Introduction
Gastroparesis is a chronic functional disorder characterized by delayed gastric emptying,
in the absence of mechanical obstruction, and a variety of other symptoms [1]. It has a high prevalence in the United States (approximately 3 %). Common etiologies
of gastroparesis include diabetes and surgery. The major symptoms include nausea,
vomiting, postprandial fullness, and early satiety, with impaired quality of life.
In patients with diabetes, gastroparesis could be responsible either for uncontrolled
diabetes mellitus and/or postprandial hypoglycemia as a consequence of a significant
glucose imbalance.
Delayed gastric emptying has to be confirmed by scintigraphy and is defined as the
percentage of the remaining radioisotope at 2 hours (%H2) > 60 % and at 4 h (%H4)
> 10 % [2]. The treatment for gastroparesis includes a specific diet (frequent small meals
with low fat and fiber content) and prokinetics drugs [3]
[4]
[5]. However, some of these drugs are associated with dangerous side effects (e. g.
cardiac arrhythmia); tachyphylaxis can also occur, making them ineffective. There
is currently no validated therapeutic alternative if these treatments fail.
The pathophysiology of gastroparesis is complex and involves antral, fundic or pyloric
motor dysfunction. Indeed, pylorospasm has been reported in some patients [6], and a high fasting pyloric tone has been found in almost 50 % of cases. Fasting
compliance is low in patients with gastroparesis and negatively correlated with gastric
emptying [7]. The procedures used to treat pyloric dysfunction, including botulinum toxin injection
[8], surgical pyloroplasty [9], pyloric dilation [10], and transpyloric stenting [11]
[12], have produced promising results in open studies but not in randomized studies [13]
[14]. A new and simple procedure for selecting gastroparetic patients who are suitable
for an endoscopic treatment that targets pyloric dysfunction is the endoscopic functional
luminal imaging probe (Endoflip; Crospon, Galway, Ireland) [15]
[16].
Among the possible endoscopic procedures, four recent small retrospective studies
and one case series ([Table 1]) have suggested the efficacy of peroral pyloromyotomy/gastric peroral endoscopic
myotomy (G-POEM) for treating severe refractory gastroparesis [17]
[18]
[19]
[20]
[21]
[22]
[23]
[24]. However, the lack of a systematic evaluation of gastric emptying, the heterogeneity
of the patients and follow-up procedures, the retrospective experimental design, and
the lack of consistent procedures for assessing pyloric function can only be addressed
by a well-designed prospective study. The development of a new therapeutic procedure
could represent an important step forward for affected patients.
Table 1
Results of previously published series on peroral endoscopic pyloromyotomy in refractory
gastroparesis.
|
Design
|
N
|
Technical success, %
|
Clinical success, % (n/N)
|
GES improvement, % (n/N)
|
Adverse events, n
|
Follow-up, months
|
|
Shlomovitz 2015 [17]
|
Retrospective
|
7
|
100
|
86 (6/7)
|
80 (4/5)
|
1 bleeding
|
6.5
|
|
Khashab 2017 [21]
|
Retrospective
|
30
|
100
|
86 (26/30)
|
78 (14/17)
|
1 capnoperitoneum
1 ulcer
|
5.5
|
|
Gonzalez 2017 [33]
|
Retrospective
|
29
|
100
|
75 (M3)
69 (M6)
|
87 (20/23)
|
5 pneumoperitoneum
2 bleeding
1 Abscess
1 stricture
|
10
|
|
Dacha 2017 [22]
|
Retrospective
|
16
|
100
|
81 (M6)
|
100 (12/12)
|
0
|
6
|
|
Rodriguez 2017 [19]
|
Case series
|
47
|
100
|
Significant improvement
|
Significant improvement
|
0
|
3
|
GES, gastric emptying scintigraphy; M, month
The aim of the current study was to evaluate the feasibility, safety, and efficacy
of G-POEM in patients with refractory gastroparesis.
