Kamiński ZJ.
Technical University of Łódź, Poland
2-Chloro-4,6-Dimethoxy-1,3,5-Triazine: A New Coupling Reagent for Peptide Synthesis.
Synthesis 1987; 917-920
DOI:
10.1055/s-1987-28122
Key words
2-chloro-4,6-dimethoxy-1,3,5-triazine - coupling reagents - peptide synthesis
Significance
The development of efficient, racemization-free methods for peptide synthesis is highly
demanded in the peptide industry. In 1987, Kamiński invented 2-chloro-4,6-dimethoxy-1,3,5-triazine
as an efficient coupling reagent for peptide synthesis.
Comment
A series of di-, tri-, and pentapeptides were synthesized by coupling for N-protected
amino acids or corresponding peptides with amino acid ester or peptides. This protocol
uses mild conditions and proceeds without concomitant racemization.
