Saha AK,
Schultz P,
Rapoport H.
*
University of California, Berkeley, USA
1,1'-Carbonylbis(3-methylimidazolium) Triflate: An Efficient Reagent for Aminoacylations.
J. Am. Chem. Soc. 1989;
111: 4856-4859
DOI:
10.1021/ja00195a043
Key words
CDI - 1,1'-carbonylbis(3-methylimidazolium) triflate - amino acid esters - peptide
synthesis
Significance
The development of new coupling reagents for the synthesis of amino esters and peptides
is highly demanded in organic synthesis. In 1989, the authors invented 1,1'-carbonylbis-(3-methylimidazolium)
triflate as an efficient reagent for the synthesis of amino esters and peptides.
Comment
A series of amino esters and peptides were synthesized with the aid of 1,1'-carbonylbis(3-methylimidazolium)
triflate as the coupling agent. The reaction protocol is simple and proceeds without
loss of optical purity.
