski, C

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

Berndt, N

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Bernhagen, J

MIF shows profibrotic properties after MCD diet via NKT cell population

Berres, ML

MIF shows profibrotic properties after MCD diet via NKT cell population

Best, J

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Bester, R

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Beyer, M

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Bhadra, OD

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Bias, K

Einfluss von akuten Komplikationen der Leberzirrhose auf die Lebensqualität von Patienten mit Leberzirrhose im Verlauf

Bielow, C

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Bilzer, M

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Birkenfeld, AL

Xenobiotic-dependent induction of the tricarboxylate carrier Slc13a5 in primary cultures of rat hepatocytes

The vicious circle of prostaglandin- and cytokine-dependent hepatic insulin resistance: a key role of prostaglandin E2

Bissinger, M

A20(TNFAIP3) as modulator of TNFα-induced responses in mouse hepatoma cell lines and primary mouse hepatocytes

Blessin, U

Bacterial infection is a common complication in patients with severe alcoholic hepatitis

Boaru, SG

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

NLRP3 inflammasome expression in cultured hepatocytes is regulated by nuclear factor-κB (NF-κB)

Bock, M

Human adult liver stem cells generated from patient samples

Bockmann, JH

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Type III interferons induce cccDNA degradation similar to type I interferons in HBV-infected HepaRG cells

Bocuk, D

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

Bode, J

Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5

Bode, JG

Influence of HCV on CREB gene expression and functional relevance

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Hepatitis C Virus activates auto- and paracrine circuits to modify surface expression of growth factor receptors of the Erb family

Inhibition of the transcriptional regulation of CDCA-induced BSEP expression by IL-1β involves the IL-1β triggered activation of autocrine chemokine circuits

The interaction of the Hepatitis C Virus with intra-cellular signaling converts EGF into a potent inducer of the production of CXCR2-ligands by the infected host cell

Hepatocytes secret a mediator pattern that induces macrophage phenotype with properties of wound healing type and regulatory macrophages

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Bode, KA

Identification and proteomic profiling of biliary exosomes

Boesecke, C

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Böhm, M

Riboflavin Kinase Inhibitor 1 (RKIP1): A Potential Modifier of Fibrogenesis in Liver and Heart

Böhmer, F

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Böhmer, O

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Bohne, F

Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Boor, P

Comparative analysis of C5aR and C5L2 receptor deficiency in liver and kidney fibrosis

Borkham-Kamphorst, E

NLRP3 inflammasome expression in cultured hepatocytes is regulated by nuclear factor-κB (NF-κB)

Platelet-derived growth factor-D intensifies fibrogenesis through upregulation of TIMP-1 expression and signalling through both platelet-derived growth factor receptors type α and β

Lipocalin 2 (LCN2) in hepatic inflammation

Bosserhoff, A

Fibroblast growth factor 7 inhibits hepatic steatosis, inflammation and fibrosis in murine models of on non-alcoholic steatohepatitis

Functional effects of monocarboxylate transporter 1 expression in activated hepatic stellate cells

Increased expression of the Glucose-transporter GLUT1 during hepatic stellate cell activation promotes hepatic fibrosis

Böttger, J

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Cooperation of Hedgehog and Wnt/β-Catenin signalling in regulation of steroidogenesis in the liver

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Regulation of energy metabolism in hepatocytes with induced steatosis

Bowe, A

Activation of PP2A as possible mechanism in HCC therapy

Cholestasis and bile acids induce expression of the oncofetal marker Nope in adult murine hepatocytes independent of Fxr

Boxtermann, M

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Bracht, T

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Brägelmann, C

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Braspenning, J

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Braun, S

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

Breitkopf-Heinlein, K

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Bremer, B

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Serum biomarker profile can predict the outcome of acute HCV infection

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Biomarkers to predict the clinical outcome of hepatitis delta

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Breuhahn, K

A20(TNFAIP3) as modulator of TNFα-induced responses in mouse hepatoma cell lines and primary mouse hepatocytes

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Breunig, I

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Brigitte, B

Array-based gene expression analysis of M1/M2-polarized macrophages during treatment with multi-kinase inhibitor Sorafenib

Broering, R

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Brosch, M

Representation of human non-alcoholic fatty liver disease in murine models

Brossart, P

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Brossert, P

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Brückner, S

Representation of human non-alcoholic fatty liver disease in murine models

Brueckner, S

Regulation der Expression von MMPs und TIMPs nach Transplantation von mesenchymalen Stammzellen im Rattenmodell der chronisch-toxischen Leberschädigung

Brune, M

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Brunner, C

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Brunner, SM

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Bruns, OT

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Bruns, T

A common polymorphism of tumor necrosis factor receptor-associated factor 6 (TRAF6) is associated with an increased risk for spontaneous bacterial peritonitis

Brunskole Hummel, I

HBsAg-specific humoral and cellular immune memory after hepatitis B booster vaccination in adolescents 10 – 15 years after immunization in infancy

Bruss, V

Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Budeus, B

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Buggisch, P

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Burgermeister, E

The extracellular proteinase Expi/Wfdc18 in liver damage and tumour development: A new connection between inflammation, fibrogenesis and malignant growth

Büttner, R

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Promoter regulation of the miR-29a/b1 gene by transforming growth factor-β in hepatic stellate cells and in hepatoma cells

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Caliskan, S

Cytotoxicity of anisidine in hepatic cell lines

Calvisi, DF

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Camargo, RG

The vicious circle of prostaglandin- and cytokine-dependent hepatic insulin resistance: a key role of prostaglandin E2

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Canbay, A

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Metformin Treatment Ameliorates Liver Injury Indicating Fatty Liver Polycystic Ovary Syndrome

Visceral Adipose Tissue in NAFLD and NASH Patients is Closely Associated with Liver Injury

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Eine Sequenzvariation in der Bindungsstelle des Transkriptionsfaktors GATA ist verantwortlich für eine verminderte TRAIL Regulation beim humanen HCC

Carambia, A

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Treg impairment is not a sufficient cause of autoimmune liver inflammation

Castoldi, M

Zerebrale miRNA-Expressionsänderungen bei hepatischer Enzephalopathie

Castven, D

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Cederbaum, AI

Identification of cytochrome CYP2E1 as critical mediator of alcohol effects on steatotic hepatocytes

Chamulitrat, W

Deficiency of calcium-independent phospholipase A2 beta in vivo causes systematic inflammation and hepatocellular carcinoma

Lysophosphatidylcholine (LPC) as central player for hepatic fat accumulation and inflammation: implication for the pathogenesis of NASH

UDCA-LPE modulates different signaling pathways involved in hepatic fibrogenesis

Chavakis, T

Representation of human non-alcoholic fatty liver disease in murine models

Chen, X

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Cheng, X

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Chinatalpati, C

Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5

Christ, B

Regulation der Expression von MMPs und TIMPs nach Transplantation von mesenchymalen Stammzellen im Rattenmodell der chronisch-toxischen Leberschädigung

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Christmann, A

Next generation sequencing analysis of cholestatic patients reveals high impact variation in common and rare candidate genes: Deconstructing the genetic architecture of cholestasis

Christoph, HzS

Eligibility and safety of sofosbuvir in a real-world single center cohort of patients with advanced cirrhosis, including decompensated cirrhosis

Chung, RT

Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype

Churin, Y

Protektiver HBsAg-Expressionsverlust bei HBV-transgenen Mäusen durch Methylierungen der DNA

Verstärkte hepatische Expression neuer MicroRNA bei ABCB4-/- Mäusen im Langzeitmodell

Quantitative Analyse der Tumor-Vaskularisation mittels Mikro-CT in ApoE/LDLR Doppel-Knockout Mäusen unter Western-Diät

Ciesek, S

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Cigliano, A

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Coleman, D

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Cooke, A

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Cornberg, M

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Serum biomarker profile can predict the outcome of acute HCV infection

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Biomarkers to predict the clinical outcome of hepatitis delta

Clinical significance of drug-drug interactions during HCV therapy with sofosbuvir and simeprevir in comparison to first wave protease inhibitors

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Eligibility and safety of sofosbuvir in a real-world single center cohort of patients with advanced cirrhosis, including decompensated cirrhosis

Cox, A

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Cramer, T

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Cubero, FJ

Pharmakologische oder genetische Intervention des CCL5/RANTES Signalweges im in vivo Modell einer chronischer Leberentzündung vermindert die Fibrogenese und Progression zum Hepatozellulären Karzinom

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Curth, HM

Activation of PP2A as possible mechanism in HCC therapy

Czech, B

Fibroblast growth factor 7 inhibits hepatic steatosis, inflammation and fibrosis in murine models of on non-alcoholic steatohepatitis

Functional effects of monocarboxylate transporter 1 expression in activated hepatic stellate cells

Increased expression of the Glucose-transporter GLUT1 during hepatic stellate cell activation promotes hepatic fibrosis

Dahmen, U

Reconstruction and quantification of periportal bile ducts and Hering canal after bile duct ligation

Dammermann, W

Infizierbarkeit der Hepatom-Zelllinie HepaRG durch HBV+ Seren mit niedrigem bis hohem Virustiter

Dandri, M

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Daniel, G

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Darstein, F

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Dayoub, R

Reduced HNF3b (FOXA2) levels in steatosis leads to diminished expression of anti-lipoapoptotic protein ALR

Hepatic detoxification and anti-oxidative response in liver tissue with cholestasis: analysis of Nrf2 dependent gene expression

De Bandt, JP

Einfluss von Arginin auf die Entstehung einer Western Style Diät-induzierten nicht alkoholbedingten Fettlebererkrankung (NAFLD): Untersuchungen im Mausmodell

de Bruin, A

Pharmakologische oder genetische Intervention des CCL5/RANTES Signalweges im in vivo Modell einer chronischer Leberentzündung vermindert die Fibrogenese und Progression zum Hepatozellulären Karzinom

Deest, M

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Degen, C

Einfluss von Arginin auf die Entstehung einer Western Style Diät-induzierten nicht alkoholbedingten Fettlebererkrankung (NAFLD): Untersuchungen im Mausmodell

Delogu, S

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Dembek, C

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Demmel, M

The effect of extended transportation time on the quality of freshly isolated human liver cells

Denk, G

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

De Ponti, AM

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Deterding, K

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Serum biomarker profile can predict the outcome of acute HCV infection

Clinical significance of drug-drug interactions during HCV therapy with sofosbuvir and simeprevir in comparison to first wave protease inhibitors

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Eligibility and safety of sofosbuvir in a real-world single center cohort of patients with advanced cirrhosis, including decompensated cirrhosis

Dewidar, B

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Diehl, L

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Dienes, HP

Histopathology of chronic Hepatitis E

Phenprocoumon-induced liver injury

Promoter regulation of the miR-29a/b1 gene by transforming growth factor-β in hepatic stellate cells and in hepatoma cells

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Dierks, P

Increased expression of CD39 on natural killer cells in patients with chronic hepatitis C is associated with an immature phenotype

Dietz, J

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

Dinh, NV

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Dirsch, O

Reconstruction and quantification of periportal bile ducts and Hering canal after bile duct ligation

Ditze, M

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Dollinger, M

Aldosterone stimulates the non-genomic signaling pathway of the mineralocorticoid receptor in hepatic stellate cells

Dombrowski, F

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Dooley, S

Smad7 suppresses HCC development in a DEN induced mouse model

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Increased serum levels of regenerative miRNAs in patients with spontaneous recovery from acute liver failure

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

The extracellular proteinase Expi/Wfdc18 in liver damage and tumour development: A new connection between inflammation, fibrogenesis and malignant growth

Targeting TGF-β2 in chronic liver diseases

Inflammatory cell infiltration in experimental liver fibrosis is affected by inhibition of fibronectin matrix assembly

Draenert, R

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Drasdo, D

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

Drebber, U

Histopathology of chronic Hepatitis E

Phenprocoumon-induced liver injury

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Dreher, B

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Drescher, H

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Dries, V

Phenprocoumon-induced liver injury

Driftmann, S

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Dropmann, A

Targeting TGF-β2 in chronic liver diseases

Dürl, S

Lineage fate of ductular reactions in liver injury and carcinogenesis

Dzieran, J

Smad7 suppresses HCC development in a DEN induced mouse model

Eberhard, JM

Increased expression of CD39 on natural killer cells in patients with chronic hepatitis C is associated with an immature phenotype

