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Synfacts 2020; 16(03): 0289
DOI: 10.1055/s-0039-1690348
DOI: 10.1055/s-0039-1690348
Metals in Synthesis
Palladium-Catalyzed Dicarbonylation of 1,3-Dienes for the Synthesis of Adipic Acid Esters
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Februar 2020 (online)
Significance
The authors describe a palladium-catalyzed dicarbonylation of 1,3-dienes using carbon monoxide. Various adipate diesters were produced in good to excellent yield with high selectivity.
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Comment
The authors used kinetic experiments to support the proposed mechanism. Scaling up the reaction to over 200 g with a lower catalyst loading gave the product in excellent yield and selectivity.
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