Aims Assessment of the role of antibiotics in endoscopic transmural drainage of post-inflammatory
pancreatic and peripancreatic fluid collections (PPPFCs).
Methods Randomized trial covering study group of 62 patients treated endoscopically due to
PPPFCs in 2020 in our medical center. The first group consisted of patients who were
receiving empirical intravenous antibiotic therapy during endotherapy. The second
group consisted of patients without antibiotic therapy during endoscopic drainage
of PPPFCs.
Results 31 patients were included into the first group (walled-off pancreatic necrosis [WOPN]-
51.6%, pseudocyst-48.4%) and 31 patients into the second group (WOPN-58.1%, pseudocyst-
41.9%) (p=NS). Infection of PPPFCs content was stated in 16/31 (51.6%) patients from
the first group and in 14/31 (45.2%) patients from the second group (p=NS). Average
time of active drainage in the first group was 13.0 (6-21) days and in the second
group – 14.0 (7-25) days (p=NS). Total number endoscopic procedures on one patients
was on average 3.3 (2-5) in the first group and 3.4 (2-7) in the second group (p=NS).
Clinical success of endotherapy of PPPFCs was stated in 29/31 (93.5%) patients from
the first group and in 30/31 (96.8%) patients from the second group (p=NS). Complications
of endotherapy in the first group were stated in 8/31 (25.8%) patients and in 10/31
(32.3%) patients in the second group (p=NS). Long-term success was stated in 26/31
(83.9%) patients in the first group and in 24/31 (77.4%) patients in the second group
(p=NS).
Conclusions No antibiotic therapy is required in cases of efficient endoscopic transmural drainage
of sterile and infected PPPFCs.
