5 years of experience with DIBH (Deep inspiration breath-hold) combined with SGRT (Surface-Guided Radiation Therapy) in left-sided breast cancer

Abstract

Background Radiation treatment to the left breast is associated with increased cardiac morbidity as well as mortality. Deep inspiration breath-hold (DIBH) technique with Surface Guided Radiation Therapy (SGRT) could have dosimetric advantages over the free breathing technique (NB, normal breathing) in cardiac (heart and LAD) and ipsilateral lung sparing in patients with left-sided breast cancer after surgery. Therefore this technique was implemented in 2013 at the institute of radiooncology at the KFJ/SMZ-South – Hospital Vienna.

Methods From Oct 2013 – December 2018 548 patients were referred to radiotherapy following conservative operation of left-sided invasive breast cancer. All patients gave their informed consent and underwent training sessions for the DIBH-technique independent of age or breathing activity or respiratory disorders. Patients who turned out to be unfit for DIBH were enrolled for NB. The relative reduction in Dmean heart and left lung dose was compared between the two cohorts. Acute radiation induced side effects were classified according to the Radiation Therapy Oncology Group/The European Organisation for Research (RTOG) [37]; late toxicity rates according to the Common Terminology Criteria for Adverse Events (CTCAE Version 4.03)

Results The median age of the DIBH-patients was 58 years (27–90), of the NB-patients 65 (30–80) years. Follow-up was obtained until June 2019. The median follow-up was 52 months (range 7–73 m). The average coverage of Dmean left lung was 6.91 Gy (1.44 Gy – 12.4 Gy). The average coverage of Dmean heart was 1.17 Gy (0.12 Gy – 3.19 Gy) in the DIBH-cohort. The NB – plans had a Dmean of 8.92 Gy (5.23–16.9 Gy) at the ipsilateral lung and a Dmean of 2.31 Gy (0.71–4.21 Gy) at the heart. This shows that the DIBH-technique halved the Dmean of the heart. The amount of acute side effects was comparable between the two groups: RTOG 1: 70.8 % vs. 64 %, RTOG 3 6.6 % vs. 5.6 %, no reaction 3.2 % vs. 1.4 %. There were more CTCAE 1-late events in the NB-group (51.6 % vs. 12.67 %).

Conclusion Deep inspiration breath-hold (DIBH) technique with Surface Guided Radiation Therapy (SGRT) is a rather simple, reproducable method with a high acceptance of the patients who can actively participate in the whole treatment process. The mean dose at the heart and the left lung can be reduced, at the heart even by as much as 50 %.

Key words

breast cancer - breast irradiation - cardiotoxicity - DIBH - SGRT

Schlüsselwörter

Brustkrebs - Brustbestrahlung - Kardiotoxizität - DIBH - SGRT

Background

Worldwide breast cancer is the most common cancer affecting women. Adjuvant radiotherapy plays a central role after breast conserving surgery in early-stage breast cancer. A considerable number of trials [12] [13] [18] [19] [23] [24] [29] [34] has shown on the one hand a reduction in recurrence and death rates from breast cancer and on the other hand an improvement in overall survival with adjuvant radiotherapy. A large meta-analysis by the Early Breast Cancer Trialist’s Group [23] found that patients treated with radiation therapy after breast-conserving surgery (BCS) had a 7 % chance of local recurrence after 5 years compared with 26 % in patients who did not undergo radiotherapy. Additionally they had an absolute risk reduction of 5.4 % in breast related mortality with radiation therapy after BCS compared with BCS alone.

Despite its improvements, radiotherapy to the breast can cause side effects. A long-term complication of left breast irradiation is the risk of cardiac mortality and morbidity as well as pulmonary complications as multiple epidemiological studies have shown [18] [24]. Darby et al. [16] found after retrospectively analyzing 2168 patients from the Nordic cancer registry that the relative risk for ischemic heart disease increased by 7.4 % for every 1 Gray (Gy) in mean heart dose. However especially the Ramus interventricularis anterior (RIVA; left anterior descending coronary artery- LADCA) has a high risk of obtaining significant higher doses and is responsible for the development of pathologic blood vessel disorder and myocardial or coronary artery disease [1] [20] [21] [22].

