Introduction
Patients suffering from infective aortic valve endocarditis (AVE) remain a diagnostic
and therapeutic challenge. Despite considerable improvements in laboratory testing
and imaging tools used for the early diagnosis, and irrespective of further development
of antibiotic agents with a broader spectrum and greater potency, the early, mid-
and long-term outcome of patients affected by AVE is yet limited.
Surgical therapy aiming the removal of all infected tissue is often the only curative
option. To standardize and to improve clinical practice, specific recommendations
have been released by international scientific societies, including guidelines for
the diagnosis and management of infective endocarditis.[1 ]
[2 ]
[3 ] In 2008, a paradigm change was implied by the guidelines, restricting the use of
antibiotic endocarditis prophylaxis to high-risk patients undergoing invasive procedures
that are associated with a high risk of endocarditis.[4 ]
[5 ] Since then controversies remain on the efficacy and appropriateness of the anti-infective
therapy regimen recommended by the guidelines, and the updated 2015 guidelines have
essentially maintained the principles of the preceding version.[2 ]
[5 ] Among the community for heart medicine, concerns have arisen to whether the current
guidelines may have led to a change in the pattern of infective endocarditis (IE)
as seen in the daily practice. Moreover, considering the aforementioned debate, the
adherence to the guidelines has become a matter of concern.
In 2015, the Working Group on Aortic Valve Surgery has performed a nationwide survey
involving German cardiac surgical institutions to elucidate penetration and adherence
of the current practice for treatment of AVE. This survey was intended to elucidate
regional differences in the incidence and pattern of AVE.
Methods
In 2015, all German institutions performing cardiac surgical procedures were contacted
on behalf of the Working Group on Aortic Valve Surgery of the German Society for Thoracic
and Cardiovascular Surgery (DGTHG, Deutsche Gesellschaft für Thorax-, Herz-und Gefäßchirurgie,
www.dgthg.de ) and asked to participate in a nationwide survey. While designing the questionnaire
and preparing the administrative part of the survey, necessary diligence was given
to the principle of anonymous participation. A web-based questionnaire consisting
of 41 items was designed by the members of the Working Group for Aortic Valve Surgery
to allow for online completion (see [Supplementary Data ] [online only] file for complete questionnaire in its original form). The various
contents were presented and discussed in preceding meetings involving all members
of the working group as well as selected members of the society. The first call for
participation was sent during the second half of the year 2015. After initiating one
memorization, the survey was closed in October 2015, providing the response of 64
centers. All responses were collected and included into a central database allowing
for statistical analysis of the entire data. In a further approach, the results were
regionally categorized to evaluate local differences in Germany, according to the
following definition of regions:
Northeast: Mecklenburg-West Pomerania, Berlin, Brandenburg;
Northwest: Schleswig-Holstein, Hamburg, Bremen, Lower Saxony;
Central East: Saxony, Saxony-Anhalt, Thuringia;
Central West: North Rhine-Westphalia, Hessen, Saarland, Rhineland-Palatinate;
South: Bavaria, Baden-Wuerttemberg.
After analyzing the results, a summary of the survey results was presented at the
45th annual meeting of the German Society for Thoracic and Cardiovascular Surgery
in Leipzig 2016.
Results
Characteristics of the participating Centers
A total of 64 (79%) out of 81 departments participated in the survey with centers
located in the Northeastern (n = 5), Northwestern (n = 11), Central Eastern (n = 6), Central Western (n = 23), and Southern states (n = 19) ([Fig. 1 ]). An almost equal distribution between university hospitals (n = 34) and non-university hospitals (n = 30) was achieved, respectively. Most of the participating institutions perform
an annual load of 1,000 to 1,500 major cardiac operations (43.8%), irrespective of
the use of extracorporeal circulation and excluding cardiac rhythm device operations.
The remaining departments are evenly distributed to the group of centers performing
over 15,00 or <1,000 major procedures (28.1% in each group). Thirty-two departments
announced an annual volume of 200 to 400 operations on patients with acquired aortic
valve diseases (including transcatheter aortic valve implantation [TAVI], but excluding
pediatric patients with congenital heart disease), while eight departments had <200
aortic valve procedures performed per year, and 24 large-volume departments reported
more than 400 aortic valve operations. Concerning specific operative techniques, it
can be asserted that aortic valve replacements (AVR) using biological or mechanical
prostheses were performed by all survey participants. Similarly, the majority of participating
departments perform procedures involving aortic root replacement (95.3%), TAVI (98.4%),
aortic valve sparing or reimplantation techniques (described by Yacoub or David; 96.9%),
or isolated reconstruction of the aortic valve leaflets (85.9%). In contrast, only
30% of all participating departments use a pulmonary autograft for AVR (Ross procedures).
Fig. 1 Regional distribution of cardiac surgical departments participating in the survey.
B, Berlin; BB, Brandenburg; BW, Baden-Württemberg; BY, Bayern; H, Hessen; HB, Bremen;
HH, Hamburg; MV, Mecklenburg-Vorpommern; NS, Niedersachsen; NW, Nordrhein-Westfalen;
RP, Rheinland-Pfalz; S, Sachsen; SA, Sachsen-Anhalt; SH, Schleswig-Holstein; SL, Saarland;
Th, Thüringen.
In the majority of the institutions, an annual volume of 10 to 20 (34.5%) operations
or >20 (51.7%) operations for infective AVE was performed, while the total numbers
of operations for prosthetic AVE was reported to be lower (5–10 operations in 40%
and >10 operations in 37.9%). More complex procedures involving AVR due to AVE as
a concomitant procedure were less frequent (only 25 departments reported an annual
case load >10).
Perioperative Practice Related to Endocarditis Prevention and Follow-Up
Among all participating departments, only 51 (80%) enforce a dental work-up prior
to elective operations on the aortic valve as a routine standard procedure. Perioperative
antibiotic administration (endocarditis prophylaxis) is achieved by either first-generation
cephalosporin (37.6%) or second-generation cephalosporin (60.9%), while in one institution,
a combination of a second-generation cephalosporin and an aminoglycoside is favored.
The respective antibiotics are most commonly administered 30 minutes prior to the
estimated skin incision (67%). A repeated administration after a certain duration
of the operation is practiced by more than half of the participating centers (53.1%).
A smaller fraction of the participants prefer an administration at the time of skin
incision (14%) or at a time earlier than 30 minutes prior to skin incision (11%).
In regards to discharge recommendations after an operation for infective endocarditis,
a heterogeneous picture is revealed. We asked, whether immediate reconsultation is
recommended to the patients and their referring physicians in case of fever, elevated
inflammatory parameters, or abnormal echocardiographic findings. The latter recommendation
is issued by 65.6% of the participating departments.
Trends in the Intraoperative Management
The choice of the optimal prosthesis for replacement of the infected aortic valve
has been the focus of scientific investigation and a matter of long standing debate
in the surgical community. Based on the results of this survey, stented xenografts
were the prosthesis of choice for AVR in the instance of uncomplicated native AVE,
i.e., without destruction of concomitant structures, as preferred by 65.5%. In 22.4%,
neither heart valve prosthesis types is systematically favored, and in a minority
of 8.6%, a stentless xenograft is reported as the prosthesis of choice ([Fig. 2 ]).
Fig. 2 Preferred prosthesis type for aortic valve replacement in the setting of infective
endocarditis. Pie chart demonstrates the proportion of centers indicating respective
prosthesis types as the overall preferred substitute for the infected aortic valve
(n = 58).
In a more specific approach, the questionnaire asked for the cut-off age used to decide
for a mechanical versus a biological heart valve prosthesis in infective AVE ([Fig. 3 ]). In seven departments, a mechanical heart valve prosthesis was not used in patients
undergoing AVR for AVE, while in three departments, in all patients, a mechanical
aortic valve prosthesis was chosen. In the remaining group of survey participants,
a more liberal use of biological aortic valve prostheses becomes obvious, with almost
one third choosing a biological prosthesis in patients at least 50 years old, and
>95% preferring a biological prosthesis for patients above 60 years of age. Although
this survey had the specific background of infective endocarditis, its finding confirms
a general trend to favor the use of biologic aortic valve prosthesis.
Fig. 3 Age cut-off for choice of biological prosthesis in the setting of IE. Proportion
of departments that preferably use biological prostheses in the respective age cohorts
of IE patients is indicated. IE, infective endocarditis; Yrs, years.
To elucidate the predominant surgical practice for the treatment of aortic root abscess
formation, several common techniques were offered to choose from. In the majority
of all responses, a technique using a pericardial patch to cover the abscess cavity
was favored, whereas the implantation of a biological conduit (18.9%), a stentless
xenograft (17.2%) or a homograft (8.6%) was less favorable, respectively. Finally
a pericardial patch technique (5.1%), draining the abscess into the pericardial cavity,
or the implantation of a mechanical conduit (1.7%) was least favored, respectively.
