Quaternary Stereocenters Generated by Conjugate Addition
of α-Cyano Ketones

doi:10.1055/s-0029-1220110

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Synfacts 2010(7): 0791-0791
DOI: 10.1055/s-0029-1220110

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Quaternary Stereocenters Generated by Conjugate Addition of α-Cyano Ketones

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
Y. Kawato, N. Takahashi, N. Kumagai*, M. Shibasaki*
The University of Tokyo, Japan

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Publikationsverlauf

Publikationsdatum:
22. Juni 2010 (online)

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Significance

Highly functionalized molecules with an all-carbon quaternary stereocenter can be readily attained with ligand 1 and Y(Oi-Pr)₃. This nice catalyst system can be further used to synthesize enantioenriched bicyclic compounds, which can have synthetic value.