Modern radiation treatment techniques may reduce the dose to the heart. For this purpose the deep inspiration breath-hold technique has made considerable efforts to reach this goal in minimizing the dose to the heart [3] [4] [5] [6] [7] [8] [9] [10] [11] [14]. The technique is based upon the observation that during inspiration, the flattening of the diaphragm and the expansion of the lungs pull the heart away from the chest wall. Deep inspiration breath hold (DIBH) is a radiation therapy technique where patients take a deep breath during treatment to a specific threshold and hold this level of inspiration during every radiation therapy field delivered. By taking a deep breath in, the lungs fill with air and thus the heart will move away from the chest.

SGRT (Surface Guided Radiation Therapy) is a system to position and monitor the patient’s external surface during their radiation treatments to ensure they are in the correct position. It matches surface data in real-time and tracks the patient in all six degrees of freedom to a reference model captured either during the planning process or using the internal imaging in the treatment room. SGRT can be used both in setup and therapy for breast cancer patients, DIBH, SRS, SBRT, thoracic lesions and many more. With SGRT, the radiation treatment can be delivered much more accurately to the intended target for every patient than with other techniques.

The DIBH technique with SGRT (Catalyst System) was adopted and clinically implemented at the institute of radiation oncology at the KFJ/SMZ-South Vienna in October 2013 for all patients with left-sided breast-cancer. The aim of this report is to provide our experiences regarding the implementation, utilization, patient compliance, planning methods, treatment verification, dosage and limits of the DIBH-technique with SGRT. The primary goal was to evaluate if there would be a relative reduction in Dmean heart and left lung dose between the two cohorts (DIBH vs. NB).

Patients and methods

Patients

Between Oct 2013 -and December 2018 548 consecutive patients with histologically confirmed breast cancer were enrolled. The patients were referred to radiotherapy following conservative surgery of left-sided invasive breast cancer. All eligible patients were informed about the potential benefit of an additional deep inspiration breath hold. Part of our daily clinical routine is that all patients are offered the oppurtunity to try the training session for the DIBH-technique independent of age or breathing activity or respiratory disorders. Patients who turned out to be unfit for DIBH were enrolled for NB.

Data was collected by analysing patients records. All treatments described in the present report were carried out in accordance with national law. Before starting the entire treatment procedures, all patients had to give their informed consent for the treatment in DIBH (deep inspiration breath hold) and also for the NB (normal breathing)-method.

Treatment prescriptions

Postoperative RT is strongly recommended after BCS [31] [32] [34]. A whole breast radiation therapy (WBRT) alone reduces the 10-year risk of any first recurrence (including locoregional and distant) by 15 % and the 15-year risk of breast cancer-related mortality by 4 % [34]. Boost irradiation gives a further 50 % RR reduction. It is indicated for patients who have unfavourable risk factors for local control such as: age < 50 years, grade 3 tumours, extensive DCIS, vascular invasion or non-radical tumour excision [31] [32] [34]. Doses used for local and/or regional adjuvant irradiation have traditionally been 45–50 Gy in 25–28 fractions of 1.8–2.0 Gy with a typical boost dose of 10–16 Gy in 2 Gy single doses. Shorter fractionation schemes (e. g. 15–16 fractions with 2.5–2.67 Gy) were also used according to the Start B protocol [17] [29] [35] [36] or the Whelan regimen [19]. An irradiation of the axillary lymph nodes with 50 Gy in 25 fractions as specified by guidelines [12] was performed when indicated. Nevertheless at our institute it is extremely seldom that an irradiation of the internal mammary nodes [13] is carried out according to the AGO-and/or S3-guidelines [31] [32] – however, in this cohort no treatment of the lymph nodes of the A. mammaria interna was performed.

Workflow and system

Primarily all patients underwent the same workflow:

• Training session for DIBH: upper and lower thresholds of breathing can be fixed, positioning of respiratory marker block (with integrated infrared reflectors), audio- and video feedback

• CT-Scan in DIBH and or additionally in NB; for immobilization we used breast boards with both arms positioned above the head in a spine position

• Planning and verification (either in DIBH or if not possible in NB)

• Daily treatment

• Daily imaging with an adaptive planning approach

• Psychological support and information once a week in order to enable a return to normal life after breast cancer

