Abstracts (HTML) List of Authors

Haas, U

LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses
Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Haberl, EM

Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration

Haderer, M

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Hagel, C

Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose

Haifeng, X

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Hall, RA

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Haller, D

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Hamesch, K

In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Hammad, S

Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

Hampe, J

The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of zonation in end stage liver disease revealed by in situ omics
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis

Han, M

Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo

Hanenberg, H

A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)

Hardtke, S

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis

Harris, R

Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Harten, M von

Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis

Hartl, J

Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose

Hartmann, D

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Hartmann, H

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics

Hartmann, M

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Hartmann, N

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Hartwig, V

Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver

Hassan, R

A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Hatting, M

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Haupts, A

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines

Häussinger, D

Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression
Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet
Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3
Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Haybaeck, J

Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis

Healy, M

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Heeren, J

LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Heide, D

Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)

Heikenwälder, M

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Heilmann-Heimbach, S

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer

Heim, K

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Heimes, CV

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Heine, K

Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses

Heinold, A

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Heinrich, F

The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis
The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells

Heinrich, S

Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Steatosis and associated proteins in hepatocellular adenoma
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma

Heinrichs, D

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Heinsen, FA

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Heintz, L

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Heinzow, H

An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score

Hellerbrand, C

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis
The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma
Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma
Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma

Helm, F

Delivery of Copper-chelating Trientine (TETA) to the central nervous system

Hempel, M

Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Hendricks, L

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Hengstler, JG

Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients

Hennings, J

Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD

Hensel, N

Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis

Herkel, J

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis

Hermanns, HM

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M

Hermanussen, L

Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction

Herpel, E

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Herrera Gonzalez, BM

Characterization of the liver phenotype of the BMP-9 knock-out mouse

Herrmann, A

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics

Heyne, R

Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Hinrichsen, H

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Hippchen, T

The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis
Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort

Hochrath, K

Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene

Hoffmann, D

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Hoffmann, K

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis

Hoffmeister, C

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Hofmann, M

Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma

Hofmann, U

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
A mouse model of chronic liver disease progression and acute-on-chronic liver failure

Hofmann, WP

Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study

Hohenester, S

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Höhme, S

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

Holland, C

Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Holz, R

Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study

Holzer, K

Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1

Hooiveld, GJ

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Hoppmann, H

TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis

Horner, R

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Horst, AK

Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation

Horst, D

Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model

Hou, J

ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis

Howe, T

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Hsu, MJ

Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids

Hu, X

MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment

Huang, J

B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Hübbers, A

Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells

Huber, M

Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen

Huber, S

Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice

Huber, Y

Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)

Hueser, N

Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival

Hüser, N

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice