Zeitschrift für Phytotherapie 2009; 30(3): 148-154
DOI: 10.1055/s-0029-1231085
Porträt einer Arzneipflanze
© Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Ecballium elaterium (L.) A. Rich. – die Eselsgurke

Klaus Peter Latté
Further Information

Publication History

Publication Date:
03 July 2009 (online)

Zusammenfassung

Ecballium elaterium, die Esels- oder Spritzgurke, aus der Familie der Cucurbitaceae, ist seit der Antike im Mittelmeerraum als Arzneipflanze bekannt. Auch heute noch werden Fruchtsaftextrakte in der traditionellen Medizin verschiedener mediterraner Länder eingesetzt, so z.B. bei Sinusitis, Entzündungen, Rheuma, Leberbeschwerden und Gelbsucht. Viele dieser Anwendungsgebiete konnten in pharmakologischen Untersuchungen zumindest in vitro – teilweise auch in vivo, insbesondere bei Sinusitis – bestätigt werden. Phytochemisch wurden zahlreiche Triterpene, vor allem Cucurbitacine, isoliert, die mit der Wirkung in Verbindung gebracht werden.

Summary

Ecballium elaterium (L.) A. Rich. – Portrait of a medicinal plant

Ecballium elaterium, the squirting cucumber, from the Cucurbitaceae family, has been known in the Mediterranean area as a medicinal plant since antiquity. Extracts of the fruit are still used in different folk medicinal systems in the Mediterranean region, especially as a curative agent against sinusitis, inflammation, rheumatism, liver disorders and jaundice. Many of these indications could be confirmed by pharmacological studies at least in vitro, in part also in vivo, e.g. against sinusitis. Phytochemical analyses of the fruit extracts have led to the isolation of several triterpenoids, especially of a series of cucurbitacins, which explain at least in part the pharmacological activities.

