Synlett 2017; 28(14): 1840-1844
DOI: 10.1055/s-0036-1588420
letter
© Georg Thieme Verlag Stuttgart · New York

A Convenient Strategy for Remote C–H Bond Halogenation of 8-Aminoquinolines in the C5 Position

Xiang-Xiang Chen
a   Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China
,
Jia-Xin Wang
a   Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China
,
Jiang-Tao Ren
a   Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China
,
Hu Xie
a   Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China
,
Yanxia Zhao
a   Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China
,
Ya-Min Li
b   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. of China   Email: sunmeng@nwu.edu.cn
,
Meng Sun*
a   Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi’an 710127, P. R. of China
› Author Affiliations
We are grateful to China Postdoctoral Science Foundation (2016M590967), Shaanxi Provincial Science and Technology Development Funds (2016JQ2022, 2016JQ2015), Shaanxi Provincial Postdoctoral Foundation (2016BSHEDZZ21), the National Fund for Fostering Talents of Basic Science (NFFTBS-J1103311, J1210057), and the National Natural Science Foundation of China (21402071) for financial support.
Further Information

Publication History

Received: 10 March 2017

Accepted after revision: 18 April 2017

Publication Date:
10 May 2017 (online)


These two authors contributed equally to this work.

Abstract

A highly efficient and convenient strategy has been developed for remote C–H bond halogenation of 8-aminoquinolines in good to excellent yields under transition-metal-free conditions. The reaction tolerates a variety of functional groups and can potentially be scaled up.

Supporting Information

Primary Data

 
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