Introduction Lymphomas represent fourth most commom cancer in peruvian children (10% of all cases).Currently,
different cooperative groups are reducing intensity of chemotherapy and radiotherapy
with intension to improve survival and reduce sequelae. Limited data such as information
on epidemiology and survival are available in peruvian pediatric population .This
study aimed to describe clinical, histological characteristics, risk group distribution
and survival in pediatric Hodgkin lymphoma(HL) patients
Methods Children (≤14 years old) diagnosed with histologically proven HL from 2009 to 2015
were retrospectively analyzed. . The Kaplan-Meier survival curves were used for survival
analysis.
Results 117 patients were enrolled; predominantly male 3:1, mean age of 7.3 years, range
3 to 14 years and 72 % came from outside Lima. Disease time has a mean of 8 months,
B symptoms were present in 45 %, 51.6% has bulky mass, primary site was neck in 47%,
52.8% of the patients were at high risk group. The histopathological diagnosis was
mixed celular type in 52.9% and nodular sclerosis in 19.5% of the patients,64.9% express
latent membrane protein 1 (LMP1) by inmunohistochemestry. We used ABVD chemotherapy
to treat low/intermedate risk and ABVD/COPD for high risk group, 68% has good early
response, 80% of slow early responders receive radiotherapy at mean dose 2600 cGy,
18.8% of patients left therapy, 11.7% relapse. With a median follow-up of 24 months,
the 5-year overall and event-free survival rates were 94.2% and 92.7% respectively
(abandonment is not included). Sex, treatment risk groups, presence of B symptoms,
bulky mass and histology type had no significant effect on overall survival.
Conclusion Advanced disease, bulky mass, B symptoms, EBV expression and mixed celular histology
are main characteristics in peruvian HL. We must to improve education and follow up
to reduce high abandonment rates.