Literatur

  • 1 Agil MA, Risco S, Miró M, et al.. Analgesic and antipyretic effects of Ecballium elaterium (L.) A. Richard. extract in rodents.  Phytother Res. 1995;  9 135-138
  • 2 Agil A, Miró M, Jiménez J, et al.. Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium .  Planta Med. 1999;  65 673-675
  • 3 Alqasoumi SI, Abdel-Kader MS. Screening of traditional Saudi plants for hepatoprotective effect.  Planta Med. 2008;  74 1139
  • 4 Attard E, Scicluna-Spiteri A. The cultivation and cucurbitacin content of Ecballium elaterium (L.) A. Rich.  CGC Report. 2003;  26 66-69
  • 5 Başaran AA, Çakmak EA, Degirmenci T, et al.. Chromosome aberrations induced by aflatoxin B1 in rat bone marrow cells in vivo and their suppression by Ecballium elaterium .  Fitoterapia. 1993;  64 310-313
  • 6 Başaran AA, Yu T-W, Plewa MJ, Anderson D. An investigation of some Turkish herbal medicines in Salmonella typhimurium and in the COMET assay in human lymphocytes.  Terat Carc Mutag. 1996;  16 125-138
  • 7 Başaran AA, Ceritolu I, Ündeer Ü, Başaran N. Immunomodulatory activities of some Turkish medicinal plants.  Phytother Res. 1997;  11 609-611
  • 8 Besler B. Der Garten von Eichstätt. Nürnberg, 1613. Köln; Taschen 2007 (Nachdruck): Abbildung 284
  • 9 Caiozzi GA, Cabrera DT, Mardónez JMU, Saldías FP. Hierbas medicinales y graves efectos adversos: Angioedema de úvula causado por uso de Ecballium elaterium .  Rev Méd Chile. 2002;  130 1407-1410
  • 10 Chakravarty AK, Das B, Masuda K, et al.. Triterpenoid glycosides from fruits of Ecballium elaterium .  J Ind Chem Soc. 1997;  74 858-863
  • 11 Chen JC, Chiu MH, Nie RL, et al.. Cucurbitacins and cucurbitane glycosides: structures and biological activities.  Nat Prod Rep. 2005;  22 386-399
  • 12 Chinou IB, Roussis V, Vagias C, Roussakis C. Differentiation-inducers from Ecballium elaterium L. on a non-small-cell bronchial carcinoma line. 2000 Years of Natural Products Research – Past, present and future. Amsterdam; 1999 Abstract 510
  • 13 Cogniaux A, Harms H. Cucurbitaceae, Cucurbitae, Cucumerinae. In: Engler A, Hrsg. Pflanzenreich – Regni vegetabilis conspectus. Leipzig; Verlag von Wilhelm Engelmann 1924: 94-97
  • 14 Costich DE. Gender specialization across a climatic gradient: Experimental comparison of monoecious and dioecious Ecballium .  Ecology. 1995;  76 1036-1050
  • 15 El Beyrouthy M, Arnold N, Delelis-Dusollier A, Dupont F. Plants used as remedies antirheumatic and antineuralgic in the traditional medicine of Lebanon.  J Ethnopharmacol. 2008;  120 315-334
  • 16 Ekící M, Satilmiş A, Ay YD, et al.. Ecballium elaterium (L.) meyvelerinin sinüzite karşi kullanimi.  Ekoloji. 1998;  27 24-25
  • 17 Elayan HH, Garaibeh MN, Zmeili SM, Salhab SA. Effects of Ecballium elaterium juice on serum bilirubin concentrations in male rats.  Int J Crude Drug Res. 1989;  27 227-234
  • 18 Fahn A, Shimony C. Nectary structure and ultrastructure of unisexual flowers of Ecballium elaterium (L.) A. Rich. (Cucurbitaceae) and their presumptive pollinators.  Ann Bot. 2001;  87 27-33
  • 19 Fuchs L. New Kreüterbuch. Basel, 1543. Köln; Taschen 2001 (Nachdruck): Kapitel 268
  • 20 Greige-Gerges H, Khalil RA, Mansour EA, et al.. Cucurbitacins from Ecballium elaterium juice increase the binding of bilirubin and ibuprofen to albumin in human plasma.  Chem Biol Interact. 2007;  169 53-62
  • 21 Hayne FG. Momordica elaterium . Getreue Darstellung und Beschreibung der in der Arzneykunde gebräuchlichen Gewächse. Berlin; Eigenverlag 1822 Band 8. Kapitel 45
  • 22 Janick J, Paris HS. The cucurbit images (1515–1518) of the Villa Farnesina, Rome.  Ann Bot. 2006;  97 165-176
  • 23 Janick J, Paris HS, Parrish DC. The cucurbits of Mediterranean antiquity. Identification of taxa from ancient images and descriptions.  Ann Bot. 2007;  98 1-17
  • 24 Kavalci C, Durukan P, Cevik Y, Özer M. Angioedema due to Ecballium elaterium: Case report.  Akad Acil Tip Derg. 2007;  3 39-40
  • 25 Khalil AM, Qaoud KM. Toxicity and partial characterization of Ecballium elaterium fruit juice.  Pharm Biol. 1993;  31 135-141
  • 26 Kloutsos G, Balatsouras DG, Kaberos AC, et al.. Upper airway edema resulting from use of Ecballium elaterium .  Laryngoscope. 2001;  111 1652-1655
  • 27 Köhler H. Der Fruchtsaft von Momordica elaterium in historischer, chemischer und physiologischer Hinsicht. I. Historischer Theil.  Virchows Arch. 1870;  49 408-434
  • 28 Köhler H. Der Fruchtsaft von Momordica elaterium in historischer, chemischer und physiologischer Hinsicht. II. Chemischer Theil.  Virchows Arch. 1870;  50 273-293
