Download PDF
Synfacts 2020; 16(09): 1115
DOI: 10.1055/s-0040-1705854
Peptide Chemistry

An N-Protecting Group for Solid-Phase Peptide Synthesis in Aqueous Media

Contributor(s):
Hisashi Yamamoto
,
Tomohiro Hattori
Knauer S, *, Koch N, Uth C, Meusinger R, Avrutina O, Kolumar H. * Sulfotools GmbH, Darmstadt and Technische Universität Darmstadt, Germany
Sustainable Peptide Synthesis Enabled by a Transient Protecting Group.

Angew. Chem. Int. Ed. 2020;
59: 12984-12990
CrossrefPubMedGoogle Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Key words

solid-phase synthesis - peptide synthesis - aqueous media - protecting group - fluorescence

Significance

Peptide synthesis in water as the solvent is underdeveloped. The author have developed a solid-phase peptide synthesis (SPPS) in aqueous media by using a new 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) N-protecting group.


#

Comment

The authors developed the Smoc group as an N-protecting group. The Smoc group, which is fluorescent, can be used for SPPS in aqueous media and is easily removed.


#
#

Publication History

Article published online:
18 August 2020

© 2020. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany


   Permissions and Reprints