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Synfacts 2009(12): 1314-1314  
DOI: 10.1055/s-0029-1218322
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Agelastatin A

Contributor(s): Philip Kocienski
N. Hama, T. Matsuda, T. Sato, N. Chida*
Keio University, Yokohama, Japan
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

(-)-Agelastatin A is a metabolite of the sponge Agelas dendromorphia. It is an antimetastic agent through the inhibition of osteo­pontin and it selectively inhibits glycogen synthase kinase-3β (GSK-3β).