Synthesis 2018; 50(20): 4089-4096
DOI: 10.1055/s-0037-1610212
paper
© Georg Thieme Verlag Stuttgart · New York

Direct Oxytosylation of 8-Amidoquinolines by Koser’s Reagent: An Efficient Strategy for 5-Substituted 8-Amidoquinolines

Zubeda Begum
a  Center for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Email: [email protected]
,
G. Bhavani
a  Center for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Email: [email protected]
,
B. Sridhar
b  Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
,
Basireddy V. Subba Reddy*
a  Center for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 09 May 2018

Accepted after revision: 20 June 2018

Publication Date:
07 August 2018 (online)

 


Abstract

A metal-free remote oxytosylation of 8-amidoquinolines has been achieved using Koser’s reagent to produce 5-tosyloxy-8-amidoquinolines in good yields. This method is compatible with various functional groups present on the aromatic ring.


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Introduction of oxygen functionality on aromatic and heteroaromatic ring is a challenging task in organic synthesis.[1] Recently, a few strategies have been developed for the oxytosylation of aromatic systems through a C–H bond oxidation.[2] In recent years, 8-amidoquinolines have successfully been employed for the aromatic C–H bond functionalization.[3] On the other hand, a remote functionalization of 8-amidoquinolines have been reported with diversified reagents to generate 5-substituted 8-amidoquinolines through a C–H activation.[4] In recent years, Koser’s reagent 2 has gained importance as a versatile and effective source for oxytosylation of organic compounds.[5] Recently, Shen et al.[6] reported the iodobenzene-catalyzed synthesis of aryl sulfonate esters by the remote functionalization of aminoquinolines at room temperature using peracetic acid as oxidant. However, there have been no reports on oxytosylation of 8-amidoquinolines at C-5 position using Koser’s reagent.

Following our interest on C–H functionalization,[7] we herein report an efficient strategy for the synthesis of 5-tosyloxy-8-amidoquinolines using Koser’s reagent, which is generated in situ from PhI(OAc)2 and p-toluenesulfonic acid (p-TSA). The required precursors were prepared from 8-aminoquinoline and the corresponding carboxylic acid using EDCI and DMAP in CH2Cl2 at 0 °C under nitrogen atmosphere.[8] The Koser’s reagent was prepared from p-toluenesulfonic acid or p-toluenesulfonyl hydrazide using readily available (diacetoxyiodo)benzene (Scheme [1]).[9]

Zoom Image
Scheme 1 Preparation of Koser’s reagent

To optimize the reaction conditions, the oxytosylation of N-(quinolin-8-yl)benzamide (1a) with p-toluenesulfonic acid or p-toluenesulfonyl hydrazide was attempted in the presence of 20 mol% PhI(OAc)2 in dichloromethane (Scheme [2]).

Zoom Image
Scheme 2 Oxytosylation of N-(quinolin-8-yl)benzamide (1a)

The product 3a was isolated in low yield (20%) under these conditions (Table [1], entry 1). Therefore, the above reaction was carried out using a stoichiometric amount of PhI(OAc)2. Interestingly, the product 3a was obtained in excellent yield under the above conditions (entry 2). However, no reaction was observed in the absence of PhI(OAc)2 (entry 3). The product 3a was obtained only in 40% yield when the reaction was performed in acetonitrile (entry 4).

Table 1 Optimization of Reaction Conditions in the Formation of 3a a

Entry

PhI(OAc)2(equiv)

p-TSA (equiv)

Solvent

Time (h)

Yield (%)

1

0.2

1.2

CH2Cl2

 1.0

20

2

1.05

1.2

CH2Cl2

12

86

3

0

1.2

CH2Cl2

 6

 0

4

1.0

1.2

MeCN

12

40

a Reaction was performed in 1.5 mmol scale at 25 °C.

These initial findings encouraged us to study the scope of this methodology. This method is compatible with different 8-amidoquinolines bearing chloro-, bromo-, fluoro-, methyl-, and trifluoromethyl substituents on the aromatic ring of the carboxylic acid moiety (Scheme [3]). The substituent present on the aryl group of 8-amidoquinolines had shown significant effect on the conversion. The presence of halide or methyl group on the aryl ring gave the product in good yield. The reaction was quite successful not only with aromatic but also with heteroaromatic substrates (3k). However, the reaction was unsuccessful with amides derived from 8-aminoquinoline and carboxylic acids like 4-nitrobenzoic acid and acetic acid (3p and 3q). Similarly, the amide derived from aniline and benzoic acid also failed to give the desired product (3r). Furthermore, no desired product was obtained either with 8-aminoquinoline or with NBoc, and NCbz derivative of 8-aminoquinoline. All the products were thoroughly characterized by NMR, IR, and mass spectrometry. The reaction is highly selective and no oxytosylation was observed on the aryl ring of the carboxylic acid moiety (Scheme [3]). This method was successfully applied for a gram scale (1.2 g) synthesis of product 3d.

Zoom Image
Scheme 3 Scope of the reaction. Yield refers to pure products after chromatography.

Finally, the structure of 3a was confirmed unambiguously by a single crystal X-ray structural analysis (Figure [1]).[10]

Zoom Image
Figure 1 ORTEP diagram of 3a

In addition, a differential deprotection of both tosyl and amide groups has been achieved by merely changing the reaction conditions (Scheme [4]). Deprotection of the amide functionality was achieved to give the product 4 using HCl without affecting the tosyl group. The selective deprotection of tosyl group was accomplished to produce product 5 using NaOH in methanol (Scheme [4]).

Zoom Image
Scheme 4 Deferential deprotection of amide and tosyl groups

Mechanistically, the reaction proceeds likely through a sequential formation of intermediates A to C from 8-amidoquinoline 1a and Koser’s reagent.[11] Finally, the displacement of aryliodonium ion by tosylate anion would give the desired product 3a (Scheme [5]).

Zoom Image
Scheme 5 A plausible reaction path way

In conclusion, we have developed a novel strategy for the direct oxytosylation of 8-amidoquinolines using Koser’s reagent. The present strategy provides a rapid access to C-5 substituted 8-amidoquinolines in a single step process under mild conditions. It is totally a metal-free approach.

1H NMR spectra were recorded at 500 MHz, 300 MHz, and 400 MHz, and 13C NMR at 125 MHz, 100 MHz, and 75MHz. For 1H NMR, TMS was used as an internal standard (δ = 0) and the values are reported as follows: chemical shift, multiplicity, integration (standard abbreviations), and the coupling constants in Hz. For 13C NMR, CDCl3 (δ = 77.00) was used as internal standard and spectra were obtained with complete proton decoupling. DMSO (δ = 2.50) for 1H NMR and DMSO (δ = 39.43) for 13C NMR. Low-resolution MS and HRMS data were obtained using ESI ionization. IR spectra were recorded on an FT-IR spectrophotometer (neat) and reported in cm–1. Melting points were measured on micro melting point apparatus. Glass syringes were used to transfer solvents. Crude products were purified by column chromatography on silica gel of 60–120 or 100–200 mesh. TLC plates were visualized by exposure to UV light and/or by exposure to I2 vapors and/or by exposure to methanolic acidic solution of 2-naphthol followed by heating (<1 min) on a hot plate (∼250 °C).


