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Planta Med 2017; 83(07): 631-635
DOI: 10.1055/s-0042-120545
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory Activity

Miao Dong   *
1   Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, China
2   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Dan Liu   *
2   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Yan-Hong Li
2   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Xuan-Qin Chen
2   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
,
Kai Luo
3   Paris School of Business, Management and Strategy Department, Paris, France
,
Yong-Min Zhang
4   Université Pierre et Marie Curie-Paris 6, Institute Parisien de Chimie Moléculaire, Paris, France
,
Rong-Tao Li
2   Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
› Author Affiliations
Further Information

Publication History

received 28 August 2016
revised 28 October 2016

accepted 04 November 2016

Publication Date:
16 November 2016 (online)

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Erratum: Naphthoquinones from Onosma paniculatum with Potential Anti-inflammatory ActivityPlanta Med 2017; 83(07): E2-E2
DOI: 10.1055/s-0043-100122

Abstract

Four new naphthoquinones (1–4), including a dimeric one, shikometabolin G (1), together with six known ones (6–10), were isolated from the methanol extract of Onosma paniculatum. Their structures were established based on the analysis of NMR and MS spectroscopic data. All of the compounds were evaluated for inhibitory effects on NO production in murine macrophage RAW 264.7 cells. Compounds 2, 3, 5, 6, 7, 8, and 10 displayed good activity on the inhibition of NO production (IC50 = 0.4–16.5 µM), suggesting the potential property of anti-inflammation.

Key words

Boraginaceae - Onosma paniculatum - naphthoquinone - shikometabolins - anti-inflammation

* These two authors contributed equally to this work.


Supporting Information

HR-ESI-MS and NMR spectra of shikometabolin G (1) and naphthofuranin A–C (2–4) are available as Supporting Information.

 

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