Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2016; 12(3): 0281
DOI: 10.1055/s-0035-1561737
DOI: 10.1055/s-0035-1561737
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Copper-Catalyzed Asymmetric Cross-Aldol Reactions
Lin L, Yamamoto K, Mitsunuma H, Kanzaki Y, Matsunaga S, * Kanai M. The University of Tokyo and Japan Science and Technology Agency, Tokyo, Japan
Catalytic Asymmetric Iterative/Domino Aldehyde Cross-Aldol Reactions for the Rapid and Flexible Synthesis of 1,3-Polyols.
J. Am. Chem. Soc. 2015;
137: 15418-15421
Catalytic Asymmetric Iterative/Domino Aldehyde Cross-Aldol Reactions for the Rapid and Flexible Synthesis of 1,3-Polyols.
J. Am. Chem. Soc. 2015;
137: 15418-15421
Further Information
Publication History
Publication Date:
16 February 2016 (online)
Significance
The authors report copper-catalyzed asymmetric iterative and domino cross-aldol reactions. A variety of 1,3-polyols were obtained in high yields and high diastereo- and enantioselectivities.
#
Comment
In this reaction, the use of amine additives permits asymmetric triple and quadruple aldol reactions to be performed in a one-pot process. The method should be useful for the straightforward synthesis of enantiomerically and diastereomerically enriched 1,3-polyols.
#
#