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N-(Quinolin-8-yl)benzamides 1; General Procedure

To a solution of the respective carboxylic acid (6 mmol), the corresponding 8-aminoquinoline (6 mmol), and DMAP (73 mg, 0.6 mmol) in anhyd CH2Cl2 (30 mL) was added a solution of EDCI (1.38 g, 7.2 mmol) in CH2Cl2 (30 mL) through a dropping funnel at 0 °C under N2 atmosphere. The mixture was allowed to stir at r.t. for overnight. After completion, the mixture was diluted with CH2Cl2 (50 mL). The organic layer was washed with aq 1 N HCl (15 mL), followed by aq NaHCO3 (15 mL), brine (25 mL), and dried (NaSO4). The organic solvent was removed by evaporation and the residue was purified by column chromatography using EtOAc/hexane to afford the desired pure N-(quinolin-8-yl)arylamide 1.


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N-(Quinolin-8-yl)benzamide (1a)

White solid; yield: 188 mg (94%); mp 68–70 °C.

IR (neat): 3350, 3053, 1982, 1673, 1530, 1480, 1385, 1264, 1177, 1070, 825, 757, 689 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.40 (br s, 1 H), 8.93 (dd, J = 4.1, 1.4 Hz, 1 H), 8.25 (dd, J = 8.3, 1.4 Hz, 1 H), 8.10 (d, J = 7.2 Hz, 2 H), 8.02 (d, J = 9.0 Hz, 1 H), 7.51–7.67 (m, 6 H).

13C NMR (CDCl3, 100 MHz): δ = 165.3, 148.2, 138.6, 136.3, 135.0, 134.5, 131.8, 128.8, 127.9, 127.2, 121.7, 121.6, 116.5.

HRMS (EI): m/z (M + Na)+ calcd for C16H12N2ONa: 271.0842; found: 271.0868.


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4-Chloro-N-(quinolin-8-yl)benzamide (1b)

Yellow solid; yield: 186 mg (93%); mp 100–102 °C.

IR (neat): 3332, 1674, 1530, 1477, 1327, 1261, 1089, 897, 751, 662 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.6 (br s, 1 H), 8.86 (dd, J = 7.6, 1.3 Hz, 1 H), 8.78 (dd, J = 4.2, 1.6 Hz, 1 H), 8.10 (dd, J = 8.2, 1.6 Hz, 1 H), 7.96 (d, J = 8.5 Hz, 2 H), 7.38–7.56 (m, 5 H).

13C NMR (CDCl3, 100 MHz): δ = 164.1, 148.3, 138.6, 138.0, 136.3, 134.3, 133.4, 129.0, 128.6, 127.9, 127.3, 121.8, 121.7, 116.5.

HRMS (EI): m/z (M + H)+ calcd for C16H12ClN2O: 283.0632; found: 283.0639.


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2-Bromo-N-(quinolin-8-yl)benzamide (1c)

Light brown solid; yield: 178 mg (89%); mp 86–88 °C.

IR (neat): 3334, 2924, 2853, 1673, 1529, 1480. 1420, 1324, 1259, 1065, 896, 792, 653 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.66 (br s, 1 H), 8.87 (dd, J = 7.4, 1.3 Hz, 1 H), 8.82 (dd, J = 4.1, 1.5 Hz, 1 H), 8.19 (t, J = 1.8 Hz, 1 H), 8.14 (dd, J = 8.2, 1.5 Hz, 1 H), 7.95 (d, J = 7.7 Hz, 1 H), 7.67 (d, J = 7.9 Hz, 1 H), 7.50–7.57 (m, 2 H), 7.42–7.46 (m, 1 H), 7.38 (t, J = 7.9 Hz, 1 H).

13C NMR (CDCl3, 100 MHz): δ = 163.8, 148.4, 138.6, 137.0, 136.4, 134.8, 134.2, 130.6, 130.3, 127.9, 127.4, 125.6, 123.0, 122.0, 121.7, 116.7.

HRMS (EI): m/z (M)+ calcd for C16H11BrN2O: 327.0128; found: 327.0150.


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4-Methyl-N-(quinolin-8-yl)benzamide (1d)

White solid; yield: 184 mg (92%); mp 136–138 °C.

IR (neat): 3348, 2972, 1674, 1610, 1532, 1418, 1284, 1181, 1117, 944, 826, 753, 662 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.66 (br s, 1 H), 8.98 (dd, J = 7.6, 1.2 Hz, 1 H), 8.84 (dd, J = 4.4, 1.6 Hz, 1 H), 8.56 (s, 1 H), 8.09–8.14 (m, 2 H), 7.98–8.01 (m, 1 H), 7.95 (d, J = 8.5 Hz, 1 H), 7.86–7.89 (m, 1 H), 7.49–7.60 (m, 4 H), 7.41–7.44 (m, 1 H).

13C NMR (CDCl3, 125 MHz): δ = 165.4, 148.2, 142.3, 138.8, 136.3, 134.7, 132.3, 129.4, 128.8, 128.0, 127.4, 127.3, 121.6, 121.5, 116.4, 21.5.

HRMS (EI): m/z (M + H)+ calcd for C17H15N2O: 263.1178; found: 263.1184.


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3-Chloro-N-(quinolin-8-yl)benzamide (1e)

Yellow solid; yield: 186 mg (93%); mp 80–82 °C.

IR (neat): 3736, 3355, 3055, 2358, 1670, 1536, 1476, 1383, 1330, 1255, 1176, 904, 787, 762, 727, 678, 648 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.56 (br s, 1 H), 8.82 (dd, J = 7.4, 1.4 Hz, 1 H), 8.73 (dd, J = 4.2, 1.7 Hz, 1 H), 8.03 (dd, J = 8.1, 1.5 Hz, 1 H), 7.98 (t, J = 1.8 Hz, 1 H) , 7.84 (dt, J = 7.8, 1.1 Hz, 1 H), 7.32–7.50 (m, 5 H).

13C NMR (CDCl3, 125 MHz): δ = 163.7, 148.3, 138.6, 136.8, 136.3, 134.9, 134.1, 131.8, 130.0, 127.9, 127.7, 127.3, 125.1, 122.0, 121.7, 116.6.

HRMS (EI): m/z (M + H)+ calcd for C16H12ClN2O: 283.0633; found: 283.0636.


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5-Bromo-2-fluoro-N-(quinolin-8-yl)benzamide (1f)

Brown solid; yield: 178 mg (89%); mp 280–282 °C.

IR (neat): 3327, 3129, 2924, 1638, 1548, 1502, 1276, 1054, 1007, 820, 781, 656 cm–1.

1H NMR (400 MHz, CDCl3): δ = 11.06 (br s, 1 H), 8.89 (dd, J = 7.0, 1.4 Hz, 1 H), 8.81 (dd, J = 4.0, 1.3 Hz, 1 H), 8.30 (dd, J = 6.6, 2.5 Hz, 1 H), 8.11 (d, J = 8.1 Hz, 1 H), 7.47–7.49 (m, 3 H), 7.39–7.44 (m, 1 H), 7.07 (t, J = 8.8 Hz, 1 H).

13C NMR (CDCl3, 125 MHz): δ = 160.7, 159.9, 158.2, 148.5, 136.2, 136.1, 134.7, 134.4, 127.9, 127.3, 123.7, 123.6, 122.3, 121.7, 118.3, 118.0, 117.6, 117.3.

