Monoterpene indole alkaloids (MIAs) constitute a broad class of nitrogen-containing
plant-derived natural products composed of more than 3000 members.[1] This natural product class is found in hundreds of plant species from the Apocynaceae,
Loganiaceae, Rubiaceae, Icacinaceae, Nyssaceae, and Gelsemiaceae plant families. Throughout
the six past decades, the structural intricacies and biological activities of these
molecules have captured the interest of many researchers all over the world.
As part of our continuing interest in MIA chemistry, we recently implemented an in-house
MS/MS database, constituted of a cumulative collection of alkaloids from the global
natural products research community. These endeavors led to the construction of the
largest MS/MS dataset of MIAs to date, that we named: Monoterpene Indole Alkaloids
DataBase (MIADB).[2] Thanks to this database, we developed a streamlined molecular networking dereplication
pipeline directed toward the reinvestigation of previously studied MIA-containing
plants. This pipeline allowed to prioritize the isolation workflow toward new alkaloids
bearing unprecedented carbon skeleton and interesting biological activities. This
presentation is intended to describe the most significant results gleaned from the
reinvestigation of several forgotten plants by this new generation of sophisticated
tools.
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