Synfacts 2019; 15(05): 0491
DOI: 10.1055/s-0037-1612481
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Harp on HaRP

Timothy M. Swager
Samuel I. Etkind
Fu L, Xu M, Yu J, Gutekunst WR. * Georgia Institute of Technology, Atlanta, USA
Halide-Rebound Polymerization of Twisted Amides.

J. Am. Chem. Soc. 2019;
141: 2906-2910
Further Information

Publication History

Publication Date:
15 April 2019 (online)



The development of new methods for chain-growth polymerization enables the investigation of novel monomer and polymer architectures with precise control over molecular weight. In this study, Gutekunst et al. develop the Halide-Rebound Polymerization (HaRP), which takes advantage of the increased nucleophilicity of twisted amide 1.



By using an alkyl iodide as an initiator, the resulting chain end is neither air- and moisture-sensitive. This enables the facile synthesis of block co-polymers, as well as quantitative end-group functionalization. Polymer structure was confirmed by both model studies and MALDI-ToF analysis.