HRMS (EI): m/z (M + H)+ calcd for C16H11BrFNO: 345.0033; found: 345.0043.


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N-(Quinolin-8-yl)-2-naphthamide (1g)

Colorless solid; yield: 176 mg (88%); mp 118–120 °C.

IR (neat): 3354, 3046, 1668, 1525, 1482, 1322, 1129, 830, 771, 674 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.66 (br s, 1 H), 8.98 (dd, J = 7.6, 1.2 Hz, 1 H), 8.84 (dd, J = 4.4, 1.6 Hz, 1 H), 8.56 (s, 1 H), 8.09–8.14 (m, 2 H), 7.98–8.01 (m, 1 H), 7.95 (d, J = 8.5 Hz, 1 H), 7.86–7.89 (m, 1 H), 7.49–7.60 (m, 4 H), 7.41–7.44 (m, 1 H).

13C NMR (CDCl3, 100 MHz): δ = 165.4, 148.3, 138.8, 136.4, 134.9, 134.6, 132.7, 132.3, 129.2, 128.7, 128.0, 127.9, 127.89, 127.83, 127.5, 126.8, 123.7, 121.7.

HRMS (EI): m/z (M + H)+ calcd for C20H15N2O: 299.1178; found: 299.1181.


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N-(Quinolin-8-yl)-4-(trifluoromethyl)benzamide (1h)

White solid; yield: 180 mg (90%); mp 92–94 °C.

IR (neat): 3343, 2929, 1669, 1539, 1480, 1326, 1141, 1065, 1013, 828, 600 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.66 (br s, 1 H), 8.84 (d, J = 7.4 Hz, 1 H), 8.75 (d, J = 4.1 Hz, 1 H), 8.07 (t, J = 8.8 Hz, 3 H), 7.70 (d, J = 8.0 Hz, 2 H), 7.42–7.52 (m, 2 H), 7.34–7.39 (m, 1 H).

13C NMR (CDCl3, 125 MHz): δ = 163.7, 148.3, 138.5, 138.2, 136.3, 134.0, 133.2 (q, J C,F = 32.6 Hz), 127.8, 127.6, 127.2, 125.7, 125.7, 124.8, 122.6, 122.1, 121.7, 116.6.

HRMS (EI): m/z (M + H)+ calcd for C17H12F3N2O: 317.0896; found: 317.0884.


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N-(Quinolin-8-yl)-3,5-bis(trifluoromethyl)benzamide (1i)

Pale yellow solid; yield: 176 mg (88%); mp 156–158 °C.

IR (neat): 3334, 3062, 1677, 1545, 1487, 1376, 1276, 1189, 1119, 896, 761, 695 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.78 (br s, 1 H), 8.84–8.88 (m, 2 H), 8.48 (s, 2 H), 8.19 (dd, J = 8.3, 1.5 Hz, 1 H), 8.08 (s, 1 H), 7.56–7.60 (m, 2 H), 7.47–7.52 (m, 1 H).

13C NMR (CDCl3, 125 MHz): δ = 162.2, 148.6, 138.6, 137.2, 136.5, 133.7, 132.4 (q, J C,F = 33.6 Hz), 127.9, 127.5, 127.3, 125.32, 125.30, 125.2, 122.6, 121.9, 116.9.

HRMS (EI): m/z (M + H)+ calcd for C18H11F6N2O: 385.0770; found: 385.0775


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4-Fluoro-N-(quinolin-8-yl)benzamide (1j)

White solid; yield: 182 mg (91%); mp 89–90 °C.

IR (neat): 3447, 3351, 3061,1666, 1541, 1506, 1485, 1330, 1224, 1165, 1012, 822, 757, 649 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.66 (br s, 1 H), 8.89 (dd, J = 7.4, 1.3 Hz, 1 H), 8.82 (dd, J = 4.1, 1.6 Hz, 1 H), 8.15 (dd, J = 8.2, 1.6 Hz, 1 H), 8.05–8.10 (m, 2 H), 7.50–7.59 (m, 2 H), 7.43–7.46 (m, 1 H), 7.20 (t, J = 8.6 Hz, 2 H).

13C NMR (CDCl3, 100 MHz): δ = 166.2, 164.2, 163.7, 148.3, 138.7, 136.4, 134.4, 131.3, 129.7, 129.6, 128.0, 127.4, 121.8, 121.7, 116.5, 115.9, 115.7.

HRMS (EI): m/z (M + H)+ calcd for C16H12FN2O: 267.0928; found: 267.0935.


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N-(Quinolin-8-yl)thiophene-2-carboxamide (1k)

Pale yellow solid; yield: 150 mg (75%); mp 88–90 °C.

IR (neat): 3346, 3073, 2924, 1651, 1533, 1483, 1355, 1267, 1115, 1055, 819, 731, 643 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.58 (br s, 1 H), 8.82–8.85 (m, 2 H), 8.16 (dd, J = 8.3, 1.7 Hz, 1 H), 7.83 (dd, J = 3.7, 1.1 Hz, 1 H), 7.50–7.59 (m, 3 H), 7.44–7.48 (m, 1 H), 7.16–7.19 (m, 1 H).

13C NMR (CDCl3, 100 MHz): δ = 160.0, 148.3, 140.1, 138.5, 136.3, 134.3, 130.9, 128.4, 127.99, 127.90, 127.4, 121.75, 121.71, 116.5.

HRMS (EI): m/z (M + H)+ calcd for C14H11N2OS: 255.0586; found: 255.0593.


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N-(Quinolin-8-yl)-[1,1′-biphenyl]-4-carboxamide (1l)

White solid; yield: 170 mg (85%); mp 139–141 °C.

IR (neat): 3359, 3026, 2360, 1664, 1536, 1483, 1386, 1327, 1258, 1177, 1002, 895, 824, 743, 643 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.77 (br s, 1 H), 8.95 (d, J = 7.6 Hz, 1 H), 8.84 (d, J = 3.9 Hz, 1 H), 8.14 (d, J = 8.2 Hz, 3 H), 7.74 (d, J = 8.0 Hz, 2 H), 7.64 (d, J = 7.4 Hz, 2 H), 7.36–7.60 (m, 6 H).

13C NMR (CDCl3, 100 MHz): δ = 165.1, 148.3, 144.6, 140.0, 138.8, 136.4, 134.6, 133.8, 129.0, 128.1, 128.0, 127.8, 127.5, 127.4, 127.2, 121.7, 116.6.

HRMS (EI): m/z (M + H)+ calcd for C22H17N2O: 325.1335; found: 325.1366.


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3-Bromo-N-(quinolin-8-yl)benzamide (1m)

Light brown solid; yield: 178 mg (89%); mp 88–90 °C.

IR (neat): 3421, 3333, 2924, 1673, 1526, 1476, 1419, 1325, 1256, 1062, 901, 828, 733 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.65 (br s, 1 H), 8.88 (dd, J = 7.4, 1.5 Hz, 1 H), 8.83 (dd, J = 4.2, 1.6 Hz, 1 H), 8.19 (t, J = 1.8 Hz, 1 H), 8.15 (dd, J = 8.2, 1.5 Hz, 1 H), 7.96 (dt, J = 7.9, 1.0 Hz, 1 H), 7.68 (d, J = 7.9 Hz, 1 H), 7.51–7.59 (m, 2 H), 7.43–7.48 (m, 1 H), 7.39 (t, J = 7.7 Hz, 1 H).

