Keywords
cysticercus - cerebellopontine angle - MRI
Introduction
Intracranial cysticercosis is the most common parasitic infection[1]. Human cysticercosis is caused by ingestion of food contaminated with the ova of
Taenia solium. Gastric juices dissolve the outer shell of the ova to release the primary larvae
or oncospheres which penetrate the mucosa and enter the bloodstream. They can lodge
in any tissue but have predilection for brain. These cysts may lodge in the subarachnoid
space and become multilocular resembling a cluster of grapes. This is known as racemose
form and may attain larger size.[2] It predominantly involves cerebral parenchyma and ventricles.[1]
[2] Its location in the cerebellopontine angle is rare in India,[3] and because of its large size and mistaken diagnosis of tubercular arachnoiditis,
it is being reported.
Case Report
A 58-year-old woman presented with headache mild to moderate in intensity radiating
from forehead to neck region with slight difficulty in walking and frequent falls.
There was no history of blurring of vision, incontinence, or memory impairment. On
examination, the patient was conscious and fundus revealed papilledema. There was
left facial upper motor neuron paresis, deep tendon jerks were brisk, and bilateral
cerebellar signs were present. Magnetic resonance imaging (MRI) was suggestive of
communicating hydrocephalus. Ventricular cerebrospinal fluid (CSF) was clear, colorless
with glucose 50 mg/dL, protein 42.2 mg/dL, and no cells. CSF was negative for acid
fast bacilli (AFB) on Ziehl-Neelsen staining. Ventriculoperitoneal shunt was placed
and her gait improved.
Three months later, she was readmitted in neurology service with history of low-grade
fever of 1-week duration and headache of 2 days duration. There was no sensory or
motor deficit. Deep tendon reflexes (DTR) were brisk. MRI scan revealed cerebellopontine
angle cystic lesion with peripheral enhancement and basal meningeal enhancement (see
[Fig. 1a, b]). ESR was 49 mm first hour Westergren. Lumbar puncture revealed protein 203 mg/dL,
glucose 56 mg/dL, and 150 cells/cu mm, 98% being lymphocytes. In view of earlier incompletely
treated tubercular lymph adenitis of retroauricular region, the patient was diagnosed
with tubercular arachnoiditis, and antitubercular (rifampicin, isoniazid, pyrazinamide,
and ethambutol) drugs were started.
Fig. 1 Axial T1W1 image hypointense lesion in left CP angle (a) contrast T1W1 image showing peripheral and meningeal enhancement, (b) 3 months later T1W1 image showing increase size of cyst, and (c) multilocular appearance on sagittal contrast FSPGR (d).
The patient was readmitted 3 months later with complaints of generalized weakness
and imbalance on walking. On examination, patient was conscious power was grade V
in all limbs, mild cerebellar signs were present on the left side, and nystagmus was
present with fast component to left side. Deep tendon jerks were brisk and plantar
were up going bilaterally. MRI revealed enlargement of the cerebellopontine angle
cystic lesion with peripheral enhancement (see [Fig. 1c, d]).
Retromastoid suboccipital craniectomy revealed thickened opaque arachnoid in the cerebellopontine
angle. Dissection of the arachnoid between fifth and seventh nerve revealed thin-walled
cyst protruding through the dissected arachnoid. It could be delivered easily and
it ruptured at the last moment of delivery discharging clear fluid. [Fig. 2] shows the operative specimen.
Fig. 2 Operative specimen of large collapsed cysticercus.
Histopathology examination of the cyst confirmed it to be cysticercus, composed of
multilocular cyst, the wall of which was folded and convoluted, without a scolex.
Postoperative serology (IgM) for Taenia solium was positive, and interferon gamma in plasma was negative for tuberculosis. The patient
was given a course of albendazole 400 mg twice daily for 10 days. The patient has
shown improvement during last 16 months. Her headache and ataxia have resolved and
she carries out activities of daily life without any difficulty.
Discussion
Intracranial cysticercosis remains a common infective lesion and has nonspecific clinical
manifestation in developing countries. Only few cases of solitary intracranial cysticercosis
involving the cerebellopontine angle have been reported.[4]
[5]
[6]
[7] Usually, the cysticerci are small lesions and cysts with largest dimension of more
than 4 to 5 cm8 are called giant cysticerci. Usually, clinical manifestation results from inflammatory
response to cyst degeneration, mass effect, obstruction of CSF pathway, or residual
scaring[9]
[10] but is related to the numbers, size, location of the lesion, and severity of the
host immune system. Contralateral trigeminal neuralgia has been reported by Revuelta
et al (1995) in ipsilateral cerebellopontine angle cysticercosis. Mural nodule on
MRI is pathognomonic of cysticercus.
In the patient, a large cystic mass was seen in cerebellopontine angle indenting the
brain stem and was misdiagnosed as a cystic form of tubercular arachnoiditis in view
of the past history of tubercular lesion from retroauricular region having been diagnosed
as tubercular though exact nature of pathology could not be verified in view of long
time elapsed since the surgery which was done at another hospital.
Multiple cyst, lobulated masses, and cystic masses have been reported in the racemose
type.[6] On MRI, these cysts have same signal intensity as that of CSF on all pulse sequences
with no enhancement postgadolinium. Ring enhancement, however, has been reported[4] and was seen by us as well. The absence of scolex and location in the subarachnoid
space are in favor of this being racemose type. The differential diagnosis of such
lesion includes epidermal cyst, arachnoid cyst, cystic schwannoma, cystic meningioma,
and tubercular arachnoiditis. Typically, epidermoid shows irregular margins and insinuates
around nerve and blood vessels; it is hypointense on T1WI, hyperintense on T2WI, and
shows restriction on diffusion-weighted images. Totally cystic nonenhancing schwannoma
may be difficult to differentiate on MRI, but widened auditory canal will clinch the
diagnosis. Cystic meningioma can be differentiated by broad-based attachment to petrous
dura, and dural tail if present can be helpful in diagnosis. Arachnoid cysts do not
enhance on contrast administration and show no restriction on diffusion-weighted images.
Enlargement of the cyst was the reason for subjecting the patient to surgery. Surgery
has an important role in the successful management of the intracranial cysticercosis
involving the cerebellopontine angle. Cysticercosis should be removed gently to avoid
its rupture.
Racemose varieties arise from the segmentation of cysticercus cellulosae with degeneration
of the scolex and are nonviable. They attain large size because in the cisternal or
subarachnoid space there is no limiting parenchymal tissue that can act as host response
for encapsulation. Degenerative stage lacks in the racemose type.[11]
Even though second CSF and radiology were suggestive of tuberculosis, enlargement
of the cystic lesion necessitated surgery which proved the diagnosis and was therapeutic
as well. To conclude, cysticercosis be considered in the differential diagnosis of
cystic lesion in the cerebellopontine angle. If the cyst enlarges on follow-up, surgery
should be done for diagnosis and for treatment.
