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Synthesis of (+)-Haperforin G
Key words(+)-haperforin G - limonoids - tetranortriterpenoids - ring-closing metathesis - Pauson–Khand reaction - light-mediated radical coupling - aldol addition
Chen, Yang, and co-workers report the first total synthesis of (+)-haperforin G, a structurally complex member of the limonoid family of tetranortriterpenoid natural products. Their synthesis features an efficient radical coupling of two fragments.
Intermediate G is accessed from A in nine steps and transformed to H via a Pauson–Khand reaction. Further six steps give rise to I, which is then joined with M via a light-mediated radical-based coupling to obtain O.
20 January 2021 (online)
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