13C NMR (CDCl3, 100 MHz): δ = 163.6, 148.3, 138.5, 136.9, 136.3, 134.7, 134.1, 130.6, 130.2, 127.9, 127.3, 125.6, 123.0, 122.0, 121.7, 116.6.

HRMS (EI): m/z (M)+ calcd for C16H11BrN2O: 327.0128; found: 327.0129.


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N-(2-Methylquinolin-8-yl)benzamide (1n)

White solid; yield: 299 mg (92%); mp 88–90 °C.

IR (neat): 3331, 3025, 1668, 1541, 1467, 833, 693 cm–1.

1H NMR (400 MHz, CDCl3): δ = 2.77 (s, 3 H), 7.34 (d, J = 8.4 Hz, 1 H), 7.47–7.59 (m, 5 H), 8.04–8.10 (m, 3 H), 8.90 (dd, J = 7.0, 1.9 Hz, 1 H), 10.81 (s, 1 H).

13C NMR (100.6 MHz, CDCl3): δ = 165.3, 157.2, 138.1, 136.5, 135.3, 133.9, 131.7, 128.8, 127.2, 126.4, 126.1, 122.4, 121.4, 116.5, 25.4.

HRMS (EI): m/z (M + H)+ calcd for C17H15N2O: 263.1184; found: 263.1169.


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N-[2-(Hydroxymethyl)quinolin-8-yl]benzamide (1o)

Colorless solid; yield: 290 mg (85%); mp 116–118 °C.

IR (neat): 3444, 3332, 3049, 2929, 1646, 1542, 1408, 1065, 693 cm–1.

1H NMR (400 MHz, CD3OD): δ = 4.96 (s, 2 H), 7.56–7.71 (m, 6 H), 8.09 (d, J = 7.4 Hz, 2 H), 8.34 (d, J = 8.5 Hz, 1 H), 8.80 (d, J = 7.5 Hz, 1 H).

13C NMR (100.6 MHz, CD3OD): δ = 166.0, 160.0, 137.8, 136.9, 134.7, 133.8, 131.8, 128.6, 127.2, 126.9, 126.2, 122.0, 119.4, 116.7, 65.0.

HRMS (EI): m/z (M + H)+ calcd for C17H15N2O2: 279.1134; found: 279.1115.


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4-Nitro-N-(quinolin-8-yl)benzamide (1p)
Yellow solid; yield: 120 mg (60%); mp 154–156 °C.

IR (neat): 3444, 3352, 3102, 2924, 2853, 1677, 1517, 1479, 1340, 1256, 1107, 824, 708 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.79 (br s, 1 H), 8.89 (dd, J = 5.9, 2.9 Hz, 1 H), 8.86 (dd, J = 4.2, 1.7 Hz, 1 H), 8.36 (d, J = 8.8 Hz, 2 H), 8.20 (d, J = 8.6 Hz, 3 H), 7.58–7.61 (m, 2 H), 7.48–7.53 (m, 1 H).

13C NMR (CDCl3, 100 MHz): δ = 163.1, 149.7, 148.5, 140.5, 138.6, 136.5, 133.9, 128.4, 128.0, 127.4, 124.0, 122.5, 121.9, 116.9.

HRMS (EI): m/z calcd for C16H12N3O3 (M + H)+: 294.0873; found: 294.0880.


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N-(Quinolin-8-yl)acetamide (1q)

Colorless solid; yield: 158 mg (79%); mp 76–78 °C.

IR (neat): 3286, 2924, 1665, 1533, 1481, 1422, 1377, 1320, 1257, 1092, 1004, 824, 789, 691 cm–1.

1HNMR (500 MHz, CDCl3): δ = 9.78 (br s, 1 H), 8.79 (dd, J = 4.2, 1.7 Hz, 1 H), 8.76 (dd, J = 7.3, 1.2 Hz, 1 H), 8.14 (dd, J = 8.1, 1.5 Hz, 1 H), 7.41–7.55 (m, 3 H), 2.35 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 168.8, 148.1, 138.2, 136.4, 134.5, 127.9, 127.4, 121.6, 121.4, 116.4.

HRMS (EI): m/z (M + Na)+ calcd for C11H10N2ONa: 209.0685; found: 209.0681.


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Oxytosylation; General Procedure

To a solution of PhI(OAc)2 (509 mg, 1.58 mmol) in CH2Cl2 (10 mL) was added TsOH·H2O (342 mg, 1.8 mmol). The resulting suspension was stirred for 15 min at r.t. and then a solution of 8-amidoquinoline 1b (423 mg, 1.5 mmol) in CH2Cl2 (5 mL) was added rapidly. The progress of the reaction was monitored by TLC. Upon completion, the mixture was diluted with H2O and extracted with CH2Cl2 and the combined organic extracts were concentrateds under reduced pressure. The resulting­ residue was purified by column chromatography using EtOAc­/hexane to afford the pure tosyloxyamide 3b.


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8-Benzamidoquinolin-5-yl 4-Methylbenzenesulfonate (3a)

White solid; yield: 156 mg (86%); mp 174–176 °C.

IR (neat): 3353, 2922, 1673, 1529, 1485, 1369, 1182, 1002, 859, 808, 708, 662, 639 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.59 (br s, 1 H), 8.86 (dd, J = 4.1, 1.5 Hz, 1 H), 8.79 (d, J = 8.6 Hz, 1 H), 8.41 (dd, J = 8.4, 1.5 Hz, 1 H), 8.05 (dd, J = 8.3, 1.2 Hz, 2 H), 7.77 (d, J = 8.3 Hz, 2 H), 7.52–7.61 (m, 3 H), 7.50 (dd, J = 8.4, 5.1 Hz, 1 H), 7.33 (d, J = 7.9 Hz, 2 H), 7.03 (d, J = 8.5 Hz, 1 H), 2.46 (s, 3 H).

13C NMR (CDCl3, 100 MHz): δ = 165.5, 149.0, 145.8, 139.6, 138.9, 134.8, 133.9, 132.0, 131.4, 130.0, 128.9, 128.7, 127.3, 123.0, 122.2, 119.9, 115.3, 21.7.

HRMS (EI): m/z (M + H)+ calcd for C23H19N2O4S: 419.1060; found: 419.1095.


#

8-(4-Chlorobenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3b)

White solid; yield: 152 mg (84%); mp 106–108 °C.

IR (neat): 3346, 2922, 1674, 1531, 1482, 1372, 1181, 1090, 1002, 856, 754, 664 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.60 (br s, 1 H), 8.85 (dd, J = 4.2, 1.2 Hz, 1 H), 8.75 (d, J = 8.6 Hz, 1 H), 8.39 (dd, J = 8.5, 1.2 Hz, 1 H), 7.98 (d, J = 8.3 Hz, 2 H), 7.77 (d, J = 8.2 Hz, 2 H), 7.48–7.52 (m, 3 H), 7.32 (d, J = 8.2 Hz, 2 H), 7.03 (d, J = 8.5 Hz, 1 H), 2.45 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 164.3, 149.0, 145.9, 139.8, 138.8, 138.4, 133.6, 133.1, 132.0, 131.5, 130.0, 129.1, 128.7, 123.0, 122.3, 119.9, 115.3, 21.7.

HRMS (EI): m/z (M + H)+ calcd for C23H18ClN2O4S: 453.0670; found: 453.0678.


