Giant pedunculated Brunner’s gland adenoma – transpyloric endoscopic resection

Abstract Text We present a case that illustrates the successful endoscopic resection of a giant Brunner’s gland adenoma. A 76-year-old female patient presented with iron deficiency anemia. The upper GI endoscopy revealed a giant pedunculated polyp arising from the transition between the first and the second duodenal portions, with biopsies revealing Brunner’s gland hyperplasia. We removed the giant polypoid lesion by mobilizing it to the gastric antrum to facilitate the endoscopic resection. The resection specimen measured 9 cm of maximum length. The histology confirmed the diagnosis of a Brunner’s gland adenoma, without dysplasia.