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Synthesis 2017; 49(15): 3476-3484
DOI: 10.1055/s-0036-1590471
DOI: 10.1055/s-0036-1590471
paper
Triazolylidene Ligands Allow Cobalt-Catalyzed C–H/C–O Alkenylations at Ambient Temperature
Generous support by the DFG (SPP 1807 ‘Control of London dispersion in molecular chemistry’) and the CaSuS PhD Programme (fellowship to N.S.) is gratefully acknowledged.Further Information
Publication History
Received: 21 April 2017
Accepted: 25 April 2017
Publication Date:
12 June 2017 (online)
Dedicated to Prof. Dr. Herbert Mayr
Abstract
Direct alkenylation through C–H/C–O cleavage was accomplished under mild reaction conditions by cobalt catalysts derived from novel triazolylidene ligands. The most effective ligand is characterized by sterically demanding substituents on the 1,4-N-atoms of the triazolylidene neighboring the carbene center. The C–H alkenylations proved viable with alkenyl acetates, carbamates, carbonates and phosphates. For acyclic electrophiles, diastereoconvergent C–O functionalizations were observed.
Supporting Information
- Supporting information for this article is available online at https://doi.org /10.1055/s-0036-1590471.
- Supporting Information
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For selected examples, see:
For reviews, see:
For representative examples, see:
For reviews on C–O activation, see: