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Tierarztl Prax Ausg K Kleintiere Heimtiere 2021; 49(05): 390-396
DOI: 10.1055/a-1528-1763
Case Report

Mycobacterium setense isolated from a cat with atypical mycobacterial panniculitis

Pannikulitis durch Mycobacterium setense bei einer Katze
Neoklis Apostolopoulos 
1   Small Animal Clinic, Veterinary Faculty, Justus-Liebig-University, Giessen, Germany
,
Ellen Prenger-Berninghoff
2   Institute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-University, Giessen, Germany
,
Brett Wildermuth
3   Tierdermatologie Dr. Wildermuth, Wiesbaden, Germany
,
Irmgard Moser
4   Friedrich-Loeffler-Institut, National Reference Laboratory for Bovine Tuberculosis, Institute of Molecular Pathogenesis, Jena, Germany
,
Doris Hillemann
5   National Reference Laboratory for Mycobacteria, Research Center Borstel, Borstel, Germany
,
Daniel Nobach
6   Institute for Veterinary Pathology, Justus-Liebig-University, Giessen, Germany
,
Christiane Herden
6   Institute for Veterinary Pathology, Justus-Liebig-University, Giessen, Germany
,
Christa Ewers
2   Institute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-University, Giessen, Germany
,
Nina Thom
1   Small Animal Clinic, Veterinary Faculty, Justus-Liebig-University, Giessen, Germany
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Zusammenfassung

Bei einer Katze wurde eine atypische mykobakterielle Pannikulitis diagnostiziert. Mittels 16S-rRNA-Gen-Sequenzanalyse ließ sich Mycobacterium setense, ein grampositives stäbchenförmiges säurefestes Bakterium der Mycobacterium fortuitum-Gruppe nachweisen, das zuvor nie bei einem erkrankten Tier isoliert werden konnte. Initial wurden Resistenzen gegen Doxycyclin und Clarithromycin festgestellt und während der Behandlung mit Pradofloxacin entwickelte sich zudem eine Resistenz gegen Fluorchinolone, bedingt durch eine Mutation im Gyrasegen gyrA (S90W-Austausch). Trotz einer langfristigen antimikrobiellen Behandlung über 33 Monate wurde keine vollständige Heilung erzielt. Bei einer atypischen mykobakteriellen Pannikulitis ist die Speziesbestimmung mit Resistenztest die Grundlage für eine adäquate Antibiose.

Abstract

Atypical mycobacterial panniculitis was diagnosed in a cat. Mycobacterium setense was identified as causative agent by 16 S rRNA gene sequence analysis. This a gram-positive rod-shaped acid-fast bacterium belonging to Mycobacterium fortuitum group was never reported before in diseased animals. Resistance to doxycycline and clarithromycin was detected. During treatment with pradofloxacin, additional resistance to fluoroquinolones developed which was due to a mutation in the gyrase gene gyrA (S90W exchange). Despite of antimicrobial treatment for 33 months the patient did not fully recover. Species identification and susceptibility testing for choosing adequate antimicrobial treatment is recommended in cases of feline mycobacterial panniculitis.

Schlüsselwörter

Antimikrobielle Resistenz - schnell wachsende Mykobakterien - Mycobacterium fortuitum-Gruppe - 16S-rRNA-Gen - gyrA

Key words

Antimicrobial resistance - rapidly growing mycobacteria - Mycobacterium fortuitum group - 16 S rRNA gene - gyrA

Supplementary material



Publication History

Received: 19 November 2020

Accepted: 21 January 2021

Article published online:
24 June 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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