Ebert, M

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

The extracellular proteinase Expi/Wfdc18 in liver damage and tumour development: A new connection between inflammation, fibrogenesis and malignant growth

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Ebert, O

Development of delivery, targeting, and imaging strategies to improve oncolytic vesicular stomatitis virus therapy for hepatocellular carcinoma

Ecker, EM

Everolimus beeinflusst die HCV-Replikationsaktivität

Ederer, M

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Ehlken, H

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Ehlting, C

Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Ehmer, U

Entwicklung eines in vivo Transfektionsmodels zur induzierbaren Genexpression in murinen Hepatozyten

Metastasis development in a novel mouse model of advanced liver cancer

Ehnert, S

Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma

Eischeid, H

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Eisenacher, M

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Eisenbürger, S

Influence of HCV on CREB gene expression and functional relevance

Hepatitis C Virus activates auto- and paracrine circuits to modify surface expression of growth factor receptors of the Erb family

Eiteneuer, EM

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Elssner, C

Nuclear CYLD expression plays a role in HCC therapy response in vitro

Endris, V

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

Primary hepatic malignant epitheloid Hemangioendothelioma represent a genetically homogenous tumor entity

Engstler, J

Einfluss von Arginin auf die Entstehung einer Western Style Diät-induzierten nicht alkoholbedingten Fettlebererkrankung (NAFLD): Untersuchungen im Mausmodell

Ergen, C

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Erhart, W

Representation of human non-alcoholic fatty liver disease in murine models

Ernst, C

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Ernst, S

Biomarkers to predict the clinical outcome of hepatitis delta

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Erschfeld, S

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Esser, K

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Evert, M

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Eychmüller, A

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Fahrenkamp, D

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Falk, C

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Serum biomarker profile can predict the outcome of acute HCV infection

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Falk, CS

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Biomarkers to predict the clinical outcome of hepatitis delta

Fekete-Drimusz, N

Human adult liver stem cells generated from patient samples

Feng, T

Smad7 suppresses HCC development in a DEN induced mouse model

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Ferrer, J

Lineage fate of ductular reactions in liver injury and carcinogenesis

Feuer, R

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Fichtner-Feigl, S

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Fickert, P

Cholestasis and bile acids induce expression of the oncofetal marker Nope in adult murine hepatocytes independent of Fxr

Finkelmeier, F

25-hydroxyvitamin D deficiency is associated with infections and mortality in cirrhosis

Fischer, M

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Fischer, P

MIF shows profibrotic properties after MCD diet via NKT cell population

Flechtenmacher, C

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Fleet, JC

Vitamin D3 acts on the gut-liver-adipose tissue axis to modulate obesity and associated metabolic and inflammatory changes in diet-induced obese mice

Fleischmann-Mundt, B

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

Floege, J

Comparative analysis of C5aR and C5L2 receptor deficiency in liver and kidney fibrosis

Y-box-binding protein (YB-1) in murine models of hepatic and renal fibrosis

Folseraas, T

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Fraas, A

Novel tumor suppressor genes SORBS3 and SH2D4A repress IL-6 signaling in hepatocellular carcinoma

Fragoulis, A

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Freund, B

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Frey, A

Everolimus beeinflusst die HCV-Replikationsaktivität

Frey, L

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Friebel, A

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

Friedman, SL

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Friedrich, K

Cardiac volume overload after long-term follow-up in TIPS patients

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Friess, H

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Fuchs, P

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Führer, D

Metformin Treatment Ameliorates Liver Injury Indicating Fatty Liver Polycystic Ovary Syndrome

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Gaestel, M

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Galle, PR

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Array-based gene expression analysis of M1/M2-polarized macrophages during treatment with multi-kinase inhibitor Sorafenib

Einfluss metabolischer Faktoren auf die Prognose von Patienten mit fortgeschrittenem hepatozellulärem Karzinom unter Sorafenib Therapie

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Gao, B

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Garbi, N

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Gass, S

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Gassler, N

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Gautheron, J

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Gebhardt, R

A new modelling approach for Gli transcription factor network in hepatocytes

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Cooperation of Hedgehog and Wnt/β-Catenin signalling in regulation of steroidogenesis in the liver

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Regulation of energy metabolism in hepatocytes with induced steatosis

Gebhardt, S

Risikofaktoren für metabolische Störungen nach Lebertransplantation: Analyse von Daten nüchterner Patienten

Geffers, R

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

Integration of exome sequencing and in vivo RNAi screening identifies new cancer genes in hepatocellular carcinoma

Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma

Gehrke, N

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Geier, A

Endocytosis of the signal transducing receptor gp130 as mechanism to fine-tune IL-6 responses

Retinoic acid amplifies the FXR-dependent FGF19 gene expression in human enterocyte-like HT-29 cells by a bi-phasic mechanism

Vitamin D3 acts on the gut-liver-adipose tissue axis to modulate obesity and associated metabolic and inflammatory changes in diet-induced obese mice

Geisler, F

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Lineage fate of ductular reactions in liver injury and carcinogenesis

Gekle, M

Aldosterone stimulates the non-genomic signaling pathway of the mineralocorticoid receptor in hepatic stellate cells

Gerbes, AL

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Gerding, B

Cytotoxicity of anisidine in hepatic cell lines

Gerken, G

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Metformin Treatment Ameliorates Liver Injury Indicating Fatty Liver Polycystic Ovary Syndrome

Visceral Adipose Tissue in NAFLD and NASH Patients is Closely Associated with Liver Injury

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Everolimus beeinflusst die HCV-Replikationsaktivität

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Eine Sequenzvariation in der Bindungsstelle des Transkriptionsfaktors GATA ist verantwortlich für eine verminderte TRAIL Regulation beim humanen HCC

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Increased Lysyl oxidase-like 2 (LOXL2) gene expression accurately designates advanced liver fibrosis induced by the Hepatitis C Virus (HCV) regardless race, blood specimen or co-infection with the Human Immunodeficiency Virus (HIV)

Gertzen, CGW

Experimental validation of the predicted TGR5 binding mode model

Gevensleben, H

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Geyer, P

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Geyer, PR

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Ghadimi, M

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

Ghafoory, S

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Ghallab, A

Damage of the non parenchymal cells after acetaminophen intoxication is critical for liver regeneration

Giersch, K

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Gieseler, RK

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

Gildein, L

Vitamin D3 acts on the gut-liver-adipose tissue axis to modulate obesity and associated metabolic and inflammatory changes in diet-induced obese mice

Ginhoux, F

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Gisa, A

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Glässner, A

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Glebe, D

Protektiver HBsAg-Expressionsverlust bei HBV-transgenen Mäusen durch Methylierungen der DNA

Gockel, I

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Goeppert, B

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Goeser, F

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Goeser, T

Activation of PP2A as possible mechanism in HCC therapy

Gohlke, H

Experimental validation of the predicted TGR5 binding mode model

Gonzalez-Carmona, MA

Die Kostimulation mit CD40Ligand steigert die Immunantwort von Tumorantigen gepulsten humanen dendritischen Zellen gegenüber humanen hepatozellulären Karzinom- (HCC) und Cholangiozellulären Karzinom- (CCC) Zellen

Kombinationstherapie mit dem spezifischen Foxp3-Inhibitor P60 und einer Vakzinierung mit AdmAFP-transduzierten dendritischen Zellen im subkutanen und orthotopen murinen HCC-Tumormodell

Görg, B

Expression von Seneszenzbiomarker in mit Ammoniak behandelten kultivierten Astrozyten und in post mortem Hirngewebe von Leberzirrhosepatienten mit hepatischer Enzephalopathie

Leberspezifischer Glutaminsynthetase-Knockout induziert Hyperammonämie und oxidativen Stress im Maushirn

Expression des Multidrug Resistance Protein 4 in mit Ammoniak behandelten kultivierten Rattenastrozyten und in post mortem Hirnproben von Leberzirrhosepatienten mit HE

Zerebrale miRNA-Expressionsänderungen bei hepatischer Enzephalopathie

Görtzen, J

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Die Aktivität von cSRC bei der Leberfibrose

Gotthardt, D

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Gotthardt, DN

Cardiac volume overload after long-term follow-up in TIPS patients

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Identification and proteomic profiling of biliary exosomes

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Granzow, M

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Graß, F

Identification of CD8+ T-cell epitopes specific for hepatitis C virus genotype 4

Graumann, F

Protektiver HBsAg-Expressionsverlust bei HBV-transgenen Mäusen durch Methylierungen der DNA

Green, RM

Identification of eQTLs for hepatic Xbp1 s and Socs3 gene expression in mice fed a high-fat, high caloric diet

Greinert, R

Prevalence of hyperdynamic circulation in cirrhosis: lack of association to presence and severity of ascites

Groos, S

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Gröpper, C

The interaction of the Hepatitis C Virus with intra-cellular signaling converts EGF into a potent inducer of the production of CXCR2-ligands by the infected host cell

Gruenhage, F

Improvement of Depressive Symptoms upon Correction of Vitamin D Deficiency in Women with Chronic Liver Disease

Grüner, N

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Grunert, D

Development of delivery, targeting, and imaging strategies to improve oncolytic vesicular stomatitis virus therapy for hepatocellular carcinoma

Grünhage, F

Next generation sequencing analysis of cholestatic patients reveals high impact variation in common and rare candidate genes: Deconstructing the genetic architecture of cholestasis

Evaluation of the effect of genetic variation in the natural killer cell receptor on liver stiffness and survival in patients with chronic liver disease

Influence of vitamin D supplementation on liver function tests, vitamin D levels and liver stiffness in patients with chronic liver diseases in an outpatient setting

Guba, M

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Gul, S

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Gürlevik, E

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden

Guthke, R

A new modelling approach for Gli transcription factor network in hepatocytes

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Gutierrez Jauregui, R

Human adult liver stem cells generated from patient samples

Haas, U

Cyclin E1 expression level determines the anti-proliferative response of the pharmacological Cdk2 inhibitor Roscovitine in hepatoma cells and in the liver

Platelet-derived growth factor-D intensifies fibrogenesis through upregulation of TIMP-1 expression and signalling through both platelet-derived growth factor receptors type α and β

Hackstein, P

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Hadem, J

Increased serum levels of regenerative miRNAs in patients with spontaneous recovery from acute liver failure

Hafezi, M

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Hahn, T von

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Hahnel, MJ

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Halilbasic, E

Histopathology of chronic Hepatitis E

Hall, R

The extracellular proteinase Expi/Wfdc18 in liver damage and tumour development: A new connection between inflammation, fibrogenesis and malignant growth

Hall, RA

Identification of eQTLs for hepatic Xbp1 s and Socs3 gene expression in mice fed a high-fat, high caloric diet

Riboflavin Kinase Inhibitor 1 (RKIP1): A Potential Modifier of Fibrogenesis in Liver and Heart

Hammad, S

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

Reconstruction and quantification of periportal bile ducts and Hering canal after bile duct ligation

Hammerstingl, C

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Hampe, J

Representation of human non-alcoholic fatty liver disease in murine models

Hardtke, S

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Serum biomarker profile can predict the outcome of acute HCV infection

Biomarkers to predict the clinical outcome of hepatitis delta

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Hartig, U

Nicht-alkoholische Fettleberentzündung (NASH) – doch nur ein Problem der Energiezufuhr?