#

8-(2-Bromobenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3c)

White solid; yield: 153 mg (85%); mp 138–140 °C.

IR (neat): 3334, 3070, 2921, 1664, 1531, 1371, 1170, 1047, 1002, 851, 799, 668 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.56 (br s, 1 H), 8.84 (dd, J = 4.1, 1.6 Hz, 1 H), 8.74 (d, J = 8.5 Hz, 1 H), 8.36 (dd, J = 8.3, 1.0 Hz, 1 H), 8.16 (s, 1 H), 7.93 (d, J = 7.6 Hz, 1 H), 7.75 (d, J = 8.2 Hz, 2 H), 7.68 (d, J = 7.9 Hz, 1 H), 7.50 (dd, J = 8.4, 5.1 Hz, 1 H), 7.40 (t, J = 7.7 Hz, 1 H), 7.31 (d, J = 8.0 Hz, 2 H), 7.04 (d, J = 8.5 Hz, 1 H), 2.44 (s, 3 H).

13C NMR (CDCl3, 100 MHz): δ = 163.8, 149.1, 145.9, 139.8, 138.8, 136.7, 135.0, 133.4, 132.0, 131.3, 130.6, 130.3, 130.0, 128.6, 125.6, 123.1, 122.9, 122.3, 119.8, 115.4, 21.7.

HRMS (EI): m/z (M)+ calcd for C23H17BrN2O4S: 497.0165; found: 497.0188.


#

8-(4-Methylbenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3d)

White solid; yield: 156 mg (86%); mp 122–124 °C.

IR (neat): 3362, 3926, 1671, 1530, 1468, 1370, 1184, 1002, 857, 735, 659, 537 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.73 (br s, 1 H), 8.85 (dd, J = 4.1, 1.5 Hz, 1 H), 8.78 (d, J = 8.6 Hz, 1 H), 8.39 (dd, J = 8.4, 1.5 Hz, 1 H), 7.94 (d, J = 8.1 Hz, 2 H), 7.76 (d, J = 8.3 Hz, 2 H), 7.49 (dd, J = 8.5, 4.2 Hz, 1 H), 7.33 (t, J = 8.3 Hz, 4 H), 7.02 (d, J = 8.5 Hz, 1 H), 2.46 (s, 6 H).

13C NMR (CDCl3, 100 MHz): δ = 165.4, 148.9, 145.8, 142.6, 139.5, 138.8, 134.0, 132.0, 131.9, 131.3, 130.0, 129.5, 128.7, 127.3, 123.0, 122.2, 119.9, 115.1, 21.7, 21.5.

HRMS (EI): m/z (M + Na)+ calcd for C24H20N2O4SNa: 455.1605; found: 455.1620.


#

8-(3-Chlorobenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3e)

White solid; yield: 152 mg (84%); mp 146–148 °C.

IR (neat): 3333, 3077, 2920, 2363, 1666, 1531, 1370, 1170, 1002, 851, 799, 718, 660 cm–1.

1H NMR (500 MHz, CDCl3): δ = 10.59 (br s, 1 H), 8.86 (dd, J = 4.2, 1.6 Hz, 1 H), 8.75 (d, J = 8.5 Hz, 1 H), 8.39 (dd, J = 8.5, 1.6 Hz, 1 H), 8.02 (t, J = 1.8 Hz, 1 H), 7.90 (d, J = 8.0 Hz, 1 H), 7.76 (d, J = 8.3 Hz, 2 H), 7.55 (d, J = 8.0 Hz, 1 H), 7.45–7.52 (m, 2 H), 7.33 (d, J = 8.0 Hz, 2 H), 7.04 (d, J = 8.5 Hz, 1 H), 2.46 (s, 3 H).

13C NMR (CDCl3, 100 MHz): δ = 164.0, 149.1, 145.9, 139.8, 138.8, 136.5, 135.1, 133.5, 132.1, 132.0, 131.4, 130.1, 130.0, 128.6, 127.7, 125.2, 123.0, 122.3, 119.9, 115.4, 21.7.

HRMS (EI): m/z (M + H)+ calcd for C23H18ClN2O4S: 453.0670; found: 453.0676.


#

8-(2-Bromo-5-fluorobenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3f)

Light brown solid; yield: 138 mg (76%); mp 120–122 °C.

IR (neat): 3449, 3334, 2923, 2853, 1669, 1540, 1468, 1398, 1366, 1260, 1171, 1042, 995, 853, 788, 661 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.73 (br s, 1 H), 8.86 (dd, J = 4.1, 1.3 Hz, 1 H) , 8.79 (d, J = 8.5 Hz, 1 H), 8.38 (dd, J = 8.4, 1.3 Hz, 1 H), 8.31 (dd, J = 6.7, 2.5 Hz, 1 H), 7.77 (d, J = 8.3 Hz, 2 H), 7.61–7.66 (m, 1 H), 7.49 (dd, J = 8.5, 4.1 Hz, 1 H), 7.33 (d, J = 8.0 Hz, 2 H), 7.14 (dd, J = 11.0, 8.8 Hz, 1 H),7.06 (d, J = 8.5 Hz, 1 H), 2.45 (s, 3 H).

13C NMR (CDCl3, 100 MHz): δ = 160.7, 160.1, 158.2, 149.2, 145.8, 140.1, 138.9, 136.59, 136.5, 134.7, 133.8, 132.0, 131.3, 130.0, 128.6, 123.5, 123.3, 122.9, 122.3, 119.8, 118.4, 118.1, 117.7, 116.1, 21.7.

HRMS (EI): m/z (M)+ calcd for C23H16BrFN2O4S: 515.0071; found: 515.0088.


#

8-(2-Naphthamido)quinolin-5-yl 4-Methylbenzenesulfonate (3g)

White solid; yield: 145 mg (80%); mp 126–128 °C. 

IR (neat): 3358, 2922, 1667, 1529, 1488, 1367, 1182, 1048, 1005, 857, 730, 657 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.73 (br s, 1 H), 8.88 (dd, J = 4.1, 1.4 Hz, 1 H), 8.84 (d, J = 8.5 Hz, 1 H), 8.55 (s, 1 H), 8.40 (dd, J = 8.5, 1.5 Hz, 1 H), 7.96–8.10 (m, 3 H), 7.91 (d, J = 8.8 Hz, 1 H), 7.77 (d, J = 8.3 Hz, 2 H), 7.56–7.61 (m, 2 H), 7.50 (dd, J = 8.5, 4.1 Hz, 1 H), 7.32 (d, J = 8.1 Hz, 2 H), 7.06 (d, J = 8.6 Hz, 1 H), 2.46 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 165.5, 149.0, 145.8, 139.6, 138.9, 135.0, 133.9, 132.7, 132.09, 132.01, 131.4, 130.0, 129.2, 128.8, 128.7, 128.0, 127.8, 126.9, 123.6, 123.0, 122.2, 119.9, 115.3, 21.7.

HRMS (EI): m/z (M)+ calcd for C27H20N2O4S: 469.1217; found: 469.1235.


#

8-[4-(Trifluoromethyl)benzamido]quinolin-5-yl 4-Methylbenzenesulfonate (3h)

White solid; yield: 126 mg (70%); mp 132–134 °C.