Perioperative Diagnosis and Timing of Surgery
Due to the significance of AVE-associated splenic abscesses, the preferred point of
time for a splenectomy was explored. A vast majority of 84.5% indicated a staged procedure
with splenectomy following valvular cardiac surgery as the standard protocol, whereas
in only 15.5% splenectomy is performed prior to cardiac surgical AVR. In no case,
a simultaneous operation was announced as the standard procedure, addressing the infected
aortic valve and the splenic abscess.
According to the survey, a wide range of diagnostic steps are routinely performed
prior to cardiac surgery for AVE. None of the offered multiple answer options, regarding
the diagnostic steps were, chosen by any of the participants. The most frequently
applied diagnostic examinations were transthoracic (98.1%) and transesophageal echocardiography
(71.7%), cardiac catheterization for coronary angiography (58.5%; in 34%, only in
the absence of valvular vegetation), cerebral (60.4%), thoracic (24.5%) and abdominal
computed tomography (CT) (37.7%), and abdominal ultrasonic examination (30.2%). Magnetic
resonance imaging (MRI) was less frequently applied (cerebral MRI in 5.7%; thoracic
or abdominal MRI in 1.9%) ([Fig. 4 ]). A total of 79.3% of the departments used the modified Duke criteria to confirm
the diagnosis of IE, and the same number of participants considered the presence of
a free mobile valvular vegetation, and its dimensions as a crucial factor for the
indication for surgery. More specifically, vegetation dimensions greater than 10 mm
were well accepted as an indication for surgery (66%) and also lower dimensions in
case of mobile vegetations (18.9% for <5 mm and 30.2% for 5–10 mm).
Fig. 4 Diagnostic tools routinely used for the planning of surgery for IE. Proportion of
departments utilizing specific diagnostic methods as a routine tool in the perioperative
treatment of patients with IE. The respective methods are in the order of their routine
popularity as a routine step for patients undergoing cardiac surgery for IE. aCT scan,
abdominal computer tomography scanning; aMRI, abdominal magnetic resonance imaging;
aSon; abdominal sonography; cCT scan, cranial computer tomography scanning; cMRI,
cranial magnetic resonance imaging; cor angio, coronary angiography; cor angio wo
veg; coronary angiography performed only under the condition of absent vegetation;
IE, infective endocarditis; TEE, transesophageal echocardiography; thCT scan, thoracic
computer tomography scanning; thMRI, thoracic magnetic resonance imaging; TTE, transthoracic
echocardiography.
Regarding the timing of cardiac surgery in the case of prior cerebral embolism, a
wide range of strategies became evident ([Fig. 5 ]). Answers for the optimal time interval varied between 24 hours and up to 6 weeks
after the embolism, also included the option not to operate on these patients and
the strategy of timing surgery irrespective to the event of cerebral embolism. The
highest approval was noted for cardiac surgery under extracorporeal circulation (ECC)
conditions irrespective of the time of cerebral embolism (36%) or within the first
48 hours (30.2%). In 24.5% of the participating departments, a preceding cerebral
embolism with associated intracerebral bleeding was regarded as a contraindication
for cardiac surgery, whereas 11.3% stated to perform surgery irrespective of the same
finding.
Fig. 5 Preferred timing of surgery for IE with cerebral embolization. Number of departments
preferring cardiac operation for embolizing IE within specific time windows following
a cerebral embolization. The two columns at the left indicate the number of departments
that in general deny operative therapy in patients with cerebral embolization and
intracranial bleeding (No OP w ICB) or those departments performing cardiac operation
in the latter setting without delay (any time w ICB). h, hours; ICB, intracranial
bleeding; IE, infective endocarditis; wks, weeks.
Diagnosis and Treatment of the Infectious Focus
To gain an insight into the diagnostic testing and antibiotic treatment practice,
the questionnaire asked for the rate of successful detection of the germs causing
AVE. In slightly more than half of all departments, a microbiological germ was identified
as the cause of AVE in >50% of the patients in the year 2014, and in 32.1% of the
participating departments, this rate exceeded 75% ([Fig. 6 ]). The most frequently used probes allowing the detection of AVE were blood cultures
(98%), intraoperative swabs (92%), microbiological cultures (94%), and histology of
valvular tissue material (90%). Predominantly monoinfections were observed, >75% of
all patients in 54.7% of the participating sites and in 50 to 75% of all patients
in 22.6% of all departments. Among the detected microorganism, fungal species was
a rare entity with a proportion of <1% in 66% of all participating departments. The
most commonly reported species were Staphylococcus aureus (92.5%), Staphylococcus epidermidis (77.4%), unspecified Staphylococcus (83%), unspecified Streptococcus (79.3%), Escherichia coli (54.7%), and Escherichia faecalis (45.3%). Methicillin-resistant S. aureus (MRSA) and vancomycin resistant E. coli (VRE) were reported by 37.7% and 9.4% as the cause for IE in 2014, respectively ([Fig. 7 ]). There was a great variance regarding the frequency of cases in which the results
of preoperative blood samples were subsequently confirmed by further microbiological
evaluation of intraoperative samples (aortic valve tissue and other tissue samples).