Hartl, J

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Hartmann, D

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Hasreiter, J

Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Hassan, R

Damage of the non parenchymal cells after acetaminophen intoxication is critical for liver regeneration

Hatting, M

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Hauner, M

The effect of extended transportation time on the quality of freshly isolated human liver cells

Häussinger, D

Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5

Influence of HCV on CREB gene expression and functional relevance

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Expression von Seneszenzbiomarker in mit Ammoniak behandelten kultivierten Astrozyten und in post mortem Hirngewebe von Leberzirrhosepatienten mit hepatischer Enzephalopathie

Leberspezifischer Glutaminsynthetase-Knockout induziert Hyperammonämie und oxidativen Stress im Maushirn

Hepatitis C Virus activates auto- and paracrine circuits to modify surface expression of growth factor receptors of the Erb family

Inhibition of the transcriptional regulation of CDCA-induced BSEP expression by IL-1β involves the IL-1β triggered activation of autocrine chemokine circuits

The interaction of the Hepatitis C Virus with intra-cellular signaling converts EGF into a potent inducer of the production of CXCR2-ligands by the infected host cell

Expression des Multidrug Resistance Protein 4 in mit Ammoniak behandelten kultivierten Rattenastrozyten und in post mortem Hirnproben von Leberzirrhosepatienten mit HE

Experimental validation of the predicted TGR5 binding mode model

Zerebrale miRNA-Expressionsänderungen bei hepatischer Enzephalopathie

Hepatocytes secret a mediator pattern that induces macrophage phenotype with properties of wound healing type and regulatory macrophages

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Heeren, J

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Heidrich, B

Biomarkers to predict the clinical outcome of hepatitis delta

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Heikenwälder, M

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Differential regulation of TNF receptor signaling during viral infection of hepatocytes determines cell death

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Lineage fate of ductular reactions in liver injury and carcinogenesis

Heine, A

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Heine, M

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Heinemann, F

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Heiner, W

Eligibility and safety of sofosbuvir in a real-world single center cohort of patients with advanced cirrhosis, including decompensated cirrhosis

Heinold, A

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Heinrich, S

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Heinrichs, D

MIF shows profibrotic properties after MCD diet via NKT cell population

Heinz, S

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Heinzel, K

Infizierbarkeit der Hepatom-Zelllinie HepaRG durch HBV+ Seren mit niedrigem bis hohem Virustiter

Heinzen, J

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Helfritz, F

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Hellerbrand, C

Aldosterone stimulates the non-genomic signaling pathway of the mineralocorticoid receptor in hepatic stellate cells

Hepatic steatosis promotes growth and invasiveness of hepatocellular carcinoma cells in vitro and in vivo

Identification of cytochrome CYP2E1 as critical mediator of alcohol effects on steatotic hepatocytes

ERK and p38 activation are central mediators of irinotecan-induced steatohepatitis

Representation of human non-alcoholic fatty liver disease in murine models

Fibroblast growth factor 7 inhibits hepatic steatosis, inflammation and fibrosis in murine models of on non-alcoholic steatohepatitis

Functional effects of monocarboxylate transporter 1 expression in activated hepatic stellate cells

Increased expression of the Glucose-transporter GLUT1 during hepatic stellate cell activation promotes hepatic fibrosis

Hempel, M

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Hengst, J

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Serum biomarker profile can predict the outcome of acute HCV infection

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Hengstler, JG

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

Damage of the non parenchymal cells after acetaminophen intoxication is critical for liver regeneration

Reconstruction and quantification of periportal bile ducts and Hering canal after bile duct ligation

Henkel, J

The vicious circle of prostaglandin- and cytokine-dependent hepatic insulin resistance: a key role of prostaglandin E2

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Herkel, J

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

PSC-Patienten weisen eine verminderte Apoptosesensitivität von CD4+ T-Zellen im peripheren Blut auf

Treg impairment is not a sufficient cause of autoimmune liver inflammation

Hermanns, HM

Endocytosis of the signal transducing receptor gp130 as mechanism to fine-tune IL-6 responses

Retinoic acid amplifies the FXR-dependent FGF19 gene expression in human enterocyte-like HT-29 cells by a bi-phasic mechanism

Vitamin D3 acts on the gut-liver-adipose tissue axis to modulate obesity and associated metabolic and inflammatory changes in diet-induced obese mice

Hermert, D

Y-box-binding protein (YB-1) in murine models of hepatic and renal fibrosis

Herrmann, A

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Representation of human non-alcoholic fatty liver disease in murine models

Herrmann, E

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Herzer, K

Everolimus beeinflusst die HCV-Replikationsaktivität

Eine Sequenzvariation in der Bindungsstelle des Transkriptionsfaktors GATA ist verantwortlich für eine verminderte TRAIL Regulation beim humanen HCC

Hescheler, J

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Hess, J

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Heymann, F

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Hilgard, G

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Hillebrand, RM

Die Kostimulation mit CD40Ligand steigert die Immunantwort von Tumorantigen gepulsten humanen dendritischen Zellen gegenüber humanen hepatozellulären Karzinom- (HCC) und Cholangiozellulären Karzinom- (CCC) Zellen

Hippchen, T

Cardiac volume overload after long-term follow-up in TIPS patients

Hiththetiya, K

Rolle des Mas Rezeptors in der Leberfibrose

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Höchst, B

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Hoehme, S

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

Hoeltke, N

Cyclin E1 expression level determines the anti-proliferative response of the pharmacological Cdk2 inhibitor Roscovitine in hepatoma cells and in the liver

Hoerauf, A

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Hoesl, M

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Hoffmann, AC

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Hoffmann, D

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Hoffmann, V

Activation of PP2A as possible mechanism in HCC therapy

Cholestasis and bile acids induce expression of the oncofetal marker Nope in adult murine hepatocytes independent of Fxr

Hofmann, T

Everolimus beeinflusst die HCV-Replikationsaktivität

Hofmann, U

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Reduced HNF3b (FOXA2) levels in steatosis leads to diminished expression of anti-lipoapoptotic protein ALR

Hohaus, P

Prevalence of hyperdynamic circulation in cirrhosis: lack of association to presence and severity of ascites

Hollenbach, M

Die Hemmung der Glyoxalase-I durch Ethylpyruvat vermindert die LPS-induzierte Aktivierung von hepatischen Sternzellen

Prevalence of hyperdynamic circulation in cirrhosis: lack of association to presence and severity of ascites

Holzer, K

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Holzhütter, HG

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Holzmann, B

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Holzmann, H

Histopathology of chronic Hepatitis E

Höner zu Siederdissen, C

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Clinical significance of drug-drug interactions during HCV therapy with sofosbuvir and simeprevir in comparison to first wave protease inhibitors

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Hoppe-Lotichius, M

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Horst, AK

CEACAM1 deficiency exacerbates acute liver injury in a mouse model of immune-mediated hepatitis

Hov, JR

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Hövelmeyer, N

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Hu, J

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Hu, W

Cyclin E1 expression level determines the anti-proliferative response of the pharmacological Cdk2 inhibitor Roscovitine in hepatoma cells and in the liver

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Huang, J

Promoter regulation of the miR-29a/b1 gene by transforming growth factor-β in hepatic stellate cells and in hepatoma cells

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Huber, S

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Hubner, EK

Entwicklung eines in vivo Transfektionsmodels zur induzierbaren Genexpression in murinen Hepatozyten

Metastasis development in a novel mouse model of advanced liver cancer

Hunka, L

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Hüser, N

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Idilman, R

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Ingeliz, P

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Ingiliz, P

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Inhoffen, J

Deficiency of calcium-independent phospholipase A2 beta in vivo causes systematic inflammation and hepatocellular carcinoma

Ittrich, H

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Itzel, T

Representation of human non-alcoholic fatty liver disease in murine models

Jagemann, B

Nicht-alkoholische Fettleberentzündung (NASH) – doch nur ein Problem der Energiezufuhr?

Jahn, D

Retinoic acid amplifies the FXR-dependent FGF19 gene expression in human enterocyte-like HT-29 cells by a bi-phasic mechanism

Vitamin D3 acts on the gut-liver-adipose tissue axis to modulate obesity and associated metabolic and inflammatory changes in diet-induced obese mice

Janas, M

Differential regulation of TNF receptor signaling during viral infection of hepatocytes determines cell death

Janicot, M

Targeting TGF-β2 in chronic liver diseases

Jansen, C

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Jara, M

Volumen-Funktionsplanung in der Leberchirurgie: Was kann man von der Kombination aus 3D- CT- Volumetrie mit dem LiMAx-Test erwarten?

Einfluss von akuten Komplikationen der Leberzirrhose auf die Lebensqualität von Patienten mit Leberzirrhose im Verlauf

Risikofaktoren für metabolische Störungen nach Lebertransplantation: Analyse von Daten nüchterner Patienten

Jaroszewicz, J

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Jaschinski, F

Targeting TGF-β2 in chronic liver diseases

Jeliazkova, P

Lineage fate of ductular reactions in liver injury and carcinogenesis

Jilg, W

HBsAg-specific humoral and cellular immune memory after hepatitis B booster vaccination in adolescents 10 – 15 years after immunization in infancy

Jin, C

Einfluss von Arginin auf die Entstehung einer Western Style Diät-induzierten nicht alkoholbedingten Fettlebererkrankung (NAFLD): Untersuchungen im Mausmodell

Jochum, C

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Johanen, T

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

John, C

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

John, K

Increased serum levels of regenerative miRNAs in patients with spontaneous recovery from acute liver failure

Jördens, M

Expression des Multidrug Resistance Protein 4 in mit Ammoniak behandelten kultivierten Rattenastrozyten und in post mortem Hirnproben von Leberzirrhosepatienten mit HE

Jörs, S

Lineage fate of ductular reactions in liver injury and carcinogenesis

Jüngst, C

Next generation sequencing analysis of cholestatic patients reveals high impact variation in common and rare candidate genes: Deconstructing the genetic architecture of cholestasis

Kaczmarek, D

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Kaiser, G

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Kampschulte, M

Quantitative Analyse der Tumor-Vaskularisation mittels Mikro-CT in ApoE/LDLR Doppel-Knockout Mäusen unter Western-Diät

Kanwal, S

Damage and recovery of hepatic tissue of Mus musculus inhabited at metallurgical workshop

Karababa, A

Expression von Seneszenzbiomarker in mit Ammoniak behandelten kultivierten Astrozyten und in post mortem Hirngewebe von Leberzirrhosepatienten mit hepatischer Enzephalopathie

Karimi, K

An additional heme oxygenase-1 knockout increases maturation of dendritic cells and liver inflammation in mdr2 knockout mice

Kaspar, M

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Kasper, HU

Phenprocoumon-induced liver injury

Kastenmüller, W

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Katsounas, A

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Increased Lysyl oxidase-like 2 (LOXL2) gene expression accurately designates advanced liver fibrosis induced by the Hepatitis C Virus (HCV) regardless race, blood specimen or co-infection with the Human Immunodeficiency Virus (HIV)

Kaufmann, R

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Kawelke, N

Loss of Integrin-β1 in Hepatocytes Induces Liver Fibrosis

Inflammatory cell infiltration in experimental liver fibrosis is affected by inhibition of fibronectin matrix assembly

Kazakov, A

Riboflavin Kinase Inhibitor 1 (RKIP1): A Potential Modifier of Fibrogenesis in Liver and Heart

Kefalakes, H

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Keitel, V

Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5

Expression des Multidrug Resistance Protein 4 in mit Ammoniak behandelten kultivierten Rattenastrozyten und in post mortem Hirnproben von Leberzirrhosepatienten mit HE

Experimental validation of the predicted TGR5 binding mode model

Keller, DA

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Kempa, S

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Keskin, O

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Kesselring, R

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Kettelhake, A

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Khairzada, K

Eine Sequenzvariation in der Bindungsstelle des Transkriptionsfaktors GATA ist verantwortlich für eine verminderte TRAIL Regulation beim humanen HCC

Khawar, B

Damage and recovery of hepatic tissue of Mus musculus inhabited at metallurgical workshop

Kim, AY

Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype

Kim, YO

Representation of human non-alcoholic fatty liver disease in murine models

Kiraithe, M

Dominance of HLA-B restricted virus-specific CD8+ T cell epitopes in chronic HBV infection

Kirchstein, A

Volumen-Funktionsplanung in der Leberchirurgie: Was kann man von der Kombination aus 3D- CT- Volumetrie mit dem LiMAx-Test erwarten?