At our institute the Varian Real-time Position Management™ (RPM) system and the Catalyst™ software and system from C-Rad are used. RPM is a non-invasive, video-based system that allows for clean imaging and treatment of lung, breast, and upper abdominal sites. The RPM system accommodates both breath hold and free breathing protocols. The Catalyst system for real time patient tracking captures the complete body surface of the patient continuously, compares the current patient posture and position to the previously recorded reference setup in real-time, detects intra-fraction motion and is also used for respiratory gating as shown in [Fig. 1]. The unit is mounted on the ceiling where it has an unobstructed view of the patient independent of any motion of the gantry or its on-board imagers. The Catalyst™ software has a tight connection and integration with the Varian RPM system. The specially designed filter monitors can predict the patient’s breathing pattern and can account for the patient’s coughing or changes from the predicted breathing pattern. The tumour position can be correlated in relation to the patient’s respiratory cycle. Using an infrared tracking camera and a reflective marker, the system measures the patient’s respiratory pattern and range of motion and displays them as a waveform.

Fig. 1 SGRT using a phantom for real time patient tracking at KFJ Vienna; the tumour position can be correlated in relation to the patient’s respiratory cycle.

The gating thresholds are set when the tumor is in the desired position of the respiratory cycle. These thresholds determine when the gating system turns the treatment beam on and off [25] [26] [27] as illustrated in [Fig. 2].

Fig. 2 Respiratory pattern in DIBH (deep-inspiration-breath-hold)-technique – deep inspiration within upper and lower thresholds; “beam” on is illustrated by yellow bar.

In this way the dose to the heart can be minimized in our breast treatments, the maximum heart distance of the heart irradiated is less than 1 cm ([Fig. 3]).

Fig. 3 Radiotherapy of left-sided breast cancer in DIBH – maximum heart distance of heart irradiated is less than 1 cm.

Furthermore the patients are treated with two identical Varian Truebeam linear accelerators with an integrated “Perfect Pitch” (6-DoF-couch), a computer-controlled robotic treatment couchtop with remote positioning correction and 6 degrees of freedom [28]. The modern planning techniques included IMRT (intensity modulated radiotherapy)-, FIF (field in field) – and standard techniques. The targets (whole breast or chest wall +/– axillary lymph nodes), organs at risk (ipsilateral lung, contralateral lung, heart and contralateral breast) and other organs of interest were delineated as per the RTOG (Radiation Therapy Oncology Group) contouring recommendations [33].

Follow up schedule and statistical analysis

Our routine care programme lasts on average ten years; follow up was routinely scheduled every 3 months in the first year following radiotherapy, every 6 months in the second year and at 12-month intervals thereafter. If possible, acute radiation induced side effects were classified according to the Radiation Therapy Oncology Group/The European Organisation for Research (RTOG) [37]; late toxicity rates according to the Common Terminology Criteria for Adverse Events (CTCAE Version 4.03) [38]. Toxicity was considered early if it occurred within the first 90 days from the start of radiotherapy. Other assessments include: the complete new personal medical history, a physical examination, imaging, a full blood count, liver and renal function tests, alkaline phosphatase and calcium levels, an assessment of the menopausal status of the patient, a bone densitometry every two years and an evaluation of the cardiac function with a cardiac ultrasound or a multigated acquisition scan.

The outcomes evaluated in this retrospective analysis were primarily the feasibility and the workflow of DIBH with SGRT and secondarily, demographics as treatment-regimens and dosimetric outcomes like Dmean of the lungs and the heart. The statistical analysis was performed with the SPSS (Version 20) and Excel Office 2017; the primary goal of this analysis was an inter-cohort comparison.

The project has been displayed to the ethics committee and meets the requirements of the local guideline.

Results

Demographics

From Oct 2013 – Mai 2018 548 patients were enrolled, 517 of them could receive the DIBH-technique, 31 were treated in NB. We also treated 8 patients with right-sided breast cancer [2], 15 patients had both-sided breast cancer. Two male patients were included (0.4 %).

The median age of the DIBH-patients was 58 years (27–90), of the NB-patients 65 (30–80) years.

The majority of the patients were postmenopausal. No difference between the two groups was found regarding tumor site, TNMstaging, grading and hormonal receptor status. 100 patients received neoadjuvant systemic treatment (NACHT-regimen), 27 adjuvant chemotherapy, 453 antihormonal treatment and 50 patients had to undergo a Trastuzumab-regimen.

Almost all patients (94.3 %) had a breast-conserving surgery, 4.6 % of the patients had oncoplastic techniques such as glandular adaptation, local or distant flaps or mammoplasty permitting breast remodeling. Extremely radical and radical surgical treatment of breast cancer were not investigated in this cohort. Nevertheless 30 patients (5.5 %) had an Ablatio mammae. Sentinel Node Biopsy as a standard procedure was performed in 98 % of the cases, 18 patients received an additional Level I and/or Level II axilla dissection (23 % N+ of the patients).

The majority of the treated patients had the staging T1 (373) and N0 (416) as shown in [Table 1]. There was an equal distribution between grading G1, G2 and G3. 40 patients suffered from heart diseases, especially coronary heart disease; 24 patients had preliminary lung problems including bronchial asthma and severe COPD. A detailed comparison of the patient-related factors of both treatment groups may be found in [Table 1].

Table 1 Patient, disease and treatment characteristics.

		NB (n = 31)	DIBH (n = 517)
Age	Mean	65	58
	Min	30	27
	Max	80	90
Sex	Male	0	2
	Female	31	515
OP	AD	7	11
	Ablatio	3	27
	Sentinel	31	506
	BET	28	490
	Remodeling	2
Both sided		3	12
T	T1 (pT1 / pT1mi/ypT1)	24	349
	T2 (pT2 / ypT2)	1	76
	T3 (pT3 / ypT3)	2	8
	T4 (pT4 / ypT4)	0	3
	Tis (pTis/ypTis)	1	47
	ypT0	2	30
	ypTx	1	4
N	pN0 / ypN0	18	398
	N1 (N1 / N1a/N1mi)	9	79
	N2 (N2a)	1	2
	N3 (N3a)	1	4
	Nx	1	4
	No data	1	30
Grading	G1	4	77
	G2	20	271
	G3	4	123
	No data	3	46
Herceptin	Yes	3	47
	No	22	458
	No data	6	12
HRT	Yes	26	5
	No	5	458
	No data	0	17
CHT	Yes	5	99
	No	26	402
	No data	0	16
RTOG	RTOG1	22	331
	RTOG2	6	150
	RTOG3	2	29
	No reaction	1	7
CTCAE	CTCAE1	16	65
	CTCAE2	1	38
	G3–5	0	0
	No reaction	14	414

HRT = Hormontherapie; CHT = Chemotherapie; RTOG = Radiation Therapy Oncology Group/The European Organisation for Research; CTCAE = Common Terminology Criteria for Adverse Events.

Dose and fractionation prescribed in this analysis represent standard treatment prescriptions at our institution and the radiotherapy treatment characteristics are shown in [Fig. 4].

Fig. 4 Coverage of dose using 3 different RT-schemes.

51 % of all 548 enrolled patients received a total dose of 50 Gy in 25 fractions +/– boost irradiation (Standard protocol), 47 % of 40.05 Gy in 15 fractions (Start B protocol – 17, 29, 35, 36) and 2 % of 42.5 Gy in 16 fractions (Whelan protocol – 19). In 12 cases we irradiated the axillary lymph nodes with 50 Gy in 25 fractions as specified by guidelines [12]. Nevertheless it is interesting to note that 82 % of the NB – patients underwent a hypofractionation protocol ([Fig. 4]).

Dosimetric outcomes

The comparison of average dose parameters to the heart and left lung using DIBH vs. NB is summarized in [Fig. 5]. Actually great efforts were taken to optimize the treatment planning on the computed tomography data sets of the patients; in order to be able to pick the best plan we decided to create at least six plans per patient (Range 4–12 plans), some of them in free-breathing (NB). The average coverage of Dmean left lung was 6.91 Gy (Range 1.44 Gy–12.4 Gy) in the DIBH cohort. 75 % of all patients were able to meet a Dmean under 8.41 Gy. We also evaluated the NB plans. In this evaluation the Dmean left lung was 8.92 Gy (Range 5.23–16.9 Gy). This shows that the DIBH-technique reduced the Dmean at the ipsilateral lung around 2 Gray.

Fig. 5 Dmean for heart and left lung (Comparison NB vs. DIBH) – Dmean reduction heart by 45.4 %, ipsilateral lung by 22.5 %.

The high maximum in the DIBH group had one patient suffering from left heart failure with an enormous breast (V 2032.91 cc) and positive lymph nodes (5/12) receiving RT to the whole breast plus nodal RT. For this patient 12 different treatment plans were generated, three of them were normal breathing plans (NB) in order to be able to make a comparison it with the DIBH-plans. The Dmean left lung was much higher in the NB plans (the best NB-plan had a Dmean left lung of 16.9 Gy), thus we could reduce the dose to the left lung to around 4.5 Gy even in this special case. The treatment was well tolerated. Afterwards a close follow-up care quarterly was performed in the first 24 months. In this periode the patient developed neither radiation pneumonitis nor lung fibrosis.

Additionally, the DIBH technique reduced the Dmean of the heart compared to NB. The average coverage of Dmean heart was 1.17 Gy (Range 0.12 Gy – 3.19 Gy) in the DIBH cohort. 75 % of all patients were able to reach a Dmean under 1.55 Gy. The NB plans had a Dmean heart of 2.31 Gy (Range 0.71–4.21 Gy), which means that the DIBH-technique could halve the Dmean heart according to literature [16] [39] [54] [55] [56] [57] [58]. The maximum heart distance (maximal thickness of heart irradiated) was mostly less than 1 cm (Range 0.8–1.2 cm) during irradiation of our DIBH breast cancer cases, mostly less than 2 cm (Range 1.1–3.2 cm) in the NB plans.

In summary the Dmean heart could be reduced by 45.4 % compared with the NB-technique and the Dmean left lung by 22.5 % ([Fig. 5]).

Technical problems

In our series this innovative technique had to deal with different problems concerning breathing conditions (e. g. abdominal breathing, nervous breathing, respiratory problems), the cognitive situation of the patient (e. g. memory performance, memory loss, dementia and many more) and the barrier of language. Even the marker block sometimes caused trouble (e. g. lack of signal, block lies in the treatment field). In daily routine this technique was associated with a higher amount of work, the assumption of additional responsibility for the special working group, a high expenditure of time and probably additional costs. We determined that the additional time we needed was up to 40 minutes according to our time schedule (Range 32–52 min) when performing the virtual simulation. Apart from this it needed up to 10 extra-minutes in daily routine per patient for treatment delivery due to the breathing commands and the complex set up. Although this technique was time consuming, needed patient cooperation and technical expertise it clearly reduced the doses to the heart and left lung. Similar findings have been reported in literature [20] [42] [47].

Follow up

Follow-up was carried out until June 2019, at that time all patients were still alive. Median follow-up for all patients was 52 months (range 7–73 m). No relevant differences were found between both treatment groups. Side effects were classified according to the Radiation Therapy Oncology Group/The European Organisation for Research [37], there was a slight difference between both arms, the NB arm had less RTOG 2 skin reactions (NB: DIBH = 19.4 %:29 %). Apart from this the amount of the side effects was comparable (RTOG 1: 70.8 % vs. 64 %, RTOG 3 6.6 % vs. 5.6 %, no reaction 3.2 % vs. 1.4 %). Late toxicity rates according to the Common Terminology Criteria for Adverse Events Version 4.03 (including teleangiectasia, skin and subcutaneous tissue disorders, skin atrophia, skin hyperpigmentation, pruritus, skin induration, skin ulceration) were distributed similarly, however we noted a higher teleangiectasia rate in patients who received a systemic therapy with chemotherapy and trastuzumab. Additionally there were 4 times more CTCAE 1 events in the NB-arm (51.6 % vs. 12.67 %). One reason for this could be that the hypofractionation regimen was used in 82 % of the NB-patients. Grade 3–5 late side effects did not occur in both arms. A detailed comparison of the group-specific toxicity results is depicted in [Table 1], [Fig. 6].

Fig. 6 Comparison DIBH and NB patients: acute side effects RTOG-classification, late side effects CTCAE-criteria.

Discussion

Cardiac toxicity after breast cancer [16] [34] [48] [52], lung cancer [53] [54] and mediastinal lymphoma [49] [50] [59] is the most reported radiation-induced complication [51]. The common clinical complications are asymptomatic pericarditis, congestive heart failure, and heart infarction. Even though clinicians have to give particular attention to these complications, anthracycline treatment [60] [61] [62]) is an additional major risk factor for additional cardiotoxicity during radiotherapy with a synergistic effect. However, the use of anthracycline, other cardiotoxic chemotherapies, immunotherapy [63] [64] [65] and targeted therapies [66] [67] should only be used with great caution and only after carrying out a careful treatment plan and optimization [1] [30] [40].

There is a wealth of evidence from retrospective and planning studies demonstrating reduction in dose to the heart and coronary arteries with DIBH treatment of left-sided breast cancers [10] [14] [15]. Additionally the total dose delivered to the planning target volume (PTV), the dose per fraction and the irradiated volume are correlated to the risk of cardiotoxicity. Remarkably, the volume of the heart receiving 35 Gy must be less than 30 % and dose per fraction should not exceed 2 Gy when dose of prescription exceeds 30 Gy as previous studies confirmed [30]. On the one hand Darby et al. [16] showed a dose/effect-relationship with an increase in the relative risk of acute major coronary events of 7.4 % per Gy (95 % confidence interval, CI: 2.9–14.5; p < 0.001) mean heart dose within 20 years, on the other hand Van den Bogaard et al. [58] found a relative increase in the cumulative incidence of acute coronary events (ACE) of 16.5 % per Gray(hazard ratio, HR: 1.165; 95 % CI for HR: 1.006 to 1.350; p  = 0.042) of mean heart dose within 9 years of RT.

Modern irradiation techniques seem to be associated with a limited risk of heart complication. Taylor et al. [21] [56] [57] comparatively analyzed mean heart doses from left tangential RT to cardiac structures over several decades, and described reductions in mean heart dose from 13.3 Gy in the 1970 s, to 4.7 Gy in the 1990 s, and 2.3 Gy in 2006 due to major advances in RT techniques. Deep inspiration breath hold (DIBH) reduces heart and left anterior descending artery (LAD) dose during left-sided breast radiation therapy (RT); however there is limited information about which patients derive the most benefit from DIBH. Our study results are similar to published retrospective and planning studies demonstrating that DIBH lowered Dmean Heart and LAD doses [2] [4] [8] [10] [14] [15] [41]. Based on available findings, the DEGRO breast cancer expert panel recommends a Dmean heart dose < 2.5 Gy [55]. Additionally, the study of Yeung et al. [39] showed that all patients receiving WBRT (whole breast irradiation) with DIBH met a Dmean heart < 4 Gy and had less heart problems. Remarkably, in our series all patients with DIBH could reach a Dmean heart < 1.2 Gy and almost all patients with NB a Dmean heart < 2.3 Gy which means that our data could comply the DEGRO-recommendations.

However, proton therapy is another breast cancer radiation modality used to spare heart radiation exposure, taking advantage of the dosimetric properties of protons to reduce cardiac doses. Recent series have shown remarkably low cardiac doses with proton therapy [43]. Comparisons of protons at free-breathing versus photons with DIBH have shown that both techniques yield remarkably low heart doses, although proton plans appear to deliver lower mean heart dose and lower dose to the LAD [44] [45]. This may be answered by the PCORI RADCOMP trial [46]. This trial aims to enroll 1716 patients receiving radiotherapy to the breast or chestwall in conjunction with the internal mammary nodes and randomizes them to radiotherapy with either protons or photons. The primary endpoints of this trial are cardiac events and cancer control events.

Nevertheless limits of our analysis are the retrospective design, the lack of randomization and follow up in terms of recurrence probability. It is possible that the small sample sizes used in this retrospective analysis did not achieve the statistical power to show a significant effect. Further prospective studies with larger sample sizes are required to determine if there is a statistical difference between NB and DIBH and to determine threshold doses to cardiac structures in breast radiotherapy.

Conclusion

To sum up the Deep inspiration breath-hold (DIBH) technique with Surface Guided Radiation Therapy (SGRT) is a rather simple method with a high acceptance by patients who can actively participate in the whole treatment process. With appropriate patient selection and adequate training the treatment delivery is acceptable and feasible. DIBH with SGRT should be considered for all patients receiving RT for left-sided breast cancer. In particular, patients with breast/chest wall RT plus nodal RT seem to benefit most. In our cohort the reproducibility and stability of the combination of DIBH with SGRT was evident.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Publikationsverlauf

Artikel online veröffentlicht:
09. März 2020