Abstracts (HTML) List of Authors

Kaderali, L

Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma

Kah, J

T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection

Kahraman, A

Intravenous therapy of hepatic encephalopathy with L-ornithine l-aspartate (Lola) is safe and very effective
Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients
Characteristics and outcome of 544 patients with autoimmune hepatitis (AIH) – a single centre experience
Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Kaiser, K

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Kalkhof, S

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Kallin, N

Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Kamlage, B

Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease

Kanitz, V

Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell

Kantowski, M

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

Karagoz, E

Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice

Karatayli, E

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Karatayli, SC

Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model

Karimzadeh, H

Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
HDVdb: Hepatitis D virus database
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Karsdal, M

Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis

Kasper, P

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany

Kather, JN

miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis

Kattler, K

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics

Kauer, L

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Kaufmann, B

Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice

Keitel, V

Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration

Kellerer, M

Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation

Kemming, J

Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Kemper, T

Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes

Kern, L

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Kersting, S

Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease

Khajeh, E

Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy

Kickuth, R

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Kiessling, F

Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing

Kim, P

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Kimer, N

The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis

Kiraithe, M

Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV

Kircher, M

Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)

Kirchner, M

Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma

Klausen, G

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Kleeschulte, S

Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet

Klein, I

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Klein, R

Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)

Klingmüller, U

Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers

Klinker, H

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Klopp, A

Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells

Klöters-Plachky, P

Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis

Klotz, S

Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling

Kluge, M

Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?

Kluwe, J

LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis

Knight, A

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Knolle, PA

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Identification of the unique functional phenotype of iMATE-defining monocytes that drive hepatic T cell proliferation
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver

Ko, C

Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection

Koch, A

Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes

Koch, M

Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening

Koczulla, R

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert

Kohlhepp, M

Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression

Köhncke, J

Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice

Kohnke-Ertel, B

A targeted screen to identify relevant oncogenes in RAS activated liver cancer

Kolbe, E

Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation

König, V

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression

Kontoyiannis, D

The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis

Kook, L

Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection

Koop, A

LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis

Korte, I

Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Koschny, R

Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival

Köse, N

Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis

Kotsiliti, E

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer

Krabbe, V

Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome

Kraft, ARM

Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B

Krag, A

Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications

Krämer, B

Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation

Kratochvil, I

Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Krawczak, M

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics

Krawczyk, M

The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Kremer, AE

Lysophosphatidic acid activates peripheral glial cells
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Kriegsmann, M

RSPO2 gene rearrangement – a new cancer driver in the liver

Kristiansen, G

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Kriz, M

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Kroy, DC

Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression

Krstic, T

The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice

Kubes, P

Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer

Kubicka, S

Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Kücükoglu, Ö

Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten

Kudlich, T

A simple clinical score to predict survival in patients with hepatocellular carcinoma

Kueppers, A

Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Kuhn, M

High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)

Kühn, H

Lysophosphatidic acid activates peripheral glial cells

Kühne, H

Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis

Kühnel, F

Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model

Kummer, U

Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells

Kunst, C

Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis

Kunzmann, L

Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)

Kurz, S

Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver

Kütting, F

No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany