HISTOPATHOLOGICAL FEATURES OF POSTCOLONOSCOPY COLORECTAL CANCER

V Sastre Lozano; S Morán Sánchez; J García Solano; P Conesa Zamora; G Ruiz Merino

doi:10.1055/s-0039-1681826

Endoscopy, Table of Contents

Endoscopy 2019; 51(04): S219-S220
DOI: 10.1055/s-0039-1681826

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Friday, April 5, 2019 09:00 – 17:00: Colon and rectum ePosters

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HISTOPATHOLOGICAL FEATURES OF POSTCOLONOSCOPY COLORECTAL CANCER

Authors

V Sastre Lozano

¹Hospital Santa Lucía, Cartagena, Spain
S Morán Sánchez

¹Hospital Santa Lucía, Cartagena, Spain
J García Solano

¹Hospital Santa Lucía, Cartagena, Spain
P Conesa Zamora

¹Hospital Santa Lucía, Cartagena, Spain
G Ruiz Merino

²Biosanitary Research and Innovation Area, Foundation for Health Training and Research, Murcia, Spain

Abstract

Full Text

Aims:

The targets of this study are to describe postcolonoscopy colorectal cancer (PCCRC) histopathological features and to evaluate relevant differences between PCCRC and sporadic colorectal cancer (SCRC) in this topic.

Methods:

A retrospective simple centre study in a Universitary Hospital was carried out. Colorectal cancer (CRC) cases diagnosed for three years period were revised (n = 291). PCCRC cases were identified (n = 17; 6 – 60 months after a negative colonoscopy). Statistically significant differences regarding histological type in both groups were analysed (PCCRC vs. SCRC). To value histopathological differences, PCCRC cases and a SCRC control group were paired (1:1) regarding histological type, tumoral grade, tumour stadium and location. Features related with CRC prognosis were re-examined by an expert pathologist (lymphatic, vascular and perineural invasion, budding tumour mayor than 10, tumoral grown type, peritumoral lymphoid inflammatory infiltration grade, lymphoid Crohn type response and Tumour Intraepithelial lymphocytes. Statistical analysis: Pearson X²test for qualitative variables.

Results:

Serrated adenocarcinoma and High-Microsatellite Instability Carcinoma (MSI-H) were more frequent in PCCRC group tan in SCRC (23.53% and 11.76% versus 14.57% and 2.21% respectively), but differences were not significant. All cases of PCCRC had an inflammatory infiltration (High or Low grade) versus 58.83% in SCRC control group (p = 0.011). Lymphoid Crohn type response was present in 47% of PCCRC cases versus 5.88% of SCRC control group (p = 0.007) (Table 1). There were no statistical differences in the other histopathological features.

Conclusions:

There are few studies in the literature that analyse PCCRC pathological features. There are some references to molecular aspects. Studies about histopathological characteristics described above have not been found. Predominating Inflammatory infiltration and lymphoid Crohn type response are histopathological features observed in PCCRC with significant difference. Further studies are necessary to extrapolate results observed in this study.