Direct Cross-Coupling of Diaryl Zinc Reagents

Paul Knochel; Jeffrey M. Hammann

doi:10.1055/s-0034-1380733

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Synfacts 2015; 11(6): 0641-0642
DOI: 10.1055/s-0034-1380733

Metal-Mediated Synthesis

Direct Cross-Coupling of Diaryl Zinc Reagents

Rezensent(en):

Paul Knochel

,

Jeffrey M. Hammann

Dunsford JJ, Clark ER, Ingelson MJ * University of Manchester, UK
Direct C(sp²)–C(sp³) Cross-Coupling of Diaryl Zinc Reagents with Benzylic, Primary, Secondary, and Tertiary Alkyl Halides.

Angew. Chem. Int. Ed. 2015;
54: 5688-5692

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Weitere Informationen

Publikationsverlauf

Publikationsdatum:
18. Mai 2015 (online)

Abstract
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Key words

zinc - alkyl halide - cross-coupling

Significance

Ingelson and co-workers developed an operationally simple method for the direct C(sp²)–C(sp³) cross-coupling of diarylzinc reagents with benzylic, primary, secondary, and tertiary alkyl halides, leading to the alkylated products in good yields.

Comment

The reactivity of this cross-coupling reaction was highly solvent dependent and showed excellent functional group tolerance. The products were generally obtained in good yields, and purification by column chromatography was not required.

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