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Synfacts 2009(7): 0708-0708  
DOI: 10.1055/s-0029-1217245
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Quinocarcin

Contributor(s): Philip Kocienski, Stewart Eccles
K. M. Allan, B. M. Stoltz*
California Institute of Technology, Pasadena, USA
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Quinocarcin (and its derivatives) have antiproliferative activity against lymphocytic leukemia, non-small cell lung cancer and adenocarcinoma. The key step is the annulation of the aryne derived from silyl aryltriflate G with N-acyl enamine F to give the isoquinoline H.