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Synfacts 2016; 12(11): 1181
DOI: 10.1055/s-0036-1589316
DOI: 10.1055/s-0036-1589316
Metal-Mediated Synthesis
Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids
Further Information
Publication History
Publication Date:
18 October 2016 (online)
Significance
The authors report a palladium-catalyzed defluorinative coupling of 1-aryl-2,2-difluoroalkenes with boronic acids with a broad functional-group tolerance, moderate yields and excellent diastereoselectivity.
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Comment
The utility of the reported method was demonstrated by the synthesis of a Gleevec® amide isostere.
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