Methods
Study participants
We performed a prospective study to evaluate the technical success, safety, and efficacy
of G-POEM for treating refractory gastroparesis at Limoges University Hospital from
April 2016 to June 2017. This study was funded by the Protocole Hospitalier de Recherche
Clinique Interrégional and approved by the institutional review board (NCT02779920).
Gastroparesis was defined by confirming the association of symptoms with delayed gastric
emptying at 4 hours (%H4 retention > 10 %) using gastric scintigraphy.
All patients included in this study were > 18 years old and had moderate-to-severe
refractory gastroparesis, defined as persistent symptoms and reduced quality of life
despite 6 months of continuous treatment, including at least two of the three drugs
that are available in France for treating gastroparesis (erythromycin, a motilin receptor
agonist; domperidone or metoclopramide, dopamine receptor antagonists).
Gastroparesis was considered moderate to severe in cases of a Gastroparesis Cardinal
Symptom Index (GCSI) score > 2.6, refractory vomiting or a chronic diabetes imbalance
with recurrent postprandial hypoglycemia. All patients provided written informed consent.
Patients were excluded if they had a medical contraindication for gastroscopy or general
anesthesia, or were taking anticoagulants or antiplatelet agents, or had a history
of gastric surgery or a hemostatic disorder.
Study design
All study participants were treated using G-POEM, according to a procedure published
previously, with a submucosal tunnel performed along the greater curvature [21]
[22] ([Fig. 1, ]
[Video 1]). G-POEM was performed under general anesthesia with patients in the supine position
and intubated. Immediately prior to the G-POEM procedure, pyloric function was evaluated
using the Endoflip device by inflating the sleeve with 40 mL and 50 mL of liquid.
Intubation was performed without curarization when possible. If curarization was necessary,
celocurine was used because of its short half-life, and we included a delay of 20
minutes to confirm normal muscular neurotransmission using a TOF-Watch SX accelerometer
(Organon Ltd., Dublin, Ireland) before taking the Endoflip measurements.
Fig. 1 Description of the procedure. a Identification of the pylorus. b Mucosal incision. c Submucosal tunneling. d, e Checking the direction of the tunnel. f, g Identification of the pyloric ring. h,i Pyloromyotomy. j End of the myotomy (pink serosa). k, l Closing the tunnel entry.
Video 1 Peroral endoscopic pyloromyotomy.
The Endoflip probe was passed along a high definition gastroscope, with a suture attached
at the distal part of the probe, and grasped with biopsy forceps to help the probe
through the pyloric channel under endoscopic visualization. Diameter, cross-sectional
area, pressure, distensibility, and compliance were measured or calculated by software
at each balloon distension point for a minimum of 5 seconds.
G-POEM procedure
A high definition gastroscope with a transparent hood and carbon dioxide insufflation
were used for the procedure. A glycerol solution was injected 4 – 5 cm from the pylorus,
and a longitudinal mucosal incision was made using a T-type HybridKnife (Erbe Elektromedizin
GmbH, Tübingen, Germany) and a VIO 200 D using Endocut I current (Erbe Elektromedizin
GmbH). A submucosal tunnel dissection was performed using a swift coagulation current.
The scope was regularly withdrawn from the tunnel to check the tunneling direction.
The submucosal vessels were coagulated using the HybridKnife or Coagrasper coagulation
forceps (Olympus, Tokyo, Japan). After separation of the pyloric muscle arch, a myotomy
was performed using a HookKnife (Olympus), dissecting from the duodenal to the gastric
side with a safe traction technique. The myotomy was extended 1 – 2 cm along the antral
muscularis propria until thin “pink” serosa was visible. The tunnel entry was then
closed with hemoclips using the “zip” technique. The first hemoclip was placed on
the distal part of the longitudinal incision. This first clip brought the edges of
the incision closer. Then, the longitudinal incision was progressively closed using
hemoclips, which caught the edges of the mucosal incision from the distal to the proximal
part. If a perforation occurred, a nasogastric tube was positioned following the procedure.
