Abstract Text A 7-year-old female patient was referred to our department for double balloon enteroscopy
(DBE). At age 5 she was diagnosed with Crohn’s disease based on failure to thrive,
iron-deficiency anemia and capsule endoscopy showing small bowel ulcers. Steroids
did not result in clinical improvement. She had recurrent episodes of otitis media.
After being non-responsive to azathipoprine she was sent for DBE. We found nodular
lymphoid hyperplasia and aphtous ulcers in the ileum. Histology showed lack of plasma
cells, NLH and increased intraepithelial lymphocytes. Serum immunoglobulins were low,
confirming common variable immunodeficiency. The patient responded to the therapy
with intravenous immunoglobulins.
