Synthesis of Isatins via Oxone^®/TBAI-Mediated On-Water Oxidation of Indoles

Abstract

Isatins and their derivatives are important scaffolds in a wide range of pharmaceuticals, bioactive compounds, and functional materials. Herein we describe a new strategy for the synthesis of isatins from indoles via Oxone^®/TBAI-mediated oxidative dearomatization of indoles in water. The strategy works well with a variety of N-protected indoles and azaindoles.

Key words

isatins - indoles - oxidation - dearomatization - water

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