Introduction:
The incidence of HPV (human papillomavirus) infection of different genotypes is associated
with cancer of various organs. Aim of this study was to prove and compare HPV genotypes
in samples among different sites within the female anogenital tract and the oropharynx
from patients consulting dysplasia clinic.
Methods:
In an ongoing study starting in September 2017 to date we enrolled 178 patients consulting
the dysplasia clinic. The DNA of physician-collected samples from cervix, vagina,
vulva, anus and oropharynx was isolated and HPV genotyping was performed by the Euroarray
HPV.
Results:
Positivity for high risk- (HR-) HPV was verified for 55.69% in anal, 53.37% in vaginal,
53.18% in vulvar and for 50.89% in cervical samples. Low HR-HPV rate was detected
in oropharyngeal samples (10.80%).
HPV16 had the highest incidence in all sites (cervix: 34.88%, vagina: 47.37%, vulva:
45.65%, anus: 47.31, oropharynx: 68.42). Besides HPV16 most frequently found genotypes
were 31, 26, 18, 39, 53 in cervical, 31, 53, 51 in vaginal, 53, 31, 51 in vulvar,
53, 31, 51 in anal, and 53, 51, 39 in oropharyngeal samples.
Statistical analyses of the preference of a special HPV genotype for the investigated
areas and the concordance of HPV genotypes between those still owe.
Conclusion:
Unexpectedly, we found the highest percentage of the HR-HPV as well as the LR-HPV
in the anal samples though the amounts are nearly similar in all anogenital areas.
Besides HPV16 we found discriminative preferences of HPV genotypes for various organs.