IR (neat): 3355, 1678, 1532, 1487, 1327, 1186, 1065, 1002, 858, 737, 660 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.66 (br s, 1 H), 8.85 (d, J = 3.9 Hz, 1 H), 8.76 (d, J = 8.5 Hz, 1 H), 8.40 (d, J = 8.4 Hz, 1 H), 8.15 (d, J = 8.0 Hz, 2 H), 7.75–7.83 (m, 4 H), 7.50 (dd, J = 8.4, 4.1 Hz, 1 H), 7.30–7.36 (m, 2 H), 7.05 (d, J = 8.5 Hz, 1 H), 2.46 (s, 3 H).

13C NMR (CDCl3, 100 MHz): δ = 164.0, 149.1, 145.9, 140.0, 138.8, 138.0, 133.6 (q, J C,F = 33.6 Hz), 133.4, 132.0, 131.5, 130.0, 128.6, 127.7, 125.98, 125.94, 123.0, 122.4, 119.9, 115.5, 21.7.

HRMS (EI): m/z (M + H)+ calcd for C24H18F3N2O4S: 487.0934; found: 487.0939.


#

8-[3,5-Bis(trifluoromethyl)benzamido]quinolin-5-yl 4-Methylbenzenesulfonate (3i)

White solid; yield: 130 mg (72%); mp 132–134 °C.

IR (neat): 3285, 3063, 2927, 1678, 1541, 1366, 1280, 1132, 1047, 852, 796, 684 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.73 (br s, 1 H), 8.86 (dd, J = 4.1, 1.3 Hz, 1 H), 8.79 (d, J = 8.5 Hz, 1 H), 8.38 (dd, J = 8.4, 1.3 Hz, 1 H), 8.31 (dd, J = 6.7, 2.5 Hz, 1 H), 7.77 (d, J = 8.3 Hz, 2 H), 7.61–7.66 (m, 1 H), 7.49 (dd, J = 8.5, 4.1 Hz, 1 H), 7.33 (d, J = 8.0 Hz, 2 H), 7.34 (d, J = 8.5 Hz, 2 H), 7.09 (d, J = 8.5 Hz, 1 H), 2.46 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 162.4, 149.3, 145.9, 140.3, 138.8, 136.9, 132.9, 132.7, 132.4, 132.1, 132.0, 131.6, 130.0, 128.6, 127.5, 125.5, 124.0, 123.1, 122.5, 121.8, 119.8, 115.9, 21.7.

HRMS (EI): m/z (M + Na)+ calcd for C25H17F6N2O4SNa: 555.0808; found: 555.0846.


#

8-(4-Fluorobenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3j)

White solid; yield: 148 mg (82%); mp 182–184 °C.

IR (neat): 3349, 3072, 2923, 1674, 1598, 1532, 1485, 1372, 1328, 1233, 1182, 1000, 854, 736, 662 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.6 (br s, 1 H), 8.86 (dd, J = 4.2, 1.5 Hz, 1 H), 8.76 (d, J = 8.5 Hz, 1 H), 8.41 (dd, J = 8.5, 1.5 Hz, 1 H), 8.04–8.09 (m, 2 H), 7.77 (d, J = 8.3 Hz, 2 H), 7.50 (dd, J = 8.4, 5.1 Hz, 1 H), 7.33 (d, J = 8.0 Hz, 2 H), 7.23 (t, J = 8.5 Hz, 2 H), 7.03 (d, J = 8.6 Hz, 1 H), 2.45 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 166.1, 164.1, 149.0, 145.8, 139.7, 138.8, 133.7, 132.0, 131.5, 131.02, 131.00, 130.0, 129.7, 129.6, 128.7, 123.0, 122.3, 119.9, 116.0, 115.9, 115.3, 21.7.

HRMS (EI): m/z (M + H)+ calcd for C23H18FN2O4S: 437.0966; found: 437.0974.


#

8-(Thiophene-2-carboxamido)quinolin-5-yl 4-Methylbenzenesulfonate (3k)

White solid; yield: 146 mg (81%); mp 130–132 °C.

IR (neat): 3339, 3072, 2921, 1657, 1534, 1487, 1369, 1191, 1094, 994, 848, 720, 668 cm–1.

1H NMR (500 MHz,CDCl3): δ = 10.48 (br s, 1 H), 8.85 (dd, J = 2.8, 1.3 Hz, 1 H), 8.68 (d, J = 8.5 Hz, 1 H), 8.38 (d, J = 8.3 Hz, 1 H), 7.81 (dd, J = 2.4, 1.0 Hz, 1 H), 7.75 (d, J = 8.2 Hz, 2 H), 7.59 (d, J = 4.8 Hz, 1 H), 7.47–7.51 (m, 1 H), 7.32 (d, J = 8.0 Hz, 2 H), 7.18 (t, J = 4.2 Hz, 1 H), 7.02 (d, J = 8.5 Hz, 1 H), 2.45 (s, 3 H).

13C NMR (CDCl3, 100 MHz): δ = 160.0, 149.0, 145.8, 139.6, 138.6, 133.6, 132.0, 131.4, 131.2, 130.0, 128.6, 128.3, 127.9, 123.0, 122.2, 119.9, 115.2, 21.7.

HRMS (EI): m/z (M + H)+ calcd for C21H17N2O4S2: 425.0624; found: 425.0644.


#

8-([1,1′-Biphenyl]-4-ylcarboxamido)quinolin-5-yl 4-Methylbenzenesulfonate (3l)

White solid; yield: 136 mg (75%); mp 134–136 °C.

IR (neat): 3427, 3355, 2922, 2853, 1669, 1530, 1485, 1345, 1183, 1100, 997, 843, 789, 676 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.7 (br s, 1 H), 8.88 (dd, J = 4.0, 1.2 Hz, 1 H), 8.81 (d, J = 8.5 Hz, 1 H), 8.41 (dd, J = 8.4, 1.3 Hz, 1 H), 8.13 (d, J = 8.3 Hz, 2 H), 7.78 (d, J = 7.7 Hz, 4 H), 7.66 (d, J = 7.2 Hz, 2 H), 7.46–7.54 (m, 3 H), 7.39–7.44 (m, 1 H), 7.33 (d, J = 8.0 Hz, 2 H), 7.04 (d, J = 8.5 Hz, 1 H), 2.46 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 165.2, 149.0, 145.8, 144.9, 139.9, 139.6, 138.9, 133.9, 133.4, 132.1, 131.4, 130.0, 129.0, 128.7, 128.1, 127.8, 127.5, 127.2, 123.0, 122.2, 119.9, 115.3, 21.7.

HRMS (EI): m/z (M + H)+ calcd for C29H23N2O4S: 495.1373; found: 495.1375.


#

8-(3-Bromobenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3m)

Colorless solid; yield: 153 mg (85%); mp 106–108 °C.

IR (neat): 3426, 3334, 3068, 2924, 2661, 2550, 1688, 1531, 1481, 1371, 1306, 1168, 1046, 940, 804, 744 cm–1.

1H NMR (400 MHz, CDCl3): δ = 10.58 (br s, 1 H), 8.87 (d, J = 4.0 Hz, 1 H), 8.74 (d, J = 8.5 Hz, 1 H), 8.40 (d, J = 8.4 Hz, 1 H), 8.18 (s, 1 H), 7.95 (d, J = 7.7 Hz, 1 H), 7.76 (d, J = 8.1 Hz, 2 H), 7.71 (d, J = 7.7 Hz, 1 H), 7.51 (dd, J = 8.4, 4.1 Hz, 1 H), 7.42 (t, J = 7.8 Hz, 1 H) , 7.33 (d, J = 8.0 Hz, 2 H), 7.04 (d, J = 8.5 Hz, 1 H), 2.45 (s, 3 H).

