ABDOMEN/BECKEN – No-Touch-Radiofrequenzablation überzeugt bei kleinen hepatozellulären Karzinomen

Europäische Leitlinien empfehlen bei sehr frühen hepatozellulären Karzinomen die Radiofrequenzablation als Alternative zur chirurgischen Resektion. Hauptnachteil ist die schlechtere lokale Tumorkontrolle. Die No-Touch-Technik generiert ein Ablationsfeld und verhinderte in der klinischen Studie die lokale Tumorprogression.

Publication History

Article published online:
25 May 2022

• Literatur

• 1 Yang Y. et al. Liver resection versus radiofrequency ablation for recurrent hepatocellular carcinoma: a systematic review and meta-analysis. Int J Hyperthermia 2021; 38: 875-886
• 2 Cha DI, Song KD, Kang TW. et al. Small masses (</=3 cm) diagnosed as hepatocellular carcinoma on pre-treatment imaging: comparison of therapeutic outcomes between hepatic resection and radiofrequency ablation. Br J Radiol 2020; 93: 20190719
• 3 Uhlig J, Sellers CM, Stein SM. et al. Radiofrequency ablation versus surgical resection of hepatocellular carcinoma: contemporary treatment trends and outcomes from the United States National Cancer Database. Eur Radiol 2019; 29: 2679-2689
• 4 Benson AB. et al. Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2021; 19: 541-565
• 5 AWMF. Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF): Diagnostik und Therapie des Hepatozellulären Karzinoms und biliärer Karziome, Langversion 2.0, 2021, AWMF Registernummer: 032/053OL. https://www.leitlinienprogramm-onkologie.de/leitlinien/hcc-und-billiäre-karzinome
• 6 Xuan D, Wen W, Xu D. et al. Survival comparison between radiofrequency ablation and surgical resection for patients with small hepatocellular carcinoma: A systematic review and meta-analysis. Medicine (Baltimore) 2021; 100: e24585
• 7 Wen L. et al. A Radiomics Nomogram for Preoperative Prediction of Early Recurrence of Small Hepatocellular Carcinoma After Surgical Resection or Radiofrequency Ablation. Front Oncol 2021; 11: 657039
• 8 Santambrogio R. et al. Micronvasive behaviour of single small hepatocellular carcinoma: which treatment?. Updates Surg 2021; 73: 1359-1369
• 9 Lee S. et al. Effect of Microvascular Invasion Risk on Early Recurrence of Hepatocellular Carcinoma After Surgery and Radiofrequency Ablation. Ann Surg 2021; 273: 564-571
• 10 Lin CH. et al. Minimally invasive surgery versus radiofrequency ablation for single subcapsular hepatocellular carcinoma </= 2 cm with compensated liver cirrhosis. Surg Endosc 2020; 34: 5566-5573
• 11 Hocquelet A. et al. Comparison of no-touch multi-bipolar vs. monopolar radiofrequency ablation for small HCC. J Hepatol 2017; 66: 67-74
• 12 Wang C. et al. Multicenter randomized controlled trial of percutaneous cryoablation versus radiofrequency ablation in hepatocellular carcinoma. Hepatology 2015; 61: 1579-1590
• 13 Dodd 3^rd GD, Frank MS, Aribandi M. et al. Radiofrequency thermal ablation: computer analysis of the size of the thermal injury created by overlapping ablations. Am J Roentgenol 2001; 177: 777-782
• 14 Tacke J, Mahnken A, Roggan A. et al. Multipolar radiofrequency ablation: first clinical results. Rofo 2004; 176: 324-329
• 15 Bruners P, Schmitz-Rode T, Gunther RW. et al. Multipolar hepatic radiofrequency ablation using up to six applicators: preliminary results. Rofo 2008; 180: 216-222
• 16 Bale R. et al. Stereotactic Radiofrequency Ablation of Hepatocellular Carcinoma: a Histopathological Study in Explanted Livers. Hepatology 2019; 70: 840-850
• 17 Fukutomi S. et al. Evaluation of hepatocellular carcinoma spread via the portal system by 3-dimensional mapping. HPB (Oxford) 2017; 19: 1119-1125