One fourth of all departments achieved such confirmation in >75%, while about one-fourth
of the participants found such a confirmation in <50% of their patients, and 28% of
the participants reported to have no data on this issue.
Fig. 6 Successful diagnostic confirmation of underlying organisms. The rate of successful
diagnosis of the organism causing IE differs remarkably across the departments participating
in the survey. In almost half of all departments, a successful diagnosis of the causative
organism was performed in >50% of all their IE patients, whereas 32% of all departments
indicated a success rate above 75% (purple). IE, infective endocarditis.
Fig. 7 Frequency of centers experience specific germs causing infective endocarditis of
the aortic valve. Staphylococcus aureus and Streptococcus epidermidis were the most frequently reported subspecies and Staphylococci and Streptococci the
most common bacterial families.
A recurrent AVE (AVE in a patient with previous AVE in personal medical history) is
less frequent and affects <25% of the total number of AVE patients at the majority
of the participating departments. However, we were not able to elucidate whether the
recurrent AVE was predominantly caused by the same species as in the index AVE (58.5%
reported to have no data on this issue).
Besides the surgical therapy, antibiotic regimen remains a cornerstone in the treatment
of AVE. According to our survey a calculated antibiotic therapy was most commonly
performed with a combination of three antibiotic agents (54%), while a smaller group
applies a dual combination (16%). Thirty percent of all responders indicated to treat
their patients “according to the current guidelines,” an option provided among the
possible answers to this question. Following this topic, the specific antibiotics
used for a calculated therapy were explored in a multiple choice manner. Gentamycin
(60%), vancomycin (56%), and rifampicin (54%) were the most frequently applied agents,
while other antibiotics were selected by 30% or less of the participants. However,
as for the previous question, the option “according to the current guideline” was
frequently chosen (54%). For recommending the duration of an antibiotic treatment,
the day of operation was generally regarded as the relevant point in time marking
the beginning of the time window (in 64% of participating departments), while in a
smaller part of the participants, the preoperative begin was regarded as more relevant
(16%). In case of native AVE caused by S. aureus , the majority of the departments prefer an intravenous (IV) antibiotic treatment
for 6 weeks following surgery, while in a minority of departments, IV treatment routinely
exceeded 6 weeks (8%) or remained shorter than 6 weeks (4 weeks in 24% and 2 weeks
in 6%). However, a trend toward longer IV antibiotic treatment was observed for prosthetic
endocarditis with the same microorganism (≥6 weeks in 86% of all departments). Finally,
we asked for the standard treatment duration for Candida caused AVE. The most frequently applied duration of postoperative IV treatment was
6 weeks (44%), while 42% preferred a prolonged treatment of >6 weeks. Similar to the
trend observed for bacterial prosthetic valve AVE, the majority of 52% of departments
prolonged IV treatment for >6 weeks in the event of prosthetic valve endocarditis.
Aortic Valve Endocarditis after Prosthetic Aortic Valve Replacement
In the majority of the departments (62.3%), a prosthetic heart valve endocarditis
after AVR was observed >1 year after the initial operation. Interestingly, an early
prosthetic AVE within the first year was more frequently observed when AVR was performed
due to AVE: 52.8% of all participants described the first year after the index operation
being the typical time frame for the occurrence of a recurrent AVE.
