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Synthesis 2017; 49(03): 526-531
DOI: 10.1055/s-0036-1588613
DOI: 10.1055/s-0036-1588613
short review
Li+-Controlled Diastereoselectivity of the Addition of Allenyl Cuprate Reagents to Aldehydes
Further Information
Publication History
Received: 02 September 2016
Accepted: 06 September 2016
Publication Date:
18 October 2016 (online)
In memory of Professor Jean Normant, with deepest respect and gratitude.
Abstract
This personal account summarizes our recent work regarding the addition of allenyl cuprates to aldehydes. An intertwined experimental and theoretical study enables highlighting of the crucial role of Li+ as a structuring agent in the different intermediates and transition states involved, and thus on the diastereochemical outcome of the reaction.
1 Introduction
2 Results and Discussion
3 Conclusion
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For some examples, see:
For the use of propargyl-allenyl copper(I) reagents, see: