Rofo 2011; 183(3): 217-225
DOI: 10.1055/s-0029-1245903
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Neuroblastoma Imaging

Bildgebung des NeuroblastomsS. Ley1 , J. Ley-Zaporozhan1 , P. Günther2 , H. E. Deubzer3 , 4 , O. Witt3 , 4 , J.-P. Schenk1
  • 1Department of Diagnostic and Interventional Radiology, Devision of Pediatric Radiology, University Hospital Heidelberg
  • 2Division of Pediatric Surgery, University of Heidelberg
  • 3Childrens Hospital Heidelberg, Department of Pediatric Oncology
  • 4German Cancer Research Center, Clinical Cooperation Unit Pediatric Oncology
Further Information

Publication History

received: 17.4.2010

accepted: 2.11.2010

Publication Date:
17 December 2010 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Das Neuroblastom ist ein embryonaler Tumor des sympathischen Nervensystems und gehört zu den häufigsten soliden Malignomen des Kindesalters. Biologisches Verhalten und klinischer Verlauf weisen eine ausgeprägte Heterogenität auf, die von spontaner Regression bis zu unaufhaltsamer Progression reicht. Diese Übersichtsarbeit erläutert die Risikostratifizierung und therapeutischen Optionen. Eine ausführliche Darstellung der Aufgaben der Bildgebung während des Verlaufs der Erkrankung und typische bildmorphologische Befunde in allen Modalitäten werden dargestellt.

Abstract

Neuroblastoma is an embryonic tumor of the sympathetic nervous system which represents one of the most common malignancies in early childhood. Its clinical and biological behavior show a remarkable heterogeneity, ranging from spontaneous regression to inexorable progression with a fatal outcome. This review summarizes the clinical risk stratification and treatment options. An extensive overview of the role of imaging during the course of the disease and typical imaging findings in all imaging modalities are demonstrated.