  • 29 Kokkonouzis I, Antoniou G, Varvaressos S, et al.. Upper airway edema due to nasal aspiration of undiluted juice of Ecballium elaterium: Report of three cases.  Am J Case Reports. 2008;  9 255-258
  • 30 Kültür S. Medicinal plants used in Kirklareli Province (Turkey).  J Ethnopharmacol. 2007;  111 341-364
  • 31 Lavie D, Szinai S. The constituents of Ecballium elaterium L. II. α-Elaterin.  J Am Chem Soc. 1958;  80 707-710
  • 32 Lavie D, Willner D. The constituents of Ecballium elaterium L. III. Elatericin A and B.  J Am Chem Soc. 1958;  80 710-714
  • 33 Lavie D, Willner D. The constituents of Ecballium elaterium L. XI. Proposed structures for α-Elaterin and its degradation products.  J Am Chem Soc. 1960;  82 1668-1673
  • 34 Lavie D, Shvo Y. The constituents of Ecballium elaterium L. X. Proposed structures for Elatericin A and B.  J Am Chem Soc. 1960;  82 966-970
  • 35 Lavie D, Shvo Y, Gottlieb OR, Glotter E. The constituents of Ecballium elaterium L. XVI. Stereochemical problems in the Cucurbitacins.  J Chem Soc. 1963;  28 1790-1795
  • 36 Lazaris D, Chinou I, Roussis V, et al.. Chemical constituents from Ecballium elaterium L. (Cucurbitaceae) and their effect on a non-small-cell bronchial carcinoma line. 45. Jahreskongress der Gesellschaft für Arzneipflanzenforschung, Regensburg 1997 Abstract K09
  • 37 Ljubuncic P, Azaizeh H, Portnaya I, et al.. Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel.  J Ethnopharmacol. 2005;  99 43-47
  • 38 Miró M. Cucurbitacins and their pharmacological effects.  Phytother Res. 1995;  9 159-168
  • 39 [Anonymous] .Flora Nordica. Cucurbitaceae: Ecballium A. Rich., nom. cons.  http://www.floranordica.org/Review/-Review_public/accounts/Cucurbitaceae.html; Stand: 02.12.2008
  • 40 Panosyan AG, Nikishchenko MN, Avetisyan GM. Structure of 22-Deoxocucurbitacins isolated form Bryonia alba and Ecballium elaterium .  Chem Nat Comp. 1986;  21 638-645
  • 41 Power FB, Moore CW. CCXVIII. – The constituents of the fruit of Ecballium elaterium .  J Chem Soc, Trans. 1909;  95 1985-1993
  • 42 Raikhlin-Eisenkraft B, Bentur Y. Ecballium elaterium (Squirting cucumber) – remedy or poison?.  Clin Toxicol. 2000;  38 305-308
  • 43 Rao MM, Meshulam H, Lavie D. The constituents of Ecballium elaterium L. XXIII. Cucurbitacins and hexanorcucurbitacins.  J Chem Soc, Perkin I. 1974;  22 2552-2556
  • 44 Rao MM, Lavie D. The constituents of Ecballium elaterium L. XXII. Phenolics as minor components.  Tetrahedron. 1974;  30 3309-3313
  • 45 Rencüzoullari E, Ila HB, Kayraldiz A, et al.. The mutagenic and antimutagenic effects of Ecballium elaterium fruit juice in human peripheral lymphocytes.  Russ J Genetics. 2006;  42 623-627
  • 46 Roth L, Daunderer M, Kormann K. Giftpflanzen – Pflanzengifte. 5. Aufl. Landsberg; Ecomed Verlagsgesellschaft 2008 : 316-317
  • 47 Satar S, Gokel Y, Toprak N, Sebe A. Lifethreatening uvular angioedema caused by Ecballium elaterium .  Eur J Emerg Med. 2001;  8 337-339
  • 48 Seger C, Sturm S, Haslinger E, Stuppner H. A new Cucurbitacin D related 16,23-epoxy derivative and its isomerization products.  Org Lett. 2004;  6 633-636
  • 49 Seger C, Sturm S, Mair ME, et al.. 1H and 13C NMR signal assignment of cucurbitacin derivatives from Citrullus colocynthis (L.) Schrader and Ecballium elaterium L. (Cucurbitaceae).  Magn Reson Chem. 2005;  43 489-491
  • 50 Seger C, Sturm S, Haslinger E, Stuppner H. NMR signal assignment of 22-Deoxocucurbitacin D and Cucurbitacin D from Ecballium elaterium L.  (Cucurbitaceae) Monatsh Chem. 2005;  136 1645-1649
  • 51 Seifert K, Elgamal MH. New cucurbitacin glucosides from Ecballium elaterium .  Pharmazie. 1977;  32 605-606
  • 52 Sezik E, Yesilada E. Clinical effects of the fruit juice of Ecballium elaterium in the treatment of sinusitis.  J Toxicol Clin Toxicol. 1995;  33 381-382
  • 53 Uslu C, Karasen RM, Sahin F, et al.. Effect of aqueous extracts of Ecballium elaterium Rich, in the rabbit model of rhinosinusitis.  Int J Ped Otorhingol. 2006;  70 515-518
  • 54 Yesilada E, Tanaka S, Sezik E, Tabata M. Isolation of an anti-inflammatory principle from the fruit juice of Ecballium elaterium .  J Nat Prod. 1988;  51 504-508
  • 55 Yesilada E, Tanaka S, Tabata M, Sezik E. Antiinflammatory effects of the fruit juice of Ecballium elaterium on edemas in mice.  Phytother Res. 1989;  3 75-76

Dr. Klaus Peter Latté

Warägerweg 21

13595 Berlin

Email: latte@zedat.fu-berlin.de

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