Kirschner, J

Biomarkers to predict the clinical outcome of hepatitis delta

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Klaus, C

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Kleeff, J

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Klein, S

Rolle des Mas Rezeptors in der Leberfibrose

Die Aktivität von cSRC bei der Leberfibrose

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Kleinehr, K

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Kleuser, B

Enhanced Phenobarbital-induced Thyroid Hormone Breakdown in Hepatocytes by Benzo[a]pyren-dependent Induction of the Constitutive Androstane Receptor

Klingmüller, U

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

Kloeters-Plachky, P

Identification and proteomic profiling of biliary exosomes

Kluwe, J

Nicht-alkoholische Fettleberentzündung (NASH) – doch nur ein Problem der Energiezufuhr?

Bacterial infection is a common complication in patients with severe alcoholic hepatitis

Knapstein, J

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Knauel, M

MIF shows profibrotic properties after MCD diet via NKT cell population

Knierim, J

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Knocke, S

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

Knodel, MM

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Knoefel, WT

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Knolle, P

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Differential regulation of TNF receptor signaling during viral infection of hepatocytes determines cell death

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

Knolle, PA

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Knüchel, R

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Koch, A

Biomarkers to predict the clinical outcome of hepatitis delta

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Hepatic steatosis promotes growth and invasiveness of hepatocellular carcinoma cells in vitro and in vivo

Increased expression of the Glucose-transporter GLUT1 during hepatic stellate cell activation promotes hepatic fibrosis

Koch, S

Einfluss metabolischer Faktoren auf die Prognose von Patienten mit fortgeschrittenem hepatozellulärem Karzinom unter Sorafenib Therapie

Koehler, BC

Nuclear CYLD expression plays a role in HCC therapy response in vitro

Koenig, S

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

Kohlhepp, M

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Kohnke-Ertel, B

Entwicklung eines in vivo Transfektionsmodels zur induzierbaren Genexpression in murinen Hepatozyten

Metastasis development in a novel mouse model of advanced liver cancer

Koitzsch, U

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Kokai, E

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Kokordelis, P

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

König, A

Influence of vitamin D supplementation on liver function tests, vitamin D levels and liver stiffness in patients with chronic liver diseases in an outpatient setting

Korhonen, H

Targeting TGF-β2 in chronic liver diseases

Korn, T

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Kottilil, S

Increased Lysyl oxidase-like 2 (LOXL2) gene expression accurately designates advanced liver fibrosis induced by the Hepatitis C Virus (HCV) regardless race, blood specimen or co-infection with the Human Immunodeficiency Virus (HIV)

Kraft, A

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Krämer, B

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Kraus, M

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Kraus, MR

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Krause, P

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

Krawczyk, M

Serum sterol levels indicate distorted cholesterol homeostasis in cirrhotic patients with primary biliary cirrhosis

Evaluation of the effect of genetic variation in the natural killer cell receptor on liver stiffness and survival in patients with chronic liver disease

Kreipe, H

Histopathology of chronic Hepatitis E

Kreisel, W

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Kreuels, B

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Kristy, A

Identification of eQTLs for hepatic Xbp1 s and Socs3 gene expression in mice fed a high-fat, high caloric diet

Kronenberger, B

25-hydroxyvitamin D deficiency is associated with infections and mortality in cirrhosis

Kroy, D

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Kubicka, S

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden

Kühne, C

Infizierbarkeit der Hepatom-Zelllinie HepaRG durch HBV+ Seren mit niedrigem bis hohem Virustiter

Kühnel, F

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden

Kurts, C

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Kuttkat, N

Pharmakologische oder genetische Intervention des CCL5/RANTES Signalweges im in vivo Modell einer chronischer Leberentzündung vermindert die Fibrogenese und Progression zum Hepatozellulären Karzinom

Laleman, W

Die Aktivität von cSRC bei der Leberfibrose

Lambertz, D

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Lammert, F

Prevalence of hepatic steatosis in healthy health care workers as quantified by controlled attenuation parameter (CAP)

Next generation sequencing analysis of cholestatic patients reveals high impact variation in common and rare candidate genes: Deconstructing the genetic architecture of cholestasis

Identification of eQTLs for hepatic Xbp1 s and Socs3 gene expression in mice fed a high-fat, high caloric diet

Improvement of Depressive Symptoms upon Correction of Vitamin D Deficiency in Women with Chronic Liver Disease

Comparative analysis of C5aR and C5L2 receptor deficiency in liver and kidney fibrosis

Serum sterol levels indicate distorted cholesterol homeostasis in cirrhotic patients with primary biliary cirrhosis

Riboflavin Kinase Inhibitor 1 (RKIP1): A Potential Modifier of Fibrogenesis in Liver and Heart

The extracellular proteinase Expi/Wfdc18 in liver damage and tumour development: A new connection between inflammation, fibrogenesis and malignant growth

Evaluation of the effect of genetic variation in the natural killer cell receptor on liver stiffness and survival in patients with chronic liver disease

Influence of vitamin D supplementation on liver function tests, vitamin D levels and liver stiffness in patients with chronic liver diseases in an outpatient setting

Progranulin autoantibodies and genetic variation in patients with cholangiocarcinoma

Lang, H

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Array-based gene expression analysis of M1/M2-polarized macrophages during treatment with multi-kinase inhibitor Sorafenib

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Lang, J

Dominance of HLA-B restricted virus-specific CD8+ T cell epitopes in chronic HBV infection

Lang, P

Leberspezifischer Glutaminsynthetase-Knockout induziert Hyperammonämie und oxidativen Stress im Maushirn

Langhans, B

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Langner, C

Phenprocoumon-induced liver injury

Laschtowitz, A

Treg impairment is not a sufficient cause of autoimmune liver inflammation

Lauer, GM

Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype

Laufs, U

Riboflavin Kinase Inhibitor 1 (RKIP1): A Potential Modifier of Fibrogenesis in Liver and Heart

Lautem, A

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Lechler, C

Entwicklung eines in vivo Transfektionsmodels zur induzierbaren Genexpression in murinen Hepatozyten

Metastasis development in a novel mouse model of advanced liver cancer

Lee, SML

The effect of extended transportation time on the quality of freshly isolated human liver cells

Lehmann, J

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Lehmann, P

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Leibiger, K

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Leithäuser, F

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Leopold, Y

Identification and proteomic profiling of biliary exosomes

Lewis-Ximenez, L

Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype

Li, Y

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Liebe, R

Next generation sequencing analysis of cholestatic patients reveals high impact variation in common and rare candidate genes: Deconstructing the genetic architecture of cholestasis

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

The extracellular proteinase Expi/Wfdc18 in liver damage and tumour development: A new connection between inflammation, fibrogenesis and malignant growth

Liebscher, T

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Liedtke, C

Cyclin E1 expression level determines the anti-proliferative response of the pharmacological Cdk2 inhibitor Roscovitine in hepatoma cells and in the liver

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

NLRP3 inflammasome expression in cultured hepatocytes is regulated by nuclear factor-κB (NF-κB)

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Lieske, S

Xenobiotic-dependent induction of the tricarboxylate carrier Slc13a5 in primary cultures of rat hepatocytes

The vicious circle of prostaglandin- and cytokine-dependent hepatic insulin resistance: a key role of prostaglandin E2

Liu, Y

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Llanto, C

Non-responsiveness to therapeutic tumor vaccination is overcome by functional modulation of myeloid derived suppressor cells

Locker, J

Engraftment and transdifferentiation of ectopic transplanted mature hepatocytes in a liver environment with ongoing biliary fibrosis

Lohmann, V

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Löhr, H

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Löhr, HF

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Lohse, A

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Histopathology of chronic Hepatitis E

Lohse, AW

Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Nicht-alkoholische Fettleberentzündung (NASH) – doch nur ein Problem der Energiezufuhr?

PSC-Patienten weisen eine verminderte Apoptosesensitivität von CD4+ T-Zellen im peripheren Blut auf

Assoziation von Autoantikörpern und Symptomen bei der Primär Biliären Zirrhose (PBC)

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Bacterial infection is a common complication in patients with severe alcoholic hepatitis

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Treg impairment is not a sufficient cause of autoimmune liver inflammation

Longerich, T

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Integration of exome sequencing and in vivo RNAi screening identifies new cancer genes in hepatocellular carcinoma

Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Loscher, C

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Lu, M

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Luch, A

Cytotoxicity of anisidine in hepatic cell lines

An in vitro system for the identification of DILI related signaling?

Luciano, L

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Ludwig-Portugall, I

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Luedde, T

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Lupke, M

Reduced HNF3b (FOXA2) levels in steatosis leads to diminished expression of anti-lipoapoptotic protein ALR

Lütgehetmann, M

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Lüth, S

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Infizierbarkeit der Hepatom-Zelllinie HepaRG durch HBV+ Seren mit niedrigem bis hohem Virustiter

Lütjohann, D

Serum sterol levels indicate distorted cholesterol homeostasis in cirrhotic patients with primary biliary cirrhosis

Lutterbeck, M

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Lutz, P

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Lutz, T

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Luxenburger, H

Identification of CD8+ T-cell epitopes specific for hepatitis C virus genotype 4

Maasoumy, B

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Clinical significance of drug-drug interactions during HCV therapy with sofosbuvir and simeprevir in comparison to first wave protease inhibitors

Eligibility and safety of sofosbuvir in a real-world single center cohort of patients with advanced cirrhosis, including decompensated cirrhosis

Maass, T

Smad7 suppresses HCC development in a DEN induced mouse model

Macheleidt, I

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Mahli, A

Identification of cytochrome CYP2E1 as critical mediator of alcohol effects on steatotic hepatocytes

ERK and p38 activation are central mediators of irinotecan-induced steatohepatitis

Mai, M

A common polymorphism of tumor necrosis factor receptor-associated factor 6 (TRAF6) is associated with an increased risk for spontaneous bacterial peritonitis

Mais, C

Endocytosis of the signal transducing receptor gp130 as mechanism to fine-tune IL-6 responses

Malinowski, M

Volumen-Funktionsplanung in der Leberchirurgie: Was kann man von der Kombination aus 3D- CT- Volumetrie mit dem LiMAx-Test erwarten?

Risikofaktoren für metabolische Störungen nach Lebertransplantation: Analyse von Daten nüchterner Patienten

Mandorfer, M

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Manka, P

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Mann, A

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Manns, M

Histopathology of chronic Hepatitis E

Increased serum levels of regenerative miRNAs in patients with spontaneous recovery from acute liver failure

Manns, MP

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Serum biomarker profile can predict the outcome of acute HCV infection

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Biomarkers to predict the clinical outcome of hepatitis delta

Clinical significance of drug-drug interactions during HCV therapy with sofosbuvir and simeprevir in comparison to first wave protease inhibitors

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Human adult liver stem cells generated from patient samples

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Eligibility and safety of sofosbuvir in a real-world single center cohort of patients with advanced cirrhosis, including decompensated cirrhosis

p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden

Manowsky, J

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Marbach, E

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Marhenke, S

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Markova, AA

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Marquardt, J

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Array-based gene expression analysis of M1/M2-polarized macrophages during treatment with multi-kinase inhibitor Sorafenib

Einfluss metabolischer Faktoren auf die Prognose von Patienten mit fortgeschrittenem hepatozellulärem Karzinom unter Sorafenib Therapie

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Marquardt, JU

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Martin, C

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Martin, IV

Comparative analysis of C5aR and C5L2 receptor deficiency in liver and kidney fibrosis

Martin, M

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Masing, N

Rolle des Mas Rezeptors in der Leberfibrose

Mastrobuoni, G

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Mathé, Z

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Matusch, A

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

Matz-Soja, M

A new modelling approach for Gli transcription factor network in hepatocytes

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Cooperation of Hedgehog and Wnt/β-Catenin signalling in regulation of steroidogenesis in the liver

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Regulation of energy metabolism in hepatocytes with induced steatosis

Megger, DA

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Mehrabi, A

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Meindl-Beinker, N

Targeting TGF-β2 in chronic liver diseases

Meindl-Beinker, NM

Smad7 suppresses HCC development in a DEN induced mouse model

Meissner, EG

Increased Lysyl oxidase-like 2 (LOXL2) gene expression accurately designates advanced liver fibrosis induced by the Hepatitis C Virus (HCV) regardless race, blood specimen or co-infection with the Human Immunodeficiency Virus (HIV)

Melter, M

Reduced HNF3b (FOXA2) levels in steatosis leads to diminished expression of anti-lipoapoptotic protein ALR

Hepatic detoxification and anti-oxidative response in liver tissue with cholestasis: analysis of Nrf2 dependent gene expression

Merle, U

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

Meurer, SK

Platelet-derived growth factor-D intensifies fibrogenesis through upregulation of TIMP-1 expression and signalling through both platelet-derived growth factor receptors type α and β

Meyer, AS

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Meyer, ASK

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Meyer, HE

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Michael, MP

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Michler, T

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Milkiewicz, P

Serum sterol levels indicate distorted cholesterol homeostasis in cirrhotic patients with primary biliary cirrhosis

Missing, L

Inhibition of the transcriptional regulation of CDCA-induced BSEP expression by IL-1β involves the IL-1β triggered activation of autocrine chemokine circuits

Mix, C

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Moeller, LC

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Mogler, C

Primary hepatic malignant epitheloid Hemangioendothelioma represent a genetically homogenous tumor entity

Mohs, A

Pharmakologische oder genetische Intervention des CCL5/RANTES Signalweges im in vivo Modell einer chronischer Leberentzündung vermindert die Fibrogenese und Progression zum Hepatozellulären Karzinom

Moldenhauer, G

Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Momburg, F

Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Moriconi, F

HMGB1 inflammosome activity modulates HIF-1α in a rat model of thioacetamide (TAA)-induced chronic liver damage and cholangiocarcinoma development

Moro, N

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Morton, CH

Cholestasis and bile acids induce expression of the oncofetal marker Nope in adult murine hepatocytes independent of Fxr

Müller, J

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Müller, M

Identification of cytochrome CYP2E1 as critical mediator of alcohol effects on steatotic hepatocytes

ERK and p38 activation are central mediators of irinotecan-induced steatohepatitis

Functional effects of monocarboxylate transporter 1 expression in activated hepatic stellate cells

Müller-Newen, G

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Muñoz Álvarez, KA

Development of delivery, targeting, and imaging strategies to improve oncolytic vesicular stomatitis virus therapy for hepatocellular carcinoma

Münst, B

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Münzberg, C

Aldosterone stimulates the non-genomic signaling pathway of the mineralocorticoid receptor in hepatic stellate cells

Nägel, A

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Nakchbandi, IA

Loss of Integrin-β1 in Hepatocytes Induces Liver Fibrosis

Inflammatory cell infiltration in experimental liver fibrosis is affected by inhibition of fibronectin matrix assembly

Nattermann, J

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Naumann, U

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Neuber, C

Enhanced Phenobarbital-induced Thyroid Hormone Breakdown in Hepatocytes by Benzo[a]pyren-dependent Induction of the Constitutive Androstane Receptor

Neumann, O

Integration of exome sequencing and in vivo RNAi screening identifies new cancer genes in hepatocellular carcinoma

Neumann-Haefelin, C

Identification of CD8+ T-cell epitopes specific for hepatitis C virus genotype 4

Presence of naive-like HBV-specific CD8+ T cells in chronically infected patients despite ongoing viral replication

Dominance of HLA-B restricted virus-specific CD8+ T cell epitopes in chronic HBV infection

Neuschäfer-Rube, F

Enhanced Phenobarbital-induced Thyroid Hormone Breakdown in Hepatocytes by Benzo[a]pyren-dependent Induction of the Constitutive Androstane Receptor

Xenobiotic-dependent induction of the tricarboxylate carrier Slc13a5 in primary cultures of rat hepatocytes

Nevzorova, YA

Cyclin E1 expression level determines the anti-proliferative response of the pharmacological Cdk2 inhibitor Roscovitine in hepatoma cells and in the liver

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Nickenig, G

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Niebert, S

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

Nielsen, P

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Niemietz, P

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Nierhoff, D

Activation of PP2A as possible mechanism in HCC therapy

Cholestasis and bile acids induce expression of the oncofetal marker Nope in adult murine hepatocytes independent of Fxr

Nischalke, HD

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Nitschke, K

Identification of CD8+ T-cell epitopes specific for hepatitis C virus genotype 4

Noetel, A

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Nordheim, A

Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma

Nuessler, AK

Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma

Ochando, J

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Odenthal, M

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Promoter regulation of the miR-29a/b1 gene by transforming growth factor-β in hepatic stellate cells and in hepatoma cells

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Oenarto, J

Zerebrale miRNA-Expressionsänderungen bei hepatischer Enzephalopathie

Oertel, M

Engraftment and transdifferentiation of ectopic transplanted mature hepatocytes in a liver environment with ongoing biliary fibrosis

Ori, A

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Ostendorf, T

Comparative analysis of C5aR and C5L2 receptor deficiency in liver and kidney fibrosis

Y-box-binding protein (YB-1) in murine models of hepatic and renal fibrosis

Othman, A

Three-dimensional reconstruction and quantification of key features of liver microarchitecture

Owusu, SS

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Pannicke, N

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Park, O

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Pathe-Neuschäfer-Rube, A

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Pathil, A

UDCA-LPE modulates different signaling pathways involved in hepatic fibrogenesis

Pathil-Warth, A

Lysophosphatidylcholine (LPC) as central player for hepatic fat accumulation and inflammation: implication for the pathogenesis of NASH

Paul, A

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Eine Sequenzvariation in der Bindungsstelle des Transkriptionsfaktors GATA ist verantwortlich für eine verminderte TRAIL Regulation beim humanen HCC

Peck-Radosavljevic, M

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Peiseler, M

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Pellegrino, R

Integration of exome sequencing and in vivo RNAi screening identifies new cancer genes in hepatocellular carcinoma

Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma

Peng, J

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Penzel, R

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

Primary hepatic malignant epitheloid Hemangioendothelioma represent a genetically homogenous tumor entity

Perner, D

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

Perrech, M

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Petersen, C

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Petersen, J

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Peusquens, J

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Pfarr, N

Primary hepatic malignant epitheloid Hemangioendothelioma represent a genetically homogenous tumor entity

Pfeiffenberger, J

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Pfreundschuh, M

Progranulin autoantibodies and genetic variation in patients with cholangiocarcinoma

Piiper, A

25-hydroxyvitamin D deficiency is associated with infections and mortality in cirrhosis

Pikarsky, E

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Pilo, MG

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

Pinna, F

A20(TNFAIP3) as modulator of TNFα-induced responses in mouse hepatoma cell lines and primary mouse hepatocytes

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Piras-Straub, K

Everolimus beeinflusst die HCV-Replikationsaktivität

Eine Sequenzvariation in der Bindungsstelle des Transkriptionsfaktors GATA ist verantwortlich für eine verminderte TRAIL Regulation beim humanen HCC

Pischke, S

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Histopathology of chronic Hepatitis E

Plass, C

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Plöger, C

Novel tumor suppressor genes SORBS3 and SH2D4A repress IL-6 signaling in hepatocellular carcinoma

Pohl, S

Die Hemmung der Glyoxalase-I durch Ethylpyruvat vermindert die LPS-induzierte Aktivierung von hepatischen Sternzellen

Polywka, S

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Port, K

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Clinical significance of drug-drug interactions during HCV therapy with sofosbuvir and simeprevir in comparison to first wave protease inhibitors

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Eligibility and safety of sofosbuvir in a real-world single center cohort of patients with advanced cirrhosis, including decompensated cirrhosis

Pozdeev, V

Leberspezifischer Glutaminsynthetase-Knockout induziert Hyperammonämie und oxidativen Stress im Maushirn

Pratschke, J

Volumen-Funktionsplanung in der Leberchirurgie: Was kann man von der Kombination aus 3D- CT- Volumetrie mit dem LiMAx-Test erwarten?

Einfluss von akuten Komplikationen der Leberzirrhose auf die Lebensqualität von Patienten mit Leberzirrhose im Verlauf

Risikofaktoren für metabolische Störungen nach Lebertransplantation: Analyse von Daten nüchterner Patienten

Pratschke, S

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Presonil, V

Einfluss metabolischer Faktoren auf die Prognose von Patienten mit fortgeschrittenem hepatozellulärem Karzinom unter Sorafenib Therapie

Protzer, U

Liver sinusoidal endothelial cells and Kupffer cells contribute to HCV innate immune response via TLR3

Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Type III interferons induce cccDNA degradation similar to type I interferons in HBV-infected HepaRG cells

Proudfoot Fichard, A

Pharmakologische oder genetische Intervention des CCL5/RANTES Signalweges im in vivo Modell einer chronischer Leberentzündung vermindert die Fibrogenese und Progression zum Hepatozellulären Karzinom

Puhl, G

Risikofaktoren für metabolische Störungen nach Lebertransplantation: Analyse von Daten nüchterner Patienten

Pukrop, T

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

Püschel, GP

Enhanced Phenobarbital-induced Thyroid Hormone Breakdown in Hepatocytes by Benzo[a]pyren-dependent Induction of the Constitutive Androstane Receptor

Xenobiotic-dependent induction of the tricarboxylate carrier Slc13a5 in primary cultures of rat hepatocytes

The vicious circle of prostaglandin- and cytokine-dependent hepatic insulin resistance: a key role of prostaglandin E2

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Pusterla, T

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Quaas, A

An additional heme oxygenase-1 knockout increases maturation of dendritic cells and liver inflammation in mdr2 knockout mice

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Quitt, O

Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells

Qvartskhava, N

Leberspezifischer Glutaminsynthetase-Knockout induziert Hyperammonämie und oxidativen Stress im Maushirn

Radeleff, B

Cardiac volume overload after long-term follow-up in TIPS patients

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Räder, M

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

Radke, C

Verbesserte Früherkennung der Leberbeteiligung bei Mukoviszidose

Raffetseder, U

Y-box-binding protein (YB-1) in murine models of hepatic and renal fibrosis

Ramachandran, SD

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Ramadori, P

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Randolph, G

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Raskopf, E

Die Kostimulation mit CD40Ligand steigert die Immunantwort von Tumorantigen gepulsten humanen dendritischen Zellen gegenüber humanen hepatozellulären Karzinom- (HCC) und Cholangiozellulären Karzinom- (CCC) Zellen

Rath, T

Verbesserte Früherkennung der Leberbeteiligung bei Mukoviszidose

Real, CI

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Reiberger, T

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Reif, R

Damage of the non parenchymal cells after acetaminophen intoxication is critical for liver regeneration

Reimer, R

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Reisinger, F

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Reiter, S

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Renner, M

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Rennert, C

Cooperation of Hedgehog and Wnt/β-Catenin signalling in regulation of steroidogenesis in the liver

Rentsch, M

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Reuken, P

A common polymorphism of tumor necrosis factor receptor-associated factor 6 (TRAF6) is associated with an increased risk for spontaneous bacterial peritonitis

Ribback, S

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Richter, B

Reconstruction and quantification of periportal bile ducts and Hering canal after bile duct ligation

Riedl, P

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Riemenschneider, M

Improvement of Depressive Symptoms upon Correction of Vitamin D Deficiency in Women with Chronic Liver Disease

Ringel, S

Enhanced Phenobarbital-induced Thyroid Hormone Breakdown in Hepatocytes by Benzo[a]pyren-dependent Induction of the Constitutive Androstane Receptor

Ringelhan, M

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Lineage fate of ductular reactions in liver injury and carcinogenesis

Ripoll, C

Die Hemmung der Glyoxalase-I durch Ethylpyruvat vermindert die LPS-induzierte Aktivierung von hepatischen Sternzellen

Prevalence of hyperdynamic circulation in cirrhosis: lack of association to presence and severity of ascites

Rockstroh, J

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Rockstroh, JK

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Röder, R

Development of delivery, targeting, and imaging strategies to improve oncolytic vesicular stomatitis virus therapy for hepatocellular carcinoma

Roderfeld, M

Verbesserte Früherkennung der Leberbeteiligung bei Mukoviszidose

Protektiver HBsAg-Expressionsverlust bei HBV-transgenen Mäusen durch Methylierungen der DNA

Regulation der Expression von MMPs und TIMPs nach Transplantation von mesenchymalen Stammzellen im Rattenmodell der chronisch-toxischen Leberschädigung