Key words

abdomen - MR imaging - ultrasound - radionuclide imaging - neoplasms

References

  • 1 Lonergan G J, Schwab C M, Suarez E S et al. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.  Radiographics. 2002;  22 911-934
    Google Scholar
  • 2 Berthold F, Simon T. Clinical Presentation of Neuroblastoma. In Cheung N K, Cohn S L, eds Neuroblastoma. New York: Springer; 2005: 63-85
    Google Scholar
  • 3 Powell J E, Esteve J, Mann J R et al. Neuroblastoma in Europe: differences in the pattern of disease in the UK. SENSE. Study group for the Evaluation of Neuroblastoma Screening in Europe.  Lancet. 1998;  352 682-687
    Google Scholar
  • 4 Strenger V, Kerbl R, Dornbusch H J et al. Diagnostic and prognostic impact of urinary catecholamines in neuroblastoma patients.  Pediatr Blood Cancer. 2007;  48 504-509
    Google Scholar
  • 5 Olshan A F. Epidemiology of Neuroblastoma. In: Cheung NK, Cohn SL, eds. Neuroblastoma. New York: Springer; 2005: 1-5
    Google Scholar
  • 6 Amiel J, Laudier B, Attie-Bitach T et al. Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome.  Nat Genet. 2003;  33 459-461
    Google Scholar
  • 7 Mosse Y P, Laudenslager M, Longo L et al. Identification of ALK as a major familial neuroblastoma predisposition gene.  Nature. 2008;  455 930-935
    Google Scholar
  • 8 Escobar M A, Grosfeld J L, Powell R L et al. Long-term outcomes in patients with stage IV neuroblastoma.  J Pediatr Surg. 2006;  41 377-381
    Google Scholar
  • 9 Schweinitz von D, Hero B, Berthold F. The impact of surgical radicality on outcome in childhood neuroblastoma.  Eur J Pediatr Surg. 2002;  12 402-409
    Google Scholar
  • 10 Canete A, Jovani C, Lopez A et al. Surgical treatment for neuroblastoma: complications during 15 years’ experience.  J Pediatr Surg. 1998;  33 1526-1530
    Google Scholar
  • 11 Gunther P, Troger J, Holland-Cunz S et al. Surgical complications in abdominal tumor surgery in children. Experiences at a single oncological center.  Eur J Pediatr Surg. 2009;  19 297-303
    Google Scholar
  • 12 Cecchetto G, Mosseri V, De Bernardi B et al. Surgical risk factors in primary surgery for localized neuroblastoma: the LNESG1 study of the European International Society of Pediatric Oncology Neuroblastoma Group.  J Clin Oncol. 2005;  23 8483-8489
    Google Scholar
  • 13 Simon T, Hero B, Benz-Bohm G et al. Review of image defined risk factors in localized neuroblastoma patients: Results of the GPOH NB 97 trial.  Pediatr Blood Cancer. 2008;  50 965-969
    Google Scholar
  • 14 Gunther P, Schenk J P, Wunsch R et al. Abdominal tumours in children: 3-D visualisation and surgical planning.  Eur J Pediatr Surg. 2004;  14 316-321
    Google Scholar
  • 15 Gunther P, Ley S, Troger J et al. 3D Perfusion Mapping and Virtual Surgical Planning in the Treatment of Pediatric Embryonal Abdominal Tumors.  Eur J Pediatr Surg. 2008;  18 7-12
    Google Scholar
  • 16 Günther P, Göppl M, Tröger J et al. Surgical Planning for solid abdominal tumors in childhood. Analysis of the need and acceptance of computer-assisted 3D-Visualization.  Monatsschr Kinderheilkunde. 2008;  156 569-573
    Google Scholar
  • 17 Brodeur G M, Pritchard J, Berthold F et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.  J Clin Oncol. 1993;  11 1466-1477
    Google Scholar
  • 18 Hero B, Simon T, Horz S et al. Metastatic neuroblastoma in infancy: what does the pattern of metastases contribute to prognosis?.  Med Pediatr Oncol. 2000;  35 683-687
    Google Scholar
  • 19 Simon T, Hero B, Hunneman D H et al. Tumour markers are poor predictors for relapse or progression in neuroblastoma.  Eur J Cancer. 2003;  39 1899-1903
    Google Scholar
  • 20 Benz-Bohm G, Hero B, Gossmann A et al. Focal nodular hyperplasia of the liver in longterm survivors of neuroblastoma How much diagnostic imaging is necessary?.  Eur J Radiol. 2009;  ; Online first
    Google Scholar
  • 21 Meyer J S, Harty M P, Khademian Z. Imaging of neuroblastoma and Wilms’ tumor.  Magn Reson Imaging Clin N Am. 2002;  10 275-302
    Google Scholar
  • 22 Schenk J P, Schrader C, Zieger B et al. Referenzradiologie des Nephroblastoms: Diagnosegenauigkeit und Bedeutung für die präoperative Chemotherapie.  Fortschr Röntgenstr. 2006;  178 38-45
    Google Scholar
  • 23 Hiorns M P, Owens C M. Radiology of neuroblastoma in children.  Eur Radiol. 2001;  11 2071-2081
    Google Scholar
  • 24 Biasotti S, Garaventa A, Villavecchia G P et al. False-negative metaiodobenzylguanidine scintigraphy at diagnosis of neuroblastoma.  Med Pediatr Oncol. 2000;  35 153-155
    Google Scholar
  • 25 Goo H W. Whole-body MRI of neuroblastoma.  Eur J Radiol. 2009;  ; online first
    Google Scholar
  • 26 Uhl M, Altehoefer C, Kontny U et al. MRI-diffusion imaging of neuroblastomas: first results and correlation to histology.  Eur Radiol. 2002;  12 2335-2338
    Google Scholar
  • 27 Gahr N, Darge K, Hahn G et al. Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastoma/ganglioneuroma.  Eur J Radiol. 2010;  ; online first
    Google Scholar
  • 28 Goo H W, Choi S H, Ghim T et al. Whole-body MRI of paediatric malignant tumours: comparison with conventional oncological imaging methods.  Pediatr Radiol. 2005;  35 766-773
    Google Scholar
  • 29 Ley S, Ley-Zaporozhan J, Schenk J P. Whole-body MRI in the pediatric patient.  Eur J Radiol. 2009;  70 442-451
    Google Scholar
  • 30 Cody D D, Moxley D M, Krugh K T et al. Strategies for formulating appropriate MDCT techniques when imaging the chest, abdomen, and pelvis in pediatric patients.  Am J Roentgenol. 2004;  182 849-859
    Google Scholar
  • 31 Hammer G P, Seidenbusch M C, Schneider K et al. Inzidenz von Kinderkrebs nach Röntgendiagnostik im Patientenkollektiv der Jahre 1976 – 2003 einer Universitäts-Kinderklinik.  Fortschr Röntgenstr. 2010;  182 404-414
    Google Scholar

Dr. Sebastian Ley

Diagnostische und Interventionelle Radiologie, Universitätsklinik Heidelberg

Im Neuenheimer Feld 430

69120 Heidelberg

Germany

Phone: ++ 49/62 21/56 84 14

Fax: ++ 49/62 21/56 29 98

Email: sebastian.ley@med.uni-heidelberg.de

      >