Discussion
The present work summarizes the results of a nationwide survey among cardiac surgical
departments in Germany to determine the contemporary findings and practice in the
surgical management of infective endocarditis. A total of 64 departments participated
in the survey with an almost equal distribution between university hospital departments
and departments outside of university hospitals. Considering the completeness of the
data entry, the results of the current survey compare well with a previous nationwide
survey initiated by the DGTHG and focusing on sternal wound complications after cardiac
surgery.[6 ] Moreover, the collected results from German cardiac surgical departments across
all geographic regions of the country were collected, therefore providing the herein
presented results with a representative character for the German-wide practice today,
particularly when considering the overall landscape of cardiac surgical institutions
in Germany and their annual performance.[7 ]
As a first crucial step in the management of AVE, the diagnostic process as practiced
in the participating departments was explored. While TEE represented the standard
diagnostic tool performed by almost all departments, neither a preoperative coronary
angiography nor a CT scan was regarded as mandatory for all patients undergoing cardiac
surgery for AVE. Indeed, class I recommendation for diagnosis (and surgical management
of AVE) exists for TTE and TEE, whereas according to guidelines, cardiac CT scan is
reasonable (class IIA, level of evidence B) when local complications, e.g., perivalvular
abscess formation, are suspected.[3 ] In contrast, there is a lack of evidence for the benefit of coronary artery screening
for patients undergoing cardiac surgery for AVE, and cardiac surgery without coronary
angiography is a reasonable approach as recommended by the guidelines (class IIa)
and frequently practiced in Germany according to the results of the presented survey.[3 ]
Most interestingly, a large diversity was observed regarding the indication and timing
for cardiac surgery in case of septic embolization. As a matter of fact, large controversy
continues on the optimal management of patients presented with recent stroke due to
AVE-associated cerebral emboli. A recent report from a high-volume German department
for cardiac surgery summarizing the results of 375 patients undergoing cardiac surgery
for left heart IE with preoperative cerebral emboli underlines the severe impact of
this complication.[8 ] Preoperative cerebral, abdominal, and thoracic CT scans were performed on all patients
admitted with IE (a total of 1,571 patients). Based on the large cohort investigated,
the authors demonstrated a similarly impaired outcome for both patients with clinically
apparent cerebral emboli as well as patients with preoperative silent emboli detected
with cranial CT scan or cranial MRI. The rate of postoperative hemiplegia as well
as intracranial bleeding was comparable in both groups, despite the distinct preoperative
clinical presentation of these cohorts. Although prospective data are yet missing,
it appears likely that an intensified preoperative screening for extracardiac complications
of IE may help to determine the specific treatment strategy in each individual patient.
Data from other studies support the aforementioned results. A systematic screening
by CT or MRI imaging has demonstrated cerebral mycotic aneurysms in 32% and abnormal
findings in visceral organs in 34% of the analyzed patients.[9 ]
[10 ] Further reports based on MRI or CT findings estimate the proportion of IE patients
suffering from a high rate of cerebral emboli, reaching up to 80%.[11 ] Although not yet implemented in the current guidelines, a systematic neurological
imaging prior to surgery for IE may improve the outcome and has been propagated by
some authors.[12 ] A second trend was an early operative therapy of IE even in case of silent or ischemic
cerebral embolism. Although this strategy has to be validated by further prospective
studies, this concept is already specified in the European and North American guidelines.[2 ]
[13 ] A delayed operation is only recommended in cases of hemorrhagic stroke.[2 ]
[13 ] The rationale behind this approach is derived from the fact that delayed surgery
is more likely associated with systematic deterioration of the patient with less favorable
overall outcome, while the benefit in terms of reduced risk of perioperative neurological
exacerbation remains questionable.[12 ]
Another aspect of IE treatment as elucidated by the survey has to be further analyzed.
Only half of all survey participants announced a positive finding of the underlying
microorganism, which is significantly lower than rates previously published in Germany
and elsewhere.[8 ] However, as stated by the current European Society of Cardiology (ESC) guidelines,
“positive blood cultures remain the cornerstone of diagnosis.”[2 ] It remains unclear whether the numbers reported by the survey participants reflect
a true diagnostic gap currently present or whether other issues may have led to an
artificially high rate of cases with missing diagnosis of the underlying organism.
Among the remarkable findings of this survey, a strong trend toward the use of xenografts
for aortic valve replacement in the setting of AVE was noted, with a notable proportion
of the departments generally excluding mechanical prosthesis for this indication.
This trend is in line with the general tendency of a more liberal use of biological
valve prostheses for heart valve replacement across Europe and worldwide, although
data on the long-term outcome of young patients receiving biological prostheses is
still inconsistent.[14 ]
The results presented here are limited by the fact that not all of the cardiac surgical
departments participated despite the repeated nationwide call by the DGTHG. Moreover,
technical measures to ensure an anonymous modality of participation may have had an
impact on the quality of data acquisition, e.g., the identity and organizational position
of the person filling out the survey remains unclear. Finally, due to the voluntary
nature of the survey as well as the aforementioned anonymous data supply, no structural
mechanisms controlling the validity of the entered data were available. However, our
results represent the largest data collection focused on the current practice in cardiac
surgery for AVE and provide corner stones for planning and performing consecutive
nationwide studies on AVE.