Verstärkte hepatische Expression neuer MicroRNA bei ABCB4-/- Mäusen im Langzeitmodell

Quantitative Analyse der Tumor-Vaskularisation mittels Mikro-CT in ApoE/LDLR Doppel-Knockout Mäusen unter Western-Diät

Roeb, E

Verbesserte Früherkennung der Leberbeteiligung bei Mukoviszidose

Protektiver HBsAg-Expressionsverlust bei HBV-transgenen Mäusen durch Methylierungen der DNA

Regulation der Expression von MMPs und TIMPs nach Transplantation von mesenchymalen Stammzellen im Rattenmodell der chronisch-toxischen Leberschädigung

Verstärkte hepatische Expression neuer MicroRNA bei ABCB4-/- Mäusen im Langzeitmodell

Quantitative Analyse der Tumor-Vaskularisation mittels Mikro-CT in ApoE/LDLR Doppel-Knockout Mäusen unter Western-Diät

Roessler, S

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Rohr, M

Influence of HCV on CREB gene expression and functional relevance

Rolle, S

Einfluss von akuten Komplikationen der Leberzirrhose auf die Lebensqualität von Patienten mit Leberzirrhose im Verlauf

Rössler, A

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Rössler, S

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Novel tumor suppressor genes SORBS3 and SH2D4A repress IL-6 signaling in hepatocellular carcinoma

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Rubner, C

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Ruemmele, P

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Rührup, J

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Rupp, AK

Identification and proteomic profiling of biliary exosomes

Rupp, C

Cardiac volume overload after long-term follow-up in TIPS patients

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Identification and proteomic profiling of biliary exosomes

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Rupp, D

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

Rupp, M

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Russo, C

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Saborowski, M

p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden

Sage, J

Entwicklung eines in vivo Transfektionsmodels zur induzierbaren Genexpression in murinen Hepatozyten

Metastasis development in a novel mouse model of advanced liver cancer

Sahin, A

Hepatic detoxification and anti-oxidative response in liver tissue with cholestasis: analysis of Nrf2 dependent gene expression

Sajadian, SO

Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma

Sales, S

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Salmen, SC

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Sander, M

Lineage fate of ductular reactions in liver injury and carcinogenesis

Sandmann, M

An additional heme oxygenase-1 knockout increases maturation of dendritic cells and liver inflammation in mdr2 knockout mice

Sanwald, J

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Saric, T

The pluripotency involved factors, Lin28 and Notch1 are targets of neuronal miRNAs in hepatic stellate cells

Sarina, P

Identification of eQTLs for hepatic Xbp1 s and Socs3 gene expression in mice fed a high-fat, high caloric diet

Sarrazin, C

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

Sass, G

An additional heme oxygenase-1 knockout increases maturation of dendritic cells and liver inflammation in mdr2 knockout mice

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Sauer, I

The vicious circle of prostaglandin- and cytokine-dependent hepatic insulin resistance: a key role of prostaglandin E2

Sauer, P

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Identification and proteomic profiling of biliary exosomes

Sauerbruch, T

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Rolle des Mas Rezeptors in der Leberfibrose

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Saugspier, M

ERK and p38 activation are central mediators of irinotecan-induced steatohepatitis

Increased expression of the Glucose-transporter GLUT1 during hepatic stellate cell activation promotes hepatic fibrosis

Sawodny, O

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Schad, A

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Schafmeier, C

Representation of human non-alcoholic fatty liver disease in murine models

Schanze, N

The vicious circle of prostaglandin- and cytokine-dependent hepatic insulin resistance: a key role of prostaglandin E2

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Schattenberg, J

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Schattenberg, JM

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Schemmer, P

Cardiac volume overload after long-term follow-up in TIPS patients

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Scherr, AL

Nuclear CYLD expression plays a role in HCC therapy response in vitro

Scheurich, C

Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype

Schewe, B

Enhanced Phenobarbital-induced Thyroid Hormone Breakdown in Hepatocytes by Benzo[a]pyren-dependent Induction of the Constitutive Androstane Receptor

Schiergens, T

The effect of extended transportation time on the quality of freshly isolated human liver cells

Schierwagen, R

Rolle des Mas Rezeptors in der Leberfibrose

Die Aktivität von cSRC bei der Leberfibrose

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Schildberg, F

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

Schirmacher, P

A20(TNFAIP3) as modulator of TNFα-induced responses in mouse hepatoma cell lines and primary mouse hepatocytes

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Phenprocoumon-induced liver injury

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Novel tumor suppressor genes SORBS3 and SH2D4A repress IL-6 signaling in hepatocellular carcinoma

Integration of exome sequencing and in vivo RNAi screening identifies new cancer genes in hepatocellular carcinoma

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Primary hepatic malignant epitheloid Hemangioendothelioma represent a genetically homogenous tumor entity

Schirmbeck, R

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Schirmer, K

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Schirmer, P

p53/telomerase-dependent oncolytic adenoviruses harboring a p53-dependent feed forward loop results in reduced viral liver burden

Schlaak, JF

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Increased Lysyl oxidase-like 2 (LOXL2) gene expression accurately designates advanced liver fibrosis induced by the Hepatitis C Virus (HCV) regardless race, blood specimen or co-infection with the Human Immunodeficiency Virus (HIV)

Schlabe, S

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Schlaphoff, V

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Serum biomarker profile can predict the outcome of acute HCV infection

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Schlattjan, M

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Visceral Adipose Tissue in NAFLD and NASH Patients is Closely Associated with Liver Injury

Schlitt, HJ

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Schlitter, AM

Primary hepatic malignant epitheloid Hemangioendothelioma represent a genetically homogenous tumor entity

Schlue, J

Histopathology of chronic Hepatitis E

Schmid, RM

Entwicklung eines in vivo Transfektionsmodels zur induzierbaren Genexpression in murinen Hepatozyten

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Metastasis development in a novel mouse model of advanced liver cancer

Lineage fate of ductular reactions in liver injury and carcinogenesis

Schmidt, L

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Schmidt, SC

Volumen-Funktionsplanung in der Leberchirurgie: Was kann man von der Kombination aus 3D- CT- Volumetrie mit dem LiMAx-Test erwarten?

Schmidt-Heck, W

A new modelling approach for Gli transcription factor network in hepatocytes

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Schmidt-Wolf, I

Die Kostimulation mit CD40Ligand steigert die Immunantwort von Tumorantigen gepulsten humanen dendritischen Zellen gegenüber humanen hepatozellulären Karzinom- (HCC) und Cholangiozellulären Karzinom- (CCC) Zellen

Kombinationstherapie mit dem spezifischen Foxp3-Inhibitor P60 und einer Vakzinierung mit AdmAFP-transduzierten dendritischen Zellen im subkutanen und orthotopen murinen HCC-Tumormodell

Schmitt, J

Retinoic acid amplifies the FXR-dependent FGF19 gene expression in human enterocyte-like HT-29 cells by a bi-phasic mechanism

Vitamin D3 acts on the gut-liver-adipose tissue axis to modulate obesity and associated metabolic and inflammatory changes in diet-induced obese mice

Schneider, U

Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα

Schneller, D

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Schoknecht, T

PSC-Patienten weisen eine verminderte Apoptosesensitivität von CD4+ T-Zellen im peripheren Blut auf

Scholten, D

Specific Endoglin deletion in primary mouse hepatic stellate cells shows a modulation of TGF-b signaling pathways, aggravating liver fibrosis

Endoglin Knockdown inhibits Proliferation and NO Production in murine Sinusoidal Endothelial Cells in vitro

Schömig, E

Phenprocoumon-induced liver injury

Schönefeld, K

Regulation of energy metabolism in hepatocytes with induced steatosis

Schönfels, W von

Representation of human non-alcoholic fatty liver disease in murine models

Schott, E

Einfluss von akuten Komplikationen der Leberzirrhose auf die Lebensqualität von Patienten mit Leberzirrhose im Verlauf

Schramm, C

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

PSC-Patienten weisen eine verminderte Apoptosesensitivität von CD4+ T-Zellen im peripheren Blut auf

Assoziation von Autoantikörpern und Symptomen bei der Primär Biliären Zirrhose (PBC)

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Treg impairment is not a sufficient cause of autoimmune liver inflammation

Schraplau, A

Enhanced Phenobarbital-induced Thyroid Hormone Breakdown in Hepatocytes by Benzo[a]pyren-dependent Induction of the Constitutive Androstane Receptor

Schreiber, S

Representation of human non-alcoholic fatty liver disease in murine models

Schreiter, T

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

Schröder, D

Protektiver HBsAg-Expressionsverlust bei HBV-transgenen Mäusen durch Methylierungen der DNA

Schuch, A

Presence of naive-like HBV-specific CD8+ T cells in chronically infected patients despite ongoing viral replication

Schueler, R

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Schulte am Esch, J

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Schultze, JL

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Schulze-Bergkamen, H

Nuclear CYLD expression plays a role in HCC therapy response in vitro

Schulze-Osthoff, K

Increased serum levels of regenerative miRNAs in patients with spontaneous recovery from acute liver failure

Schulze zur Wiesch, J

Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype

Infizierbarkeit der Hepatom-Zelllinie HepaRG durch HBV+ Seren mit niedrigem bis hohem Virustiter

Increased expression of CD39 on natural killer cells in patients with chronic hepatitis C is associated with an immature phenotype

Schumacher, F

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Schuppan, D

Representation of human non-alcoholic fatty liver disease in murine models

Schütz, E

Rolle des Mas Rezeptors in der Leberfibrose

Schwabl, P

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Schweinsberg, V

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Schwill, F

Regulation der Expression von MMPs und TIMPs nach Transplantation von mesenchymalen Stammzellen im Rattenmodell der chronisch-toxischen Leberschädigung

Schwinge, D

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

PSC-Patienten weisen eine verminderte Apoptosesensitivität von CD4+ T-Zellen im peripheren Blut auf

Sebode, M

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Seehofer, D

Volumen-Funktionsplanung in der Leberchirurgie: Was kann man von der Kombination aus 3D- CT- Volumetrie mit dem LiMAx-Test erwarten?

Risikofaktoren für metabolische Störungen nach Lebertransplantation: Analyse von Daten nüchterner Patienten

Seelaender, M

Impairment of insulin signaling in hepatocytes by supernatants of insulin-activated macrophages

Seibel, P

Regulation of energy metabolism in hepatocytes with induced steatosis

Seitz, HK

Identification of cytochrome CYP2E1 as critical mediator of alcohol effects on steatotic hepatocytes

Sellge, G

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Sellmann, C

Einfluss von Arginin auf die Entstehung einer Western Style Diät-induzierten nicht alkoholbedingten Fettlebererkrankung (NAFLD): Untersuchungen im Mausmodell

Sens, C

Loss of Integrin-β1 in Hepatocytes Induces Liver Fibrosis

Serrano, BC

Biomarkers to predict the clinical outcome of hepatitis delta

Seufferlein, T

Aldosterone stimulates the non-genomic signaling pathway of the mineralocorticoid receptor in hepatic stellate cells

Sharif, Z

Damage and recovery of hepatic tissue of Mus musculus inhabited at metallurgical workshop

Sheikh, N

NAFLD linked hepatic iron stores and impact of fat reducing agents on males and females Rattus norveicus

Damage and recovery of hepatic tissue of Mus musculus inhabited at metallurgical workshop

Hepatoprotective Role of Nerium Oleander in Thioacetamide-Induced Chronic Inflammation

Gender linked counter effect of N. sativa seeds and P. ovata husks on fibrosis in NAFLD

Shen, Z

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Shevchenko, A

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Sicinski, P

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Siemers, E

Verbesserte Früherkennung der Leberbeteiligung bei Mukoviszidose

Singer, S

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Sini, M

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Sipos, B

Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma

Sitek, B

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Siveke, JT

Lineage fate of ductular reactions in liver injury and carcinogenesis

Skibbe, K

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Solbach, P

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Sollik, L

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Sonntag, R

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Sottile, J

Inflammatory cell infiltration in experimental liver fibrosis is affected by inhibition of fibronectin matrix assembly

Sowa, JP

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

Spannbauer, M

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

Spengler, U

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Spomer, L

Experimental validation of the predicted TGR5 binding mode model

Springfeld, C

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Sprinzl, M

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Sprinzl, MF

Array-based gene expression analysis of M1/M2-polarized macrophages during treatment with multi-kinase inhibitor Sorafenib

Stadler, D

Type III interferons induce cccDNA degradation similar to type I interferons in HBV-infected HepaRG cells

Staffer, S

Lysophosphatidylcholine (LPC) as central player for hepatic fat accumulation and inflammation: implication for the pathogenesis of NASH

Stallmach, A

A common polymorphism of tumor necrosis factor receptor-associated factor 6 (TRAF6) is associated with an increased risk for spontaneous bacterial peritonitis

Stangl, M

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Stanke, F

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Steffens, H

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Stempfl, T

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Stengel, S

A common polymorphism of tumor necrosis factor receptor-associated factor 6 (TRAF6) is associated with an increased risk for spontaneous bacterial peritonitis

Stenzinger, A

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Sterneck, M

Histopathology of chronic Hepatitis E

Sterzer, V

Specific Endoglin deletion in primary mouse hepatic stellate cells shows a modulation of TGF-b signaling pathways, aggravating liver fibrosis

Endoglin Knockdown inhibits Proliferation and NO Production in murine Sinusoidal Endothelial Cells in vitro

Stickel, F

Representation of human non-alcoholic fatty liver disease in murine models

Stockmann, M

Volumen-Funktionsplanung in der Leberchirurgie: Was kann man von der Kombination aus 3D- CT- Volumetrie mit dem LiMAx-Test erwarten?

Einfluss von akuten Komplikationen der Leberzirrhose auf die Lebensqualität von Patienten mit Leberzirrhose im Verlauf

Risikofaktoren für metabolische Störungen nach Lebertransplantation: Analyse von Daten nüchterner Patienten

Stokes, CS

Prevalence of hepatic steatosis in healthy health care workers as quantified by controlled attenuation parameter (CAP)

Improvement of Depressive Symptoms upon Correction of Vitamin D Deficiency in Women with Chronic Liver Disease

Strassburg, CP

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Use of beta-blockers is associated with improved 30 day survival in patients with spontaneous bacterial peritonitis

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Rolle des Mas Rezeptors in der Leberfibrose

Die Kostimulation mit CD40Ligand steigert die Immunantwort von Tumorantigen gepulsten humanen dendritischen Zellen gegenüber humanen hepatozellulären Karzinom- (HCC) und Cholangiozellulären Karzinom- (CCC) Zellen

Die Aktivität von cSRC bei der Leberfibrose

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Kombinationstherapie mit dem spezifischen Foxp3-Inhibitor P60 und einer Vakzinierung mit AdmAFP-transduzierten dendritischen Zellen im subkutanen und orthotopen murinen HCC-Tumormodell

Straub, B

Deficiency of calcium-independent phospholipase A2 beta in vivo causes systematic inflammation and hepatocellular carcinoma

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

Straub, BK

Phenprocoumon-induced liver injury

Streetz, K

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Streetz, KL

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Stremmel, W

Cardiac volume overload after long-term follow-up in TIPS patients

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Deficiency of calcium-independent phospholipase A2 beta in vivo causes systematic inflammation and hepatocellular carcinoma

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Identification and proteomic profiling of biliary exosomes

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

UDCA-LPE modulates different signaling pathways involved in hepatic fibrogenesis

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Stremmel, WR

Lysophosphatidylcholine (LPC) as central player for hepatic fat accumulation and inflammation: implication for the pathogenesis of NASH

Strnad, P

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Strucksberg, KH

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

Su, J

UDCA-LPE modulates different signaling pathways involved in hepatic fibrogenesis

Sunami, Y

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Sureau, C

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Susser, S

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

Sutor, D

Retinoic acid amplifies the FXR-dependent FGF19 gene expression in human enterocyte-like HT-29 cells by a bi-phasic mechanism

Sydor, S

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Visceral Adipose Tissue in NAFLD and NASH Patients is Closely Associated with Liver Injury

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

Syn, WK

Higher thyroid hormone levels are associated with better outcome in acute liver failure

Tacke, F

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Tan, S

Metformin Treatment Ameliorates Liver Injury Indicating Fatty Liver Polycystic Ovary Syndrome

Targett-Adams, P

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Tebrügge, I

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Teuber, G

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Teufel, A

Smad7 suppresses HCC development in a DEN induced mouse model

Tumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival

Representation of human non-alcoholic fatty liver disease in murine models

Tewes, B

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Thalhammer, J

Lineage fate of ductular reactions in liver injury and carcinogenesis

Thasler, W

Functional effects of monocarboxylate transporter 1 expression in activated hepatic stellate cells

Thasler, WE

Hepatic steatosis promotes growth and invasiveness of hepatocellular carcinoma cells in vitro and in vivo

Identification of cytochrome CYP2E1 as critical mediator of alcohol effects on steatotic hepatocytes

ERK and p38 activation are central mediators of irinotecan-induced steatohepatitis

The effect of extended transportation time on the quality of freshly isolated human liver cells

Thavamani, A

Serum Reponse Factor (SRF) is a transcriptional activator of Mouse Double Minute 4 (MDM4) in hepatocellular carcinoma

Thiel, C

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Neue Aspekte der Regulation des Lipidmetabolismus während der Entstehung von NAFDL

Thies, SJ

Rolle des Mas Rezeptors in der Leberfibrose

Thimme, R

Identification of CD8+ T-cell epitopes specific for hepatitis C virus genotype 4

Presence of naive-like HBV-specific CD8+ T cells in chronically infected patients despite ongoing viral replication

Dominance of HLA-B restricted virus-specific CD8+ T cell epitopes in chronic HBV infection

Thomas, M

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

Hepatic detoxification and anti-oxidative response in liver tissue with cholestasis: analysis of Nrf2 dependent gene expression

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Thonig, A

Die Hemmung der Glyoxalase-I durch Ethylpyruvat vermindert die LPS-induzierte Aktivierung von hepatischen Sternzellen

Thorgeirsson, S

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Thum, T

Increased serum levels of regenerative miRNAs in patients with spontaneous recovery from acute liver failure

Thurner, L

Progranulin autoantibodies and genetic variation in patients with cholangiocarcinoma

Tiegs, G

An additional heme oxygenase-1 knockout increases maturation of dendritic cells and liver inflammation in mdr2 knockout mice

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

CEACAM1 deficiency exacerbates acute liver injury in a mouse model of immune-mediated hepatitis

Tihaa, L

Platelet-derived growth factor-D intensifies fibrogenesis through upregulation of TIMP-1 expression and signalling through both platelet-derived growth factor receptors type α and β

Timm, J

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Tischendorf, J

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Tischendorf, S

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Trautwein, C

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Hohe Prävalenz von Leberwerterhöhungen in einer monozentrischen CED-Patienten Kohorte

Cyclin E1 expression level determines the anti-proliferative response of the pharmacological Cdk2 inhibitor Roscovitine in hepatoma cells and in the liver

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Pharmakologische oder genetische Intervention des CCL5/RANTES Signalweges im in vivo Modell einer chronischer Leberentzündung vermindert die Fibrogenese und Progression zum Hepatozellulären Karzinom

Specific Endoglin deletion in primary mouse hepatic stellate cells shows a modulation of TGF-b signaling pathways, aggravating liver fibrosis

Endoglin Knockdown inhibits Proliferation and NO Production in murine Sinusoidal Endothelial Cells in vitro

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

MIF shows profibrotic properties after MCD diet via NKT cell population

Trebicka, J

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Echokardiographische Speckle Tracking Analysen bei Patienten mit einer Leberzirrhose können das Überleben vorhersagen

Rolle des Mas Rezeptors in der Leberfibrose

Die Aktivität von cSRC bei der Leberfibrose

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Treckmann, J

Investigations on acetaminophen-induced liver injury using an ex-vivo perfusion model with human liver sections

Treckmann, JW

All-In-One: Advanced human parenchymal and non-parenchymal liver cell preparation

Triller, N

The interaction of the Hepatitis C Virus with intra-cellular signaling converts EGF into a potent inducer of the production of CXCR2-ligands by the infected host cell

Trippler, M

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Increased Lysyl oxidase-like 2 (LOXL2) gene expression accurately designates advanced liver fibrosis induced by the Hepatitis C Virus (HCV) regardless race, blood specimen or co-infection with the Human Immunodeficiency Virus (HIV)

Tschuschner, A

Regulation der Expression von MMPs und TIMPs nach Transplantation von mesenchymalen Stammzellen im Rattenmodell der chronisch-toxischen Leberschädigung

Tuma, S

Deficiency of calcium-independent phospholipase A2 beta in vivo causes systematic inflammation and hepatocellular carcinoma

Uerlings, R

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

Umgelter, A

Clinical immune monitoring: Impact of in vitro PBMC expansion on quantity and quality of HBV-specific CD4 and CD8 T cells

Unger, D

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Uschner, FE

Die Aktivität von cSRC bei der Leberfibrose

Effekte der akuten Gabe von Udenafil auf den Pfortaderdruck bei Ratten mit Leberzirrhose

Die Interaktion zwischen beta-Arrestin-2 und der AT1-Rezeptor abhängigen Signalkaskade in der Leberfibrose

Utpatel, K

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Valletta, D

Fibroblast growth factor 7 inhibits hepatic steatosis, inflammation and fibrosis in murine models of on non-alcoholic steatohepatitis

Functional effects of monocarboxylate transporter 1 expression in activated hepatic stellate cells

Increased expression of the Glucose-transporter GLUT1 during hepatic stellate cell activation promotes hepatic fibrosis

Van de Leur, E

NLRP3 inflammasome expression in cultured hepatocytes is regulated by nuclear factor-κB (NF-κB)

Platelet-derived growth factor-D intensifies fibrogenesis through upregulation of TIMP-1 expression and signalling through both platelet-derived growth factor receptors type α and β

van Roojen, N

Liver inflammation abrogates T cell mediated tolerance against particulate antigens induced by liver Kupffer cells

Vartak, A

Reconstruction and quantification of periportal bile ducts and Hering canal after bile duct ligation

Vasel, M

Inflammatory cell infiltration in experimental liver fibrosis is affected by inhibition of fibronectin matrix assembly

Venkata, PS

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Ventaka, SP

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Vetter, D

Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans

Vlaic, S

A quantitative metabolomic profiling and corresponding modeling approach of hepatocytes with activated Wnt/ß-Catenin signaling

Vogel, A

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Vogeser, M

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Vogt, A

Die Kostimulation mit CD40Ligand steigert die Immunantwort von Tumorantigen gepulsten humanen dendritischen Zellen gegenüber humanen hepatozellulären Karzinom- (HCC) und Cholangiozellulären Karzinom- (CCC) Zellen

Kombinationstherapie mit dem spezifischen Foxp3-Inhibitor P60 und einer Vakzinierung mit AdmAFP-transduzierten dendritischen Zellen im subkutanen und orthotopen murinen HCC-Tumormodell

Voigt, E

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Voigt, L

Assoziation von Autoantikörpern und Symptomen bei der Primär Biliären Zirrhose (PBC)

Vollbrecht, C

Comprehensive analysis of informative target disease relevant nuclear genes and the whole mitochondrial genome in hepatocellular carcinoma by Multiplex PCR and Ultra-Deep Sequencing

Vollmar, N

Metformin Treatment Ameliorates Liver Injury Indicating Fatty Liver Polycystic Ovary Syndrome

Volz, T

Human liver chimeric mice as a new model of Hepatitis E Virus infection and preclinical drug evaluation

Hepatitis Delta Virus can persist and propagate through human cell division both in vitro and in vivo

Vondran, FWR

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Human adult liver stem cells generated from patient samples

Vonnahme, M

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Vucur, M

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Vvedenskaya, O

Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Wagner, E

Development of delivery, targeting, and imaging strategies to improve oncolytic vesicular stomatitis virus therapy for hepatocellular carcinoma

Waidmann, O

25-hydroxyvitamin D deficiency is associated with infections and mortality in cirrhosis

Waisman, A

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Waldburger, N

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse

Waldow, K

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

Walker, A

Everolimus beeinflusst die HCV-Replikationsaktivität

Viral sequence analysis of the hepatitis B virus core protein reveals CD8 T cell epitopes under reproducible selection pressure

Walter, S

Endocytosis of the signal transducing receptor gp130 as mechanism to fine-tune IL-6 responses

Wan, S

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Wang, C

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes in mice

Wannhoff, A

Cardiac volume overload after long-term follow-up in TIPS patients

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Lysophosphatidylcholine (LPC) as central player for hepatic fat accumulation and inflammation: implication for the pathogenesis of NASH

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Warth, A

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Wasmuth, HE

MIF shows profibrotic properties after MCD diet via NKT cell population

Wasmuth, JC

Zusammenhang der zirkulierenden miRNA-122 Spiegel mit der portalen Hypertension bei HIV/HCV-positiven Patienten

Waurisch, C

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Waysczak, J

Kombinationstherapie mit dem spezifischen Foxp3-Inhibitor P60 und einer Vakzinierung mit AdmAFP-transduzierten dendritischen Zellen im subkutanen und orthotopen murinen HCC-Tumormodell

Weber, B

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Weber, F

Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection

Weber, SN

Comparative analysis of C5aR and C5L2 receptor deficiency in liver and kidney fibrosis

Wedemeyer, H

Kinetic of Hepatitis B core-related antigen (HBcrAg) levels in chronic hepatitis B during NUC therapy

Interruption of nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B – A new concept to achieve HBsAg decline?

