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Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids
Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes.
Angew. Chem. Int. Ed. 2016;
18 October 2016 (online)
The authors report a palladium-catalyzed defluorinative coupling of 1-aryl-2,2-difluoroalkenes with boronic acids with a broad functional-group tolerance, moderate yields and excellent diastereoselectivity.
The utility of the reported method was demonstrated by the synthesis of a Gleevec® amide isostere.