Zhou P,
Wang P,
Zhu H,
Zhang J,
Peng Q *,
Tao Z *.
Nankai University, Tianjin, Hunan University, Changsha, and Hunan University, Guangzhou,
P. R. China
Dinickel-Catalyzed Enantioselective Reductive Addition of Imines with Vinyl Halides.
Nat. Commun. 2025;
16: 8871
DOI:
10.1038/s41467-025-63940-y
Keywords
bimetallic catalysis - reductive coupling - nickel catalysis - allylamines
Significance
Peng, Tao and co-workers report an elegant synthesis of enantioenriched allyl amines
and allyl alcohols under dinickel catalysis. The reaction conditions exhibit broad
functional group tolerance including other halides and boronic esters.
Comment
Mechanistic studies support two-electron processes throughout the reaction. Exposure
of the reaction to DNPO led to comparable yields and enantioselectivities. A cyclopropyl
imine substrate did not undergo ring opening.