Large scale biomarker profiling reveals distinct cytokine and chemokine signatures distinguishing different acute and chronic hepatitis virus infections

Modulation of HCV reinfection by fibroblast growth factor-2 and other non-interferon mediators

Serum biomarker profile can predict the outcome of acute HCV infection

Broad and cross-genotype-specific T cell responses during acute hepatitis E virus infection

Biomarkers to predict the clinical outcome of hepatitis delta

Clinical significance of drug-drug interactions during HCV therapy with sofosbuvir and simeprevir in comparison to first wave protease inhibitors

Delayed early HCV RNA response during IFN-free therapy with sofosbuvir in interferon-ineligible patients with advanced cirrhosis

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Histopathology of chronic Hepatitis E

The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu

Wegscheid, C

CEACAM1 deficiency exacerbates acute liver injury in a mouse model of immune-mediated hepatitis

Wei, W

Deficiency of calcium-independent phospholipase A2 beta in vivo causes systematic inflammation and hepatocellular carcinoma

Weichenhan, D

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Weichert, W

Methylome screen identifies epigenetically deregulated microRNAs in cholangiocarcinoma

Weiler, S

Cooperative function of YAP and TAZ in hepatocytes and hepatocarcinogenesis

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells

Weiler-Normann, C

Assoziation von Autoantikörpern und Symptomen bei der Primär Biliären Zirrhose (PBC)

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Weinmann, A

Array-based gene expression analysis of M1/M2-polarized macrophages during treatment with multi-kinase inhibitor Sorafenib

Einfluss metabolischer Faktoren auf die Prognose von Patienten mit fortgeschrittenem hepatozellulärem Karzinom unter Sorafenib Therapie

Weiskirchen, R

Inactivation of Cyclin E1 acts pro-apoptotic and anti-proliferative in primary hepatoma cells and protects from hepatocarcinogenesis in mice

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

NLRP3 inflammasome expression in cultured hepatocytes is regulated by nuclear factor-κB (NF-κB)

Platelet-derived growth factor-D intensifies fibrogenesis through upregulation of TIMP-1 expression and signalling through both platelet-derived growth factor receptors type α and β

Y-box-binding protein (YB-1) in murine models of hepatic and renal fibrosis

Lipocalin 2 (LCN2) in hepatic inflammation

Weiskirchen, S

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

Weiss, C

Cardiac volume overload after long-term follow-up in TIPS patients

Weiss, KH

Cardiac volume overload after long-term follow-up in TIPS patients

Late onset of disease is associated with poor outcome in patients with primary sclerosing cholangitis

Comprehensive profiling and predictive molecular marker identification for hepatocellular carcinoma

Hand-foot-syndrome is associated with improved survival in patients treated with sorafenib for hepatocellular carcinoma

Identification and proteomic profiling of biliary exosomes

A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis

Weiss, TS

Reduced HNF3b (FOXA2) levels in steatosis leads to diminished expression of anti-lipoapoptotic protein ALR

Hepatic detoxification and anti-oxidative response in liver tissue with cholestasis: analysis of Nrf2 dependent gene expression

Weller, H

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Welte, S

Nuclear CYLD expression plays a role in HCC therapy response in vitro

Weng, HL

Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines

Wenzel, JJ

HBsAg-specific humoral and cellular immune memory after hepatitis B booster vaccination in adolescents 10 – 15 years after immunization in infancy

Werner, J

The effect of extended transportation time on the quality of freshly isolated human liver cells

Westhaus, S

Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus

Oxidiertes Low Density Lipoprotein (oxLDL) – endogener HCV Eintritt Inhibitor und Prädiktor für SVR nach Interferon-basierter Therapie bei chronischer Hepatitis C

Wewering, F

Cytotoxicity of anisidine in hepatic cell lines

An in vitro system for the identification of DILI related signaling?

Wiechert, L

Role of RAGE and its ligands S100A8/A9 in hepatocellular carcinoma onset and development

Windler, E

Nicht-alkoholische Fettleberentzündung (NASH) – doch nur ein Problem der Energiezufuhr?

Winkler, J

Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

Winkler, S

Indirekte Wechselwirkungen zwischen HCC (Hep3B) und humanen mesenchymalen Stammzellen in vitro und in vivo

Wirth, T

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Wissel, S

Inhibition of canonical IKK/NF-kB signaling in Hepatitis B Virus surface antigen transgenic mice drastically increases HCC development due to dysregulated Unfolded Protein Response control

Witthöft, T

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Wittum, G

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

Wöbse, M

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Wöhler, C

Sp1 dependent transcriptional regulation of G-protein coupled bile acid receptor Gpbar-1: role of Krüppel like factor 5

Wohlleber, D

Differential regulation of TNF receptor signaling during viral infection of hepatocytes determines cell death

Wolf, D

Prädiktoren für splanchnische Thrombosen bei Patienten mit myeloproliferativen Neoplasien

Wolf, S

Hepatocytes secret a mediator pattern that induces macrophage phenotype with properties of wound healing type and regulatory macrophages

Wolf, T

Gene signatures define chromosomal instability (CIN) and poor survival in HCC patients

Wölfl, S

In vitro generation of 3-dimensional organoid liver structures using differentiatedhuman cells

Woller, N

Virotherapy overcomes tumor resistance to PD-1-immunotherapy by broad mutanome-directed T cell responses in mice

Wolter, F

Die HIV Infektion ist mit einer verminderten anti-HCV Aktivität von CD3+CD56+ NK-like T Zellen assoziiert

Wörns, MA

The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer

Bcl-3 reguliert die hepatische Lipo- und Gluconeogenese in einem murinen, hochkalorischen Fütterungsmodell der nicht-alkoholischen Fettlebererkrankung (NAFLD)

Einfluss metabolischer Faktoren auf die Prognose von Patienten mit fortgeschrittenem hepatozellulärem Karzinom unter Sorafenib Therapie

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Wraith, DC

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Wranke, A

Biomarkers to predict the clinical outcome of hepatitis delta

Wrba, F

Histopathology of chronic Hepatitis E

Wree, A

Visceral Adipose Tissue in NAFLD and NASH Patients is Closely Associated with Liver Injury

Wruck, C

Lack of hepatic keap-1 ameliorates steatosis through a negative LXR modulation without altering the innate immune response in a diet-induced model of nonalcoholic steato-hepatitis

Wunsch, E

Serum sterol levels indicate distorted cholesterol homeostasis in cirrhotic patients with primary biliary cirrhosis

Würger, T

Verstärkte hepatische Expression neuer MicroRNA bei ABCB4-/- Mäusen im Langzeitmodell

Wüstefeld, T

Integration of exome sequencing and in vivo RNAi screening identifies new cancer genes in hepatocellular carcinoma

Wüstenberg, A

Mechanisms of osteopontin-mediated effects on chronic hepatic inflammation and cancer

Xia, Y

Type III interferons induce cccDNA degradation similar to type I interferons in HBV-infected HepaRG cells

Yovchev, M

Engraftment and transdifferentiation of ectopic transplanted mature hepatocytes in a liver environment with ongoing biliary fibrosis

Yurdaydin, C

Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta

Zachoval, R

OPI ist zur Vorhersage der Mortalität und Morbidität nach Lebertransplantation geeigneter als BAR, MELD, D-MELD und DRI

Zanger, U

Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Mouse hepatic stellate cells are responsive to LPS and contribute to the acute phase response of hepatocytes

Hepatic detoxification and anti-oxidative response in liver tissue with cholestasis: analysis of Nrf2 dependent gene expression

Zanger, UM

MK2 mediates induction and sensing of Oncostatin M-induced intercellular signalling in the liver but is dispensable for negative feedback regulation via SOCS3

Zehnter, E

Renal impairment under triple therapy with boceprevir in German real-life: evidence for a pivotal role for peginterferon/ribavirin backbone, female gender and age elder than 50 years

Baseline gamma-GT levels within the normal range predict high virologic response rates in treatment-naïve patients undergoing boceprevir triple therapy for HCV genotype 1 (G1) infection

Baseline predictors of an early virologic response (EVR) in previously untreated patients undergoing boceprevir (BOC) triple therapy for HCV genotype 1 infection in German real-life

Current clinical evaluation of the patient with HCV genotype 1 infection before antiviral treatment in German routine clinical practice

Female gender, age elder than 50 years and a reduced glomerular filtration rate (eGFR) at baseline strongly predict the frequency of anemia in patients undergoing boceprevir triple therapy in German real-life

Treatment of previously untreated patients with chronic HCV genotype 1 infection with boceprevir in German real-life: high end of treatment response of 95% in patients with early virologic response

Zellmer, S

Cytotoxicity of anisidine in hepatic cell lines

An in vitro system for the identification of DILI related signaling?

Zender, L

Integration of exome sequencing and in vivo RNAi screening identifies new cancer genes in hepatocellular carcinoma

Zenouzi, R

Budesonide in autoimmune liver disease: treatment response in a large real life cohort

Duration of remission and interpretation of biochemical markers within the normal range help to identify patients with high chance for sustained remission after treatment withdrawal in autoimmune hepatitis

Zeuzem, S

Untersuchung von Resistenzmutationen innerhalb der NS3 Protease zur Vorhersage des Therapieausgangs der HCV Triple-Therapie

25-hydroxyvitamin D deficiency is associated with infections and mortality in cirrhosis

Zimmer, V

Progranulin autoantibodies and genetic variation in patients with cholangiocarcinoma

Zimmermann, A

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in trace metal imaging of experimental and clinical metal disorders

Zimmermann, T

Relevance of organic cation transporter OCT1 (SLC22A1) in Diethylnitrosamine-initiated and Phenobarbital-promoted hepatocellular carcinoma in OCT3- knockout mice

Zipprich, A

Die Hemmung der Glyoxalase-I durch Ethylpyruvat vermindert die LPS-induzierte Aktivierung von hepatischen Sternzellen

Regulation der Expression von MMPs und TIMPs nach Transplantation von mesenchymalen Stammzellen im Rattenmodell der chronisch-toxischen Leberschädigung

Prevalence of hyperdynamic circulation in cirrhosis: lack of association to presence and severity of ascites

Zitzmann, A

HBsAg-specific humoral and cellular immune memory after hepatitis B booster vaccination in adolescents 10 – 15 years after immunization in infancy

Zwank, C

Dysregulierte Interaktion zwischen CD4+ T Zellen und NK Zellen in der HIV/HCV Koinfektion

Zyriax, B

Nicht-alkoholische Fettleberentzündung (NASH) – doch nur ein Problem der Energiezufuhr?