We read with great interest the study by Priano titled “Early efficacy of intra-articular
HYADD® 4 (Hymovis®) injections for symptomatic knee osteoarthritis.”[1] The author would like to explore the efficacy of intra-articular HYADD 4 (Hymovis)
injections for symptomatic knee osteoarthritis. Results from this study are very interesting
and promising from a clinical aspect; however, we believe that studying patient's
clinical status with visual analog scale and Western Ontario and McMaster Universities
Arthritis Index scale should be supported by biomechanical information. From this
point of view, to have more data that could influence the clinical practice, it is
important to note the possible action that intra-articular injections of different
kinds of hyaluronic acid could have on walking biomechanics using an objective measurement
tool as gait analysis. In our opinion, the work by Priano[1] is promising because it investigates the efficacy of a new formulation of hyaluronic
acid. Nowadays, many hyaluronic acid formulations are approved for clinical use in
Europe and the United States. Furthermore, hyaluronic acid injections' efficacy has
been demonstrated also in hip osteoarthritis.[2] However, even if these formulations differ in their chemical–physical properties,
joint space half-life, rheological properties, and clinical efficacy, there are few
studies that investigate hyaluronic acid's possible action from a biomechanical point
of view.[3]
[4] From this point of view, we believe that osteoarthritis management and rehabilitation
should be prescribed after an objective analysis of functional walking alterations
using gait analysis instrumentations. The use of gait analysis should be desirable
during diagnosis and follow-up. In fact, it is capable to identify different walking
patterns in patient with osteoarthritis of the lower limbs, whereas the radiology
can evaluate the status of the joint's structures. Moreover, gait analysis can find
the exact altered phase of the walking cycle, guaranteeing a precise prescription
of a rehabilitation program, giving the clinician data about spatial–temporal parameters,
kinematic and kinetic alterations, and about the surface electrical muscle activity
using surface electromyography. In conclusion, gait analysis is easily applicable
to most of the patients, without side effects. Hence, this instrumentation is suitable
for follow-up evaluations and permits to assess any variations of walking biomechanics
over time.
As an example, we would like to present a case of a patient (female, 42 years old)
affected by knee osteoarthritis (II grade—Kellgren and Lawrence classification), treated
with two intra-articular injection of mobile reticulum hyaluronic acid, evaluated
with gait analysis before treatment and 6 months after the treatment. In our patients
is evident the improvement of the flexion–extension kinematic as a consequence of
the treatment performed, in particular, we would like to underline the amelioration
of the first flexion peak at the loading response phase of the walking cycle ([Fig. 1]). Finally, we would like to underline how gait analysis could represent very important
outcome measurement to determinate the efficacy of intra-articular injection therapy
to treat knee osteoarthritis.
Fig. 1 Knee flexion–extension kinematic.