Patients fasted on the day of the procedure; a liquid diet was provided the following
day and a normal diet was resumed 2 days after the procedure. Patients were discharged
2 – 3 days after G-POEM. The evaluation of symptoms using GCSI, and quality of life
using the Patient Assessment of Upper Gastrointestinal Disorders – Quality of Life
(PAGI-QoL) scale and the Gastrointestinal Quality of Life Index (GIQLI), were performed
the day before the G-POEM procedure, and at 1 and 3 months after the procedure. Postoperative
Endoflip measurements and gastric scintigraphy were performed 3 months after G-POEM
to evaluate gastric emptying.
Study end points
The primary end point of the study was technical success, defined as the total number
of successful procedures relative to the number initiated. Procedural success was
defined as identifying the pyloric ring after submucosal tunneling and completing
the pyloromyotomy.
The secondary end points were as follows.
-
The safety profile of the G-POEM procedure: all adverse events (i. e. cause, severity,
seriousness according to ICH E2A criteria and outcome). Adverse events were considered
severe if a life-threatening condition, hospitalization, significant or sustained
disability or any medically serious event was involved.
-
Clinical success: decrease of at least 0.75 on the GCSI.
-
An evaluation of the efficacy of G-POEM in terms of:
-
gastric emptying (scintigraphy at 3 months)
-
clinical symptoms (GCSI before and at 1 and 3 months after G-POEM); symptoms were
evaluated using the GCSI, which uses a 6-point Likert scale ranging from none (0)
to very severe (5). Based on the GCSI development data, a total GCSI score > 2.6 was
used to define moderate disease, and a total GCSI score > 3 was used to define severe
disease
-
abdominal pain and abdominal discomfort were evaluated using the same 6-point Likert
scale, ranging from none (0) to very severe (5)
-
quality of life (PAGI-QoL and GIQLI before, and at 1 and 3 months after G-POEM)
-
Endoflip results.
-
An evaluation of pyloric distensibility before and 3 months after G-POEM.
Statistical analysis
Because this was a pilot study, no sample size calculation was performed. The study
database was created using Oracle-based CLINSIGHT software (www.ennov.com) and the CS-DESIGNER module. The statistical analysis was performed using SAS software
(ver. 9.3; SAS Institute, Cary, North Carolina, USA), and a P value of < 0.05 was considered significant.
The differences between pyloric compliance and distension, gastric emptying half-time,
and gastric retention at 2 and 4 hours, and the GCSI, GIQLI, and PAGI-QoL scores were
analyzed using the Wilcoxon signed-rank test. Receiver operating characteristics curves
were constructed using MedCalc statistical software (https://www.medcalc.org/) to estimate the ability of distensibility and compliance of the pylorus measured
by Endoflip to predict the success of the G-POEM procedure.
All adverse events were coded based on verbatim notes of the investigator using the
MedDRA dictionary v20.0.
Results
Study population
A total of 110 patients were evaluated for suspected severe and refractory gastroparesis,
and 20 were included between April 2016 and June 2017 ( [Fig.2]). In total, 10 patients had diabetic gastroparesis, and 10 had nondiabetic gastroparesis.
In this latter group, four patients (20 %) had idiopathic gastroparesis, three (15 %)
had gastroparesis secondary to Sjögren’s syndrome, one (5 %) had postsurgical gastroparesis,
one (5 %) had gastroparesis secondary to Parkinson’s disease, and one (5 %) had gastroparesis
secondary to systemic sclerosis. The median body mass index was 24.96 kg/m2. A total of 13 patients (65 %) had a dedicated nutritional follow-up because of their
gastroparesis. Despite this specialized monitoring, 35 % (n = 7) and 15 % (n = 3)
of patients had lost at least 5 % and 10 % of their weight, respectively, in the preceding
6 months. One patient required enteral nutrition because of clinical malnutrition.
Fig. 2 Patient flow through the study. GCSI, Gastroparesis Cardinal Symptom Index; GES,
gastric emptying scintigraphy; G-POEM, peroral endoscopic pyloromyotomy.
Overall, 16 patients (80 %) had a GCSI > 2.6, 15 (75 %) had a GCSI > 3, and 8 (40 %)
had a GCSI > 4. Of the four patients with a GCSI < 2.6, two diabetic patients had
daily refractory vomiting, one diabetic patient had recurrent severe postprandial
hypoglycemia due to severe gastric emptying, and one patient suffered from Parkinson’s
disease with failure of L-DOPA therapy, which was suspected to be linked to her confirmed
severe delayed gastric emptying.
Median abdominal pain and median abdominal discomfort were 4.0 and 4.5, respectively.
Two patients (10 %) had undergone previous botulinum toxin injection but had not responded
to treatment, and no patients were subjected to gastric electric stimulation because
in France there is no reimbursement for this two-therapy strategy. All patients had
delayed gastric emptying with a %H4 median of 57 %. At inclusion, the median total
GCSI was 3.5 (interquartile range[IQR] 2.9 – 4.3), the median PAGI-QoL score was 3.0
(IQR 2.2 – 3.4), and the median GIQLI was 63.0 (IQR 55.0 – 76.0).
Data on pyloric function, measured using the Endoflip probe prior to the G-POEM procedure,
were as follows (median; IQR):
-
40 mL distension volume: diameter 13.9 mm (12.4 – 15.4), pressure 12.7 mmHg (11.2 – 17.8),
compliance 335.9 mm3/mmHg (271.0 – 419.0), area 152.5 mm2 (120.0 – 184.5), distensibility 11.7 mm2/mmHg (8.3 – 15.8).
-
50 mL distension volume: diameter 17.3 mm (15.0 – 18.2), pressure 28.9 mmHg (24.0 – 32.1),
compliance 235.6 mm3/mmHg (190.0 – 321.0), area 234.5 mm2 (177.5 – 258.0), distensibility 8.1 mm2/mmHg (5.7 – 11.2).
Primary end point
The technical success of the G-POEM procedure was 100 %.
The median duration of the procedure was 56.5 minutes (IQR 48.5 – 67.0). The median
durations of submucosal tunneling and myotomy were 23.0 minutes (IQR 20.0 – 28.5)
and 17.5 minutes (IQR 15.5 – 21.0), respectively. The mean duration of inpatient hospitalization
for the procedure was 3.75 days.
Secondary end points
Clinical efficacy
We observed a significant improvement in the GCSI ( [Fig. 3]). The median preoperative GCSI was 3.5, and this improved to 1.8 at 1 month (P < 0.001) and 1.3 at 3 months (P < 0.001). All GCSI subscales (i. e. nausea, satiety, and bloating) improved significantly
([Fig. 3]). About 90 % of patients showed a clinically significant improvement, defined as
a decrease in the GCSI of at least 0.75. Individual responses are shown in [Fig. 4]. The median improvement in GCSI was 65 %, while seven patients (35 %) showed a > 75 %
improvement in their symptoms
Fig. 3 Clinical results. GCSI, Gastroparesis Cardinal Symptom Index; M, month.
Fig. 4 Individual changes in Gastroparesis Cardinal Symptom Index scores.
All individual symptoms, with the exception of retching, were significantly improved
by G-POEM ([Fig. 5]).
Fig. 5 Changes in individual symptoms of the Gastroparesis Cardinal Symptom Index. Median
values are shown. M, month
Quality of life evaluation
Patients treated using G-POEM reported significant improvements in their quality of
life ([Fig. 6]). The median preoperative PAGI-QoL and GIQLI scores of 3 and 63 improved to 4.1
and 97, respectively at 3 months (P < 0.001).
Fig. 6 Quality of life evaluation. Median values are shown. M, month; PAGI-QOL, Patient
Assessment of Upper Gastrointestinal Disorders – Quality of Life; GIQLI, Gastrointestinal
Quality of Life Index.