13C NMR (CDCl3, 100.6 MHz): δ = 163.9, 149.1, 145.9, 139.9, 138.8, 136.7, 136.6, 135.0, 133.4, 133.1, 132.0, 131.4, 130.6, 130.4, 130.0, 128.6, 125.6, 123.1, 123.0, 122.3, 119.8, 115.5, 21.7.

HRMS (EI): m/z (M)+ calcd for C23H17BrN2O4S: 497.0165; found: 497.0180.


#

8-Benzamido-2-methylquinolin-5-yl 4-Methylbenzenesulfonate (3n)

Colorless solid; yield: 220 mg (89%); mp 184–186 °C.

IR (neat): 3340, 3055, 2921, 1668, 1531, 1367, 1183, 1024, 819, 631 cm–1.

1H NMR (400 MHz, CDCl3): δ = 2.46 (s, 3 H), 2.76 (s, 3 H), 6.92 (d, J = 8.5 Hz, 1 H), 7.32 (d, J = 8.6 Hz, 2 H), 7.37 (d, J = 8.6 Hz, 1 H), 7.52–7.63 (m, 3 H), 7.76 (d, J = 8.3 Hz, 2 H), 8.04 (d, J = 6.6 Hz, 2 H), 8.29 (d, J = 8.5 Hz, 1 H), 8.74 (d, J = 8.5 Hz, 1 H), 10.74 (s, 1 H).

13C NMR (100.6 MHz, CDCl3): δ = 165.4, 158.2, 145.8, 139.8, 138.4, 134.9, 133.2, 132.08, 132.02, 131.48, 129.98, 128.92, 128.7, 127.2, 123.1, 121.1, 118.8, 115.2, 25.3, 21.8.

HRMS (EI): m/z (M + H)+ calcd for C24H21N2O4S: 433.1222; found: 433.1187.


#

8-Benzamido-2-(hydroxymethyl)quinolin-5-yl 4-Methylbenzenesulfonate (3o)

Viscous liquid; yield: 192 mg (80%).

IR (neat): 2923, 2853, 1742, 1460, 1376, 720 cm–1.

1H NMR (400 MHz, CDCl3): δ = 2.47 (s, 3 H), 5.00 (s, 2 H), 7.00 (d, J = 8.6 Hz, 1 H), 7.34 (d, J = 7.9 Hz, 2 H), 7.51–7.58 (m, 4 H), 7.77 (d, J = 8.4 Hz, 2 H), 8.00 (d, J = 8.3 Hz, 2 H), 8.43 (d, J = 8.6 Hz, 1 H), 8.80 (d, J = 8.6 Hz, 1 H), 10.39 (s, 1 H).

13C NMR (100.6 MHz, CDCl3): δ = 165.4, 159.2, 145.9, 134.8, 133.2, 132.5, 132.2, 130.0, 129.0, 128.7, 127.3, 127.1, 122.3, 119.8, 119.6, 116.1, 65.1, 21.8.

HRMS (EI): m/z (M + H)+ calcd for C24H21N2O5S: 449.1171; found: 449.1145.


#

Gram-Scale Synthesis of 8-(4-Methylbenzamido)quinolin-5-yl 4-Methylbenzenesulfonate (3d)

To a solution of PhI(OAc)2 (1.54 g, 4.78 mmol, 1.05 equiv) in CH2Cl2 (10 mL) was added TsOH·H2O (1.04 mg, 5.4 mmol, 1.2 equiv) and the resulting suspension was stirred for 5 min at r.t. Then, a solution of 4-methyl-N-(quinolin-8-yl)benzamide (1d; 1.2 g, 4.58 mmol, 1 equiv) in CH2Cl2 (20 mL) was added rapidly to the above suspension. The progress of the reaction was monitored by TLC. Upon completion, the mixture was diluted with CH2Cl2 (30 mL) and H2O (20 mL), and the aqueous layer was extracted with CH2Cl2 (3 × 20 mL). The combined organic layers were dried (Na2SO4). The solvent was removed by evaporation and the residue was purified by flash chromatography to give the product 3d as a white solid; yield: 1.6 g (3.7 mmol, 81%).


#

Deprotection of the Amide Functionality; 8-Aminoquinolin-5-yl 4-Methylbenzenesulfonate (4)

A solution of 8-(4-methylbenzamido)quinolin-5-yl 4-methylbenzenesulfonate (3d; 500 mg, 1.16 mmol) in aq 2 M HCl (20 mL) was heated under reflux for 3 h. The progress of the reaction was monitored by TLC. After complete conversion, the mixture was quenched with aq NaHCO3 and diluted with CH2Cl2 (30 mL). The organic layer was washed with H2O (20 mL) and the aqueous layer was extracted with CH2Cl2 (3 × 20 mL). The combined organic layers were dried (Na2SO4). Removal of the solvent followed by purification on silica gel afforded the product 4 as a brown solid; yield: 90 mg (80%); mp 118–120 °C.

IR (neat): 3488, 3385, 2923, 1592, 1478, 1357, 1171, 1044, 849, 789, 660 cm–1.

1H NMR (400 MHz, CDCl3): δ = 8.72 (dd, J = 4.1, 1.4 Hz, 1 H), 8.15 (dd, J = 8.5, 1.5 Hz, 1 H), 7.73 (d, J = 8.3 Hz, 1 H), 7.33 (dd, J = 8.5, 4.1 Hz, 1 H), 7.27 (d, J = 7.9 Hz, 2 H), 6.95 (d, J = 8.3 Hz, 1 H), 6.70 (d, J = 8.3 Hz, 1 H), 2.42 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 147.9, 145.4, 143.3, 137.8, 135.3, 132.4, 130.5, 129.7, 128.6, 123.3, 121.8, 120.4, 107.8, 21.7.

MS (ESI): m/z = 314 (M + Na)+.


#

Deprotection of the Tosyl Group; N-(5-Hydroxyquinolin-8-yl)-4-methylbenzamide (5)

To a stirred solution of 8-(4-methylbenzamido)quinolin-5-yl 4-methylbenzenesulfonate (3d; 500 mg, 1.16 mmol) in anhyd MeOH (15 mL) was added NaOH (51 mg, 1.3 mmol) and heated to reflux for 1 h. The progress of the reaction was monitored by TLC. Upon completion, MeOH was removed under reduced pressure. The mixture was diluted with CH2Cl2 (30 mL). The organic layer was washed with H2O (20 mL) and the aqueous layer was extracted with CH2Cl2 (3 × 20 mL). The combined organic layers were dried (Na2SO4) The solvent was removed by evaporation and the residue was purified by flash chromatography to give the product 5 as a white solid; yield: 100 mg (84%); mp 214–216 °C.

IR (neat): 3328, 1644, 1548, 1503, 1283, 1189, 1010, 740, 664 cm–1.

