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Synthesis 2017; 49(10): 2187-2204
DOI: 10.1055/s-0036-1588698
DOI: 10.1055/s-0036-1588698
paper
Fluorous Mixture Synthesis of Tripeptides and Pentapeptides Using a Fluorous-Fmoc Protection Strategy
Further Information
Publication History
Received: 28 November 2016
Accepted after revision: 05 January 2017
Publication Date:
06 February 2017 (online)
Abstract
A liquid-phase split-type synthesis of various tripeptides and pentapeptides was conducted using a fluorous-Fmoc protection strategy. Fluorous-Fmoc reagents were effectively used as both the protecting group for the amino function and the encoding tag for the amino acid structure. Several of the synthetic peptides prepared showed high activities in an ACE inhibitory assay.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588698.
- Supporting Information
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For representative examples, see:
For use of f-HPLC in separation of fluorous compounds, see: