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Synfacts 2017; 13(06): 0601
DOI: 10.1055/s-0036-1590457
DOI: 10.1055/s-0036-1590457
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Enantioselective Palladium(II)-Catalyzed Borylation
Further Information
Publication History
Publication Date:
16 May 2017 (online)
Significance
The authors developed a palladium(II)-catalyzed borylation of cyclic amides by using chiral bidentate ligands. A wide variety of borylated cyclobutanes bearing an amide group were obtained with high selectivities.
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Comment
A transformation of the product, including the removal of the amide auxiliary, was accomplished to demonstrate the synthetic utility of the reaction. An asymmetric induction model is also proposed.
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