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Synfacts 2011(1): 0013-0013  
DOI: 10.1055/s-0030-1258979
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of LY503430

Contributor(s): Philip J. Kocienski
B. Duthion, D. Gomez Pardo*, J. Cossy*
ESPCI ParisTech, France
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

LY503430 is a neuroprotective agent that reduces brain damage caused by 6-hydroxydopamine or the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). It is a lead for the treatment of Parkinson’s and ­Alzheimer’s disease, depression and schizophrenia. For a kg-scale synthesis of LY503430 based on a classical resolution, see: N. A. Magnus et al. Org. Process Res. Dev. 2005, 9, 621.