1H NMR (500 MHz, CDCl3): δ = 9.19 (br s, 1 H), 9.14 (s, 1 H), 7.67 (d, J = 3.0 Hz, 1 H), 7.36 (d, J = 8.2 Hz, 2 H), 6.67 (d, J = 7.9 Hz, 2 H), 6.33 (dd, J = 8.2, 4.1 Hz, 1 H), 6.14 (d, J = 7.7 Hz, 2 H), 5.74 (d, J = 8.2 Hz, 1 H), 1.20 (s, 3 H).

13C NMR (CDCl3, 125 MHz): δ = 162.4, 147.2, 147.0, 140.1, 137.5, 130.3, 129.8, 127.6, 125.1, 124.5, 118.9, 118.0, 115.8, 106.3, 19.4.

HRMS (EI): m/z (M + H)+ calcd for C17H15N2O2: 279.1128; found: 279.1161.


#
#

Acknowledgment

Z.B. thanks CSIR, New Delhi for the award of a fellowship.

Supporting Information

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    • 3b Ye X. Petersen JL. Shi X. Chem. Commun. 2015; 51: 7863
    • 3c Reddy VP. Qiu R. Iwasaki T. Kambe N. Org. Biomol. Chem. 2015; 13: 6803
    • 3d Liu J. Zhuang S. Gui Q. Chen X. Wang W. Ten Z. Chem. Commun. 2015; 51: 6418
    • 3e Shang R. Ilies L. Nakamura E. J. Am. Chem. Soc. 2015; 137: 7660
    • 3f Whiteoak CJ. Planas O. Company A. Ribas X. Adv. Synth. Catal. 2016; 358: 1679
    • 3g Dou Y. Xie Z. Sun Z. Fang H. Shen C. Zhang P. ChemCatChem 2016; 8: 3570
    • 3h Liang S. Manolikakes G. Adv. Synth. Catal. 2016; 358: 2371
    • 3i Chen H. Li P. Wang M. Wang L. Org. Lett. 2016; 18: 4794
    • 3j Arockiam PA. Guillemard L. Delord JW. Adv. Synth. Catal. 2017; 359: 2571
    • 3k Li JM. Wang YH. Yu Y. Wu RB. Weng J. Lu G. ACS Catal. 2017; 7: 2661
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    • 4d Liu X. Wu Z. Luo X. He Y. Zhou X. Fan Y. Huang G. RSC Adv. 2016; 6: 71485 
  • 5 Koser GF. Relenyi AG. Kalos AN. Rebrovic L. Wettach RH. J. Org. Chem. 1982; 47: 2487
  • 6 Shen C. Yang M. Xu J. Chen C. Zheng K. Shen J. Zhang P. RSC Adv. 2017; 7: 49436
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    • 9d Tuncay A. Dustman JA. Fisher G. Tuncay CI. Tetrahedron Lett. 1992; 33: 7647
  • 10 CCDC 1553346 contains supplementary crystallographic data for the structure 3a. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/getstructures.
    • 11a Basdevant B. Legault CY. Org. Lett. 2015; 17: 4918
    • 11b Carreras V. Sandtorv AH. Stuart DR. J. Org. Chem. 2017; 82: 1279

  • References

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  • 2 John OR. S. Killeen NM. Knowles DA. Yau SC. Bagley MC. Tomkinson NC. O. Org. Lett. 2007; 9: 4009
    • 3a Yan Q. Chen Z. Yu W. Yin H. Liu Z. Zhang Y. Org. Lett. 2015; 17: 2482
    • 3b Ye X. Petersen JL. Shi X. Chem. Commun. 2015; 51: 7863
    • 3c Reddy VP. Qiu R. Iwasaki T. Kambe N. Org. Biomol. Chem. 2015; 13: 6803
    • 3d Liu J. Zhuang S. Gui Q. Chen X. Wang W. Ten Z. Chem. Commun. 2015; 51: 6418
    • 3e Shang R. Ilies L. Nakamura E. J. Am. Chem. Soc. 2015; 137: 7660
    • 3f Whiteoak CJ. Planas O. Company A. Ribas X. Adv. Synth. Catal. 2016; 358: 1679
    • 3g Dou Y. Xie Z. Sun Z. Fang H. Shen C. Zhang P. ChemCatChem 2016; 8: 3570
    • 3h Liang S. Manolikakes G. Adv. Synth. Catal. 2016; 358: 2371
    • 3i Chen H. Li P. Wang M. Wang L. Org. Lett. 2016; 18: 4794
    • 3j Arockiam PA. Guillemard L. Delord JW. Adv. Synth. Catal. 2017; 359: 2571
    • 3k Li JM. Wang YH. Yu Y. Wu RB. Weng J. Lu G. ACS Catal. 2017; 7: 2661
    • 3l Ghosh T. Maity P. Ranu BC. Org. Lett. 2018; 20, 1011
    • 3m Mondal S. Hajra A. Org. Biomol. Chem. 2018; 16: 2846
    • 4a Liang H. Jiang K. Ding W. Yuan Y. Shuai L. Chen Y. Wei Y. Chem. Commun. 2015; 51: 16928
    • 4b Xu J. Zhu X. Zhou G. Ying B. Ye P. Su L. Shen C. Zhang P. Org. Biomol. Chem. 2016; 14: 3016
    • 4c Cong X. Zeng X. Org. Lett. 2014; 16: 3716
    • 4d Liu X. Wu Z. Luo X. He Y. Zhou X. Fan Y. Huang G. RSC Adv. 2016; 6: 71485 
  • 5 Koser GF. Relenyi AG. Kalos AN. Rebrovic L. Wettach RH. J. Org. Chem. 1982; 47: 2487
  • 6 Shen C. Yang M. Xu J. Chen C. Zheng K. Shen J. Zhang P. RSC Adv. 2017; 7: 49436
    • 7a Reddy BV. S. Reddy CR. Reddy MR. Yarlagadda S. Sridhar B. Org. Lett. 2015; 17: 3730
    • 7b Reddy CR. Yarlagadda S. Ramesh B. Reddy MR. Sridhar B. Reddy BV. S. Eur. J. Org. Chem. 2017; 2332
    • 8a Hao X. Chen L. Ren B. Li L. Yang X. Gong J. Niu J. Song M. Org. Lett. 2014; 16: 1104
    • 8b Yang Y. Shi L. Zhou Y. Li H. Zhu W. Zhu H. Bioorg. Med. Chem. 2010; 20: 6653
    • 9a Yusubov MS. Wirth T. Org. Lett. 2005; 7: 519
    • 9b Nabana T. Togo H. J. Org. Chem. 2002; 67: 4362
    • 9c Abe S. Sakuratani K. Togo H. J. Org. Chem. 2001; 66: 6174
    • 9d Tuncay A. Dustman JA. Fisher G. Tuncay CI. Tetrahedron Lett. 1992; 33: 7647
  • 10 CCDC 1553346 contains supplementary crystallographic data for the structure 3a. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/getstructures.
    • 11a Basdevant B. Legault CY. Org. Lett. 2015; 17: 4918
    • 11b Carreras V. Sandtorv AH. Stuart DR. J. Org. Chem. 2017; 82: 1279

Zoom Image
Scheme 1 Preparation of Koser’s reagent
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Scheme 2 Oxytosylation of N-(quinolin-8-yl)benzamide (1a)
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Scheme 3 Scope of the reaction. Yield refers to pure products after chromatography.
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Figure 1 ORTEP diagram of 3a
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Scheme 4 Deferential deprotection of amide and tosyl groups
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Scheme 5 A plausible reaction path way