Efficacy in gastric emptying
All scintigraphic parameters (half-life [T½], %H2, and %H4) improved significantly
following G-POEM. The median T½ decreased from 345 minutes (IQR 130.5 – 374.5) to
100 minutes (IQR 73.5 – 256) at 3 months (P < 0.001). The %H2 decreased from 81.5 % (IQR 68 – 91.5) to 56.0 % (IQR 36.5 – 79.0;
P = 0.001), and the %H4 decreased from 57.5 % (IQR 26.5 – 71.5) to 15.0 % (IQR 8.0 – 55.0)
at 3 months (P = 0.003). The individual %H4 values before and after the G-POEM procedure are shown
in [Fig. 7]. Six patients (30 %) had normal %H4 values.
Fig. 7 Gastric emptying scintigraphy (%H4) before and after peroral endoscopic pyloromyotomy.
a Overall change. b Individual patients. M, month.
Evaluation of pyloric function before and after G-POEM
Prior to G-POEM, no correlation was found between the Endoflip results and the GCSI
scores or the results of gastric emptying, and no difference in pyloric function was
observed between patients with and those without diabetes. At 3 months, the pyloric
pressure measured with 50 mL of distension was significantly better in patients with
diabetes than in those without (31.6 vs. 23.6 mmHg; P = 0.03).
G-POEM was associated with a significant increase in both pyloric diameter (+ 1.6 mm
in mean; P = 0.01), especially in patients with diabetes (+ 2.4 mm in mean; P = 0.004), and distensibility index ( + 2 mm2/mmHg in mean; P = 0.04), also especially in diabetic patients (+ 4 mm2/mmHg in mean; P = 0.03).
Evaluation of clinical efficacy according to pyloric function
Clinical efficacy was defined by improvements in the GCSI > 0.75. A pyloric 50-mL
distensibility index < 9.2 mm2/mmHg was associated with a clinical efficacy of G-POEM with 100 % specificity and
72.2 % sensitivity (P = 0.04; 95 % confidence interval 0.51 – 0.94; area under the curve 0.72). The positive
predictive value of this threshold was 100 %, but the negative predictive value was
only 28.5 %.
Evaluation of the safety profile
A total of 28 adverse events, including six serious adverse events, occurred in 16
patients ([Table 2]). A total of 20 adverse events were related to G-POEM, including one serious adverse
event. This serious adverse event was severe abdominal pain in a patient who had a
perforation. Despite a normal blood test and a computed tomography scan, we decided
to perform an explorative laparoscopy because the pain remained, even after treatment
with strong opioid analgesics. The pain resolved a few hours after laparoscopy.
Table 2
Safety analysis.
|
Adverse events[1]
|
Number of adverse events
|
Related to G-POEM
|
Severity
|
|
Serious adverse events[2]
|
|
Procedural pain
|
1
|
Related
|
Severe
|
|
Fecaloma
|
1
|
Not related
|
Moderate
|
|
Urinary retention
|
2
|
Not related
|
Mild
|
|
Sciatica
|
1
|
Not related
|
Severe
|
|
Subileus
|
1
|
Not related
|
Severe
|
|
Nonserious adverse events
|
|
Procedural pain
|
8
|
Related
|
Mild (n = 6)
Moderate (n = 2)
|
|
Procedural hemorrhage
|
7
|
Related
|
Mild
|
|
Gastric perforation
|
3
|
Related
|
Mild
|
|
Epistaxis
|
1
|
Related
|
Mild
|
|
Dyspepsia
|
1
|
Not related
|
Moderate
|
|
Ligament sprain
|
1
|
Not related
|
Mild
|
|
Wrist fracture
|
1
|
Not related
|
Mild
|
G-POEM, peroral endoscopic pyloromyotomy.
