Shyam Menon et al. Stratification of Barrett’s esophagus surveillance based on p53
immunohistochemistry: a cost-effectiveness analysis by an international collaborative
group
Surveillance of Barrett’s esophagus (BE) based on p53 immunohistochemistry (IHC) was
compared with conventional BE surveillance in a Markov model. Surveillance based on
abnormal p53 IHC appeared to be cost-effective, with an incremental cost–effectiveness
ratio (ICER) of $8258, and was associated with a 14% reduction in endoscopy burden
and a 59% increase in dysplasia detection. This p53-based surveillance strategy will
improve the cost-effectiveness and reduce the unnecessary burden of BE surveillance,
both for patients and healthcare systems.