1 Preferred terms from the MedDRA dictionary (v20.0).
2 According to E2A criteria.
The other G-POEM-related adverse events included three cases of perforation; exsufflation
of the capnoperitoneum was unnecessary, but a nasogastric tube was placed and antibiotics
(amoxicillin and clavulanate) were administered for 5 days. Seven cases of per-procedure
bleeding occurred but no transfusion was necessary; bleeding was managed using coagulation
forceps and, in one case, using the plate of the T-type HybridKnife. No post-procedural
bleeding occurred. There were eight cases of post-procedural abdominal pain at Day
1, which was managed easily by proton pump inhibitors and paracetamol. There was also
one case of epistaxis. These adverse events affected 13 patients and all resolved
without sequelae.
Discussion
This is the first prospective trial evaluating G-POEM as a treatment for refractory
gastroparesis with a concomitant assessment of pyloric function by the Endoflip device.
It confirms the feasibility of the procedure when performed by endoscopists who are
experts in endoscopic submucosal dissection.
Identifying the pyloric ring was straightforward in the current study, in contrast
to a recent American study that used a radiopaque clip to locate the pylorus before
beginning the procedure [18]. However, our team had previously practiced the procedure on pigs in vivo, and our
assessments of the pathology of the pyloric muscle agreed with our endoscopic observations
in every case [25].
The procedure was not lengthy (median duration 56.5 minutes), and the safety profile
was very good, although three perforations occurred. In all cases, the perforations
were “voluntary” because, in cases of doubt, we preferred to be sure that complete
myotomy had been achieved in order to ensure effectiveness of the procedure. Per-procedure
bleeding is generally not considered an adverse event in submucosal endoscopy, but
the independent team monitoring adverse events preferred to mention them to ensure
that the report was comprehensive.
As in previous retrospective studies, we observed both significant clinical and scintigraphic
improvements in our patients. The median improvement in the GCSI was 65 %, and 90 %
of patients reported a clinical improvement, defined as an improvement in the GCSI
of at least 0.75. We chose > 0.75 reduction of GCSI as the cutoff for clinical success
because it is the threshold that has been determined and validated in the international
validation study of the GCSI. Several authors have defined clinical success as a reduction
in GCSI of > 1 because they found this threshold to be more clinically relevant. When
we used this threshold, the clinical success rate was 75 %, which is still impressive
for this disease. The use of this threshold is one of the strengths of our study because
other studies on G-POEM only defined clinical improvement as a decrease in the GCSI
without a cutoff for improvement.
The clinical and quality-of-life improvements observed in this study are based on
scales validated by recognized international authorities (i. e. the GCSI, PAGI-QoL,
and GIQLI). However, the study was not randomized or blinded. Many of the patients
had been waiting for the procedure for several months and their refractory gastroparesis
had been monitored over an extended period. Therefore, a placebo effect may have played
a part in the clinical evaluations.
Nonetheless, the scintigraphic results are impressive. The median %H4 retention rate
decreased from 57.5 % to 15.0 % at 3 months. At variance with the clinical evaluations,
the scintigraphic findings are objective and the lack of randomization and blinding
does not affect these results. Our results showed that G-POEM significantly improved
gastric emptying. However, clinical improvement and acceleration of gastric emptying
is often unrelated [26]
[27]
[28]. Our results are promising for many patients whose quality of life is affected by
refractory gastroparesis.
Other endoscopic procedures (e. g. botulinum injection, transpyloric stenting, and
pyloric dilation) and nonendoscopic procedures (e. g. gastric electric stimulation
[29]
[30]
[31]
[32]) have shown promising results in open studies but not in blinded randomized trials.
One possible reason for unsuccessful procedures might be the selection of patients
entering the trials. Indeed, it can be difficult to identify those patients who will
benefit most from a particular treatment, and it is not clear which patients benefited
from treatment that targets pyloric function. Gastroparesis is a complex disease that
is difficult to treat because of various etiologies and a lack of tools to evaluate
gastric physiology. Endoflip is a promising method for the evaluation of pyloric function
and the identification of gastroparetic patients with a pyloric dysfunction who could
be the best candidates for endoscopic pyloric therapy. We identified a distensibility
threshold of 9.2 mm2/mmHg before the G-POEM procedure that predicted a clinical response with 100 % specificity
and 72.2 % sensitivity. The positive predictive value of this threshold was 100 %,
meaning that all patients with a distensibility under 9.2 mm2/mmHg reported a clinical success, defined as an improvement of GCSI of at least 0.75. Unfortunately,
the negative predictive value was quite low (28.5 %), meaning that in our study, Endoflip
could only select patients that will respond to G-POEM but not patients who will fail
to respond to the procedure. More well-designed studies using Endoflip are needed
to confirm the potential of this tool in this indication.
Gourcerol et al. reported that a threshold of 10 mm2/mmHg predicts the efficiency of pyloric dilation [7]. In that study, using the 90th percentile, the cutoff normality was 10 mm2/mmHg in 27 healthy volunteers. They also found a lower pyloric distensibility in
gastroparetic patients compared with healthy volunteers (16.2 vs. 25.2 mm2/mmHg; P < 0.05) with the Endoflip inflated to 40 mL. In our study, 45 % of patients had a
40 mL distensibility that was lower than the threshold of 10 mm2/mmHg. Moreover, the mean distensibility of 40 mL in our study was quite low at 12.4 mm2/mmHg, lower than the 16.9 mm2 /mmHg in the study by Gourcerol.
Endoflip can also be used just after the procedure to check the adequacy of the myotomy,
as it has been for POEM in patients with achalasia.
However, this conclusion must be treated with caution. We did not have enough patients
to confirm our threshold value, so larger studies investigating G-POEM with a systematic
preoperative evaluation of pyloric function with Endoflip are required. Antroduodenal
manometry may also be used to identify suitable patients; however, only one facility
in France provides this service, and it is difficult to perform.
Patients who respond to pyloric toxin injections could be a good target for G-POEM
because the therapeutic mode of action is theoretically similar. However, in our study,
only two patients had prior botulinum toxin injections. Indeed, in France, pylorus
botulinum toxin injections for refractory gastroparesis are not reimbursed, as there
is a lack of controlled trial data. It has been proposed to be a compassionate treatment.
Our hospital accepts financial support for this therapy only in exceptional cases
after validation by a financial committee.
Because there were few patients in this study who failed to show clinical and scintigraphic
improvement, we were unable to identify risk factors for the lack of a response to
G-POEM. Gonzalez et al. [33] showed in univariate analyses that both diabetic and female patients have nonresponse
risk factors at 6 months. Our results do not suggest that diabetes reduces the likelihood
of treatment success; however, our nondiabetic patient group was heterogeneous and
very different from the nondiabetic groups of previous series, which consisted mainly
of patients with idiopathic and postsurgical gastroparesis. Only one patient in our
study had postsurgical gastroparesis after antireflux surgery, but this condition
may be one of the most suitable etiologies for G-POEM because pyloric dysfunction
may be linked to a surgical lesion on the vagus nerve, occurring during confection
of the wrap; the vagus nerve injury increases pyloric tone.
The weaknesses of this trial are the lack of a sham procedure with which to compare
clinical improvement, and the short follow-up, which was only 3 months. Long-term
results are necessary because the effectiveness of the treatment may deteriorate over
time. This is especially true in diabetic cases, because the etiological factors persist
and gastroparesis is complex with a multifactorial pathophysiological process in these
patients. All patients in this trial, and some new patients who have been treated
since the end of this study, are now included in a longer-term follow-up investigation
that includes clinical and scintigraphic re-evaluations over 5 years.
This prospective study confirmed the feasibility, safety, and potential efficacy of
G-POEM for treating refractory gastroparesis, particularly in patients with low pyloric
distensibility, as measured using Endoflip. Well-designed randomized trials and international
prospective studies, with clinically relevant end points and evaluation of the underlying
pathophysiology, are required. According to the difficulty and challenges linked to
this complex disease, with multiple different pathophysiologies involved, our results
must be interpreted with caution, particularly because 3 months is a short follow-up
in the long history of